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GENE：CDC25C

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDC25C
FullNmae cell division cycle 25C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1727
EnsembleID ENSG00000158402
Uniprot P30307

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDC25C parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDC25C mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDC25C autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CDC25C GO:0000079,GO:0000086,GO:0000086,GO:0000086,GO:0004721,GO:0004725,GO:0004725,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005758,GO:0005829,GO:0007088,GO:0007283,GO:0008283,GO:0010971,GO:0019901,GO:0048471,GO:0050699,GO:0051301,GO:0110032

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDC25C hsa:995 path:hsa04110 Cell cycle - Homo sapiens (human)
CDC25C hsa:995 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
CDC25C hsa:995 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
CDC25C hsa:995 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
CDC25C hsa:995 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIN1 CDC25C 10037602 23180781 9499405 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 CDC25C 11799066 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 CDC25C 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CDC25C 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC CDC25C 12747840 22446629 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C CDC25C 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 CDC25C 18971253 19861536 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 CDC25C 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP63 CDC25C 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CDC25C 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CDC25C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CDC25C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CDC25C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CDC25C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
OTX2 CDC25C 21047732 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CDC25C N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 CDC25C 19461653 25416803 mrna cleavage,inhibition array technology TarBase
URS0000170CF4 CDC25C 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003E1A9 CDC25C 23596351 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001E0AEA CDC25C 25416803 26805039 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 CDC25C 22135298 phosphorylation N/A PhosphoSite
MAPKAPK2 CDC25C 22135298 phosphorylation N/A PhosphoSite
CHEK1 CDC25C 22135298 phosphorylation N/A PhosphoSite
CDK1 CDC25C 22135298 phosphorylation N/A PhosphoSite
CHEK2 CDC25C 22135298 phosphorylation N/A PhosphoSite
CDK2 CDC25C 22135298 phosphorylation N/A PhosphoSite
PLK1 CDC25C 22135298 phosphorylation N/A PhosphoSite
RPS6KA1 CDC25C 22135298 phosphorylation N/A PhosphoSite
MAPK9 CDC25C 22135298 phosphorylation N/A PhosphoSite
MAPK8 CDC25C 22135298 phosphorylation N/A PhosphoSite
MARK3 CDC25C 22135298 phosphorylation N/A PhosphoSite
PLK3 CDC25C 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIN1 CDC25C 10037602 14525934 25348397 9482729 9499405 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK9 CDC25C 25348397 N/A physical interaction ComPPI
ROR2 CDC25C 25348397 N/A physical interaction ComPPI
HSPBP1 CDC25C 25348397 N/A physical interaction ComPPI
PCNA CDC25C 11559705 11896603 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
YWHAG CDC25C 24234451 25348397 28330616 association pull down,physical interaction ComPPI,IntAct
CBY1 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MAPK1 CDC25C 25348397 N/A physical interaction ComPPI
HRAS CDC25C 14525934 25348397 9154803 N/A two hybrid,two hybrid ComPPI,HPRD
ERBB4 CDC25C 25348397 N/A physical interaction ComPPI
TIAM1 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
LCK CDC25C 11389730 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SHC1 CDC25C 25348397 N/A physical interaction ComPPI
MAPK3 CDC25C 25348397 N/A physical interaction ComPPI
MAPK14 CDC25C 10557092 11333986 11551930 14525934 25348397 9278512 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CTBP2 CDC25C 25348397 N/A physical interaction ComPPI
HDAC4 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SUFU CDC25C 25348397 N/A physical interaction ComPPI
RTKN CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GIGYF1 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PKN1 CDC25C 14525934 15791647 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
YWHAB CDC25C 12937170 14525934 19470455 24234451 24255178 25348397 28330616 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
YWHAZ CDC25C 10864927 14525934 15161933 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RPS27A CDC25C 25348397 N/A physical interaction ComPPI
HSP90AA1 CDC25C 25348397 N/A physical interaction ComPPI
MAGI1 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ILK CDC25C 25348397 N/A physical interaction ComPPI
STIP1 CDC25C 25348397 N/A physical interaction ComPPI
PLK1 CDC25C 11202906 11897663 12595692 14525934 14532005 16753148 17307877 19597481 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,classical fluorescence spectroscopy,coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PHLDB2 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
STARD13 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
YWHAQ CDC25C 14525934 25348397 9543386 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CSNK2A2 CDC25C 25348397 N/A physical interaction ComPPI
CDK2 CDC25C 25348397 N/A physical interaction ComPPI
CHEK1 CDC25C 10557092 10681541 11333986 11551930 11836499 14525934 16330544 24234451 25348397 9278511 9278512 phosphorylation reaction affinity chromatography technology,experimental interaction detection,physical interaction,protein kinase assay,in vitro ComPPI,HPRD,IntAct
EGFR CDC25C 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
YWHAH CDC25C 10330186 14525934 24234451 25348397 28330616 9278512 association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SFN CDC25C 25348397 N/A physical interaction ComPPI
YWHAE CDC25C 19331823 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
HSPA4 CDC25C 25348397 N/A physical interaction ComPPI
CHEK2 CDC25C 10557092 10744722 11333986 11551930 14525934 25348397 9278512 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SH3PXD2A CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CCNB2 CDC25C 25348397 N/A physical interaction ComPPI
CCNB1 CDC25C 10864927 14525934 1836978 25348397 8402895 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PLK3 CDC25C 10557092 11333986 11551930 14525934 25348397 9278512 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDK5 CDC25C 25348397 N/A physical interaction ComPPI
BRSK1 CDC25C 14525934 15150265 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PTPN13 CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NEDD4 CDC25C 10037602 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDC37 CDC25C 24234451 25348397 28330616 association pull down,physical interaction ComPPI,IntAct
MARK3 CDC25C 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
DYNLT1 CDC25C 25348397 N/A physical interaction ComPPI
CGN CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KIF13B CDC25C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C CCNA2 10864927 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDC25C LZTS1 14525934 17349584 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
CDC25C BRSK2 25348397 N/A physical interaction,in vitro ComPPI
CDC25C CDK1 11836499 14525934 17349584 24234451 25348397 8119945 8440392 9141461 9268380 9585407 9733650 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
CDC25C USP17L2 25348397 N/A physical interaction ComPPI
CDC25C CDS1 25348397 N/A physical interaction ComPPI
CDC25C HSP90AA2P 25348397 N/A physical interaction ComPPI
CDC25C HERC2 25348397 N/A physical interaction ComPPI
CDC25C HERC2P3 25348397 N/A physical interaction ComPPI
CDC25C BRCA1 25348397 N/A physical interaction ComPPI
CDC25C FAM27E3 25348397 N/A physical interaction ComPPI
CDC25C PHLDB3 25348397 N/A physical interaction ComPPI
CDC25C GLO1 25348397 N/A physical interaction ComPPI
CDC25C GRPEL1 25348397 N/A physical interaction ComPPI
CDC25C SLIRP 25348397 N/A physical interaction ComPPI
CDC25C TPP1 25348397 N/A physical interaction ComPPI
CDC25C SCO2 25348397 N/A physical interaction ComPPI
CDC25C LMTK2 25348397 N/A physical interaction ComPPI
CDC25C ERBB3 25348397 N/A physical interaction ComPPI
CDC25C KCTD3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C ZBTB21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C KSR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C MAST3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C LRFN1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C RALGPS2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C DENND1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C DENND4C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C PPM1H 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C SRGAP2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C GIGYF2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C EIF4E2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C SIPA1L1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C LPIN3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C CAMSAP2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C LIMA1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C NADK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C TESK2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C DCLK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C ZNF638 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C RASAL2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C SH3RF3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C MAPKAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C MAP3K21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C OSBPL6 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C KIF1C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C PLEKHA7 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C SRSF12 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C TANC2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C NAV1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C SYDE1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C INPP5E 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C TCTE1 24234451 25348397 26638075 association proximity-dependent biotin identification ComPPI,IntAct
CDC25C FAM20C 22582013 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
CDC25C MYO1B 24234451 25348397 28330616 association pull down ComPPI,IntAct
CDC25C TPM4 24234451 25348397 28330616 association pull down ComPPI,IntAct
CDC25C MYO1C 24234451 25348397 28330616 association pull down ComPPI,IntAct
PPP2R5D CDC25C 17110335 18056802 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53 CDC25C 10853038 14525934 16753148 N/A experimental interaction detection HPRD
CDC25C FZR1 11842186 27898060 N/A N/A OmniPath
PLK1 CDC25C 11202906 11897663 12595692 14532005 14968113 16753148 17307877 18062778 19503101 19597481 27898060 stimulant N/A OmniPath
MAPK10 CDC25C 20220133 27898060 inhibition N/A OmniPath
CHEK1 CDC25C 10557092 10681541 11016625 11333986 11390642 11551930 11836499 12660173 15150265 15629715 15705874 16330544 16705183 17035231 19330022 20068082 20068231 27898060 9278511 9278512 9543386 inhibition N/A OmniPath
MAPKAPK2 CDC25C 15629715 27898060 inhibition N/A OmniPath
CHEK2 CDC25C 10557092 10681541 10744722 11333986 11438675 11551930 12024051 12402044 12835754 12909615 16705183 20068231 25361978 27898060 9278512 9543386 9836640 inhibition,stimulant N/A OmniPath
MAPK9 CDC25C 20220133 27898060 inhibition N/A OmniPath
CDC25C PIN1 10037602 11604498 27898060 9482729 9499405 N/A N/A OmniPath
PIN1 CDC25C 10037602 11604498 27898060 9482729 9499405 N/A N/A OmniPath
PLK3 CDC25C 10557092 11333986 11551930 12742231 14968113 15629715 20068231 27898060 9278512 9543386 stimulant N/A OmniPath
CDK2 CDC25C 16191191 20530684 27898060 8475101 stimulant N/A OmniPath
TP53 CDC25C 10853038 16753148 18431400 27898060 inhibition N/A OmniPath
CDC25C TP53 10853038 16753148 27898060 N/A N/A OmniPath
MAPK14 CDC25C 10557092 11333986 11551930 20068231 27898060 9278512 9543386 N/A N/A OmniPath
PPP1CB CDC25C 14592972 16467385 27898060 stimulant N/A OmniPath
CDK1 CDC25C 10037602 10864927 11836499 16964243 17349584 18212344 18669648 18691976 19574738 20068231 20668692 24710276 27898060 8119945 8440392 9141461 9268380 9585407 9733650 inhibition,stimulant N/A OmniPath
CDC25C CDK1 10037602 10864927 11836499 12036951 1312880 16964243 17349584 18212344 18669648 18691976 19574738 20068231 27898060 8119945 8440392 9141461 9268380 9585407 9733650 stimulant N/A OmniPath
PPP1CA CDC25C 14592972 16467385 27898060 stimulant N/A OmniPath
CDC14B CDC25C 21379580 27898060 N/A N/A OmniPath
CDC25C CCNB1 10864927 18319725 1836978 27898060 8348613 8402895 stimulant N/A OmniPath
CSNK2A1 CDC25C 12766774 15064744 27898060 inhibition N/A OmniPath
MAPK8 CDC25C 20220133 27898060 inhibition N/A OmniPath
YWHAQ CDC25C 15629715 15791647 20068082 27898060 9543386 inhibition N/A OmniPath
FOXM1 CDC25C 16955137 20351091 27898060 stimulant N/A OmniPath
PPP1CC CDC25C 14592972 16467385 27898060 stimulant N/A OmniPath
PKN1 CDC25C 10557092 11333986 11551930 15791647 20068231 27898060 9278512 9543386 N/A N/A OmniPath
MARK3 CDC25C 10557092 10681541 10744722 10770932 10786669 11333986 11551930 12049736 12766774 12941695 14681223 14987992 15073169 15282313 15296723 15319445 15471901 15735676 15870257 15940258 15975956 16205633 16632641 16705183 16794575 16968750 17172433 17237275 17242184 17409144 17976513 18071308 18510930 19933706 20068231 20530684 20637859 20639859 23993743 25299772 25633196 25809478 25940704 27898060 7982962 9278511 9278512 9543386 9836640 N/A N/A OmniPath
BRSK2 CDC25C 10557092 11333986 11551930 15150265 20068231 27898060 9278512 9543386 N/A N/A OmniPath
BRSK1 CDC25C 10557092 11333986 11551930 15150265 20068231 27898060 9278512 9543386 inhibition N/A OmniPath

Visualization










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