Gene Information gene info

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GENE：DTX4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DTX4
FullNmae deltex E3 ubiquitin ligase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29151
EnsembleID ENSG00000110042
Uniprot Q9Y2E6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DTX4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DTX4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DTX4 GO:0004842,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0007219,GO:0008270,GO:0010498,GO:0016567,GO:0016567,GO:0032479,GO:0043161,GO:0045824,GO:0061630,GO:0061630

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DTX4 hsa:23220 path:hsa04330 Notch signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DTX4 NOTCH3 10531053 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR DTX4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DTX4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DTX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DTX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DTX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DTX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DTX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DTX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DTX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DTX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 DTX4 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000427B68 DTX4 20371350 21572407 23313552 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB DTX4 20371350 21572407 23313552 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000028FD1A DTX4 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000000C73C DTX4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 DTX4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 DTX4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F DTX4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A DTX4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B DTX4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC DTX4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB DTX4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 DTX4 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HSP90AB1 DTX4 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
NOTCH1 DTX4 25348397 N/A physical interaction ComPPI
HSP90AA1 DTX4 25348397 N/A physical interaction ComPPI
TBK1 DTX4 25348397 N/A physical interaction ComPPI
NLRP4 DTX4 25348397 N/A physical interaction ComPPI
HSP90AA2P DTX4 25348397 N/A physical interaction ComPPI
DTX4 EPRS1 24234451 30021884 physical association cross-linking study IntAct
DTX4 TBK1 10531053 27898060 inhibition N/A OmniPath

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