GENE：SLC40A1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC40A1 |
| FullNmae | solute carrier family 40 member 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10909 |
| EnsembleID | ENSG00000138449 |
| Uniprot | Q9NP59 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC40A1 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC40A1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC40A1 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC40A1 | GO:0002260,GO:0003158,GO:0005381,GO:0005381,GO:0005381,GO:0005515,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006366,GO:0006879,GO:0006915,GO:0008021,GO:0015093,GO:0016020,GO:0016323,GO:0016323,GO:0016323,GO:0017046,GO:0017046,GO:0034395,GO:0034755,GO:0034755,GO:0042802,GO:0043066,GO:0045944,GO:0046872,GO:0051649,GO:0060345,GO:0060586,GO:1903988 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC40A1 | hsa:30061 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
| SLC40A1 | hsa:30061 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLC40A1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | SLC40A1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | SLC40A1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | SLC40A1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | SLC40A1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| NR1I2 | SLC40A1 | 19129222 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | SLC40A1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SLC40A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC40A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC40A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SLC40A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLC40A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SLC40A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AQP1 | SLC40A1 | 23219802 24234451 25348397 | association | cross-linking study | ComPPI,IntAct |
| SLC4A1 | SLC40A1 | 23219802 24234451 25348397 | association | cross-linking study | ComPPI,IntAct |
| HAMP | SLC40A1 | 14525934 15514116 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| SLC40A1 | GOLM1 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| SLC40A1 | APP | 20817278 24234451 24867889 25348397 27898060 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation | ComPPI,IntAct,OmniPath |
| SLC40A1 | CP | 20817278 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| SLC40A1 | ALDOA | 23219802 24234451 25348397 | association | cross-linking study | ComPPI,IntAct |
| CP | SLC40A1 | 20817278 24921009 27898060 | N/A | N/A | OmniPath |