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GENE：GRK4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GRK4
FullNmae G protein-coupled receptor kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4543
EnsembleID ENSG00000125388
Uniprot P32298

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GRK4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GRK4 GO:0004672,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0006468,GO:0007165,GO:0008277,GO:0009966,GO:0016310,GO:0022400,GO:0031623,GO:0050254,GO:0097381

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GRK4 hsa:2868 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
GRK4 hsa:2868 path:hsa04144 Endocytosis - Homo sapiens (human)
GRK4 hsa:2868 path:hsa05032 Morphine addiction - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IKBKG GRK4 20098747 23180781 physical association protein array InnateDB
GRK4 GNAI1 10508237 10644702 15337520 16183910 17084806 18538863 23109003 chemical activation reaction N/A SignaLink
GRK4 GNAI2 10508237 10644702 15337520 16183910 17084806 18538863 23109003 chemical activation reaction N/A SignaLink
GRK4 GNAI3 10508237 10644702 15337520 16183910 17084806 18538863 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR GRK4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 GRK4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GRK4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GRK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC GRK4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000D2680 GRK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE GRK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 GRK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E GRK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 GRK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 GRK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC GRK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA GRK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 GRK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000010BD8D GRK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000215483 GRK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003E226A GRK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C02E4 GRK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005DEC41 GRK4 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GRK4 GRK4 22135298 phosphorylation N/A PhosphoSite
GRK4 BDKRB2 22135298 phosphorylation N/A PhosphoSite
GRK4 FSHR 25361965 interaction type N/A PTMCode2
FSHR GRK4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CALM1 GRK4 25348397 N/A physical interaction ComPPI
HSP90AB1 GRK4 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HSP90AA1 GRK4 25348397 N/A physical interaction ComPPI
ADRB2 GRK4 25348397 N/A physical interaction ComPPI
NEDD4 GRK4 25348397 N/A physical interaction ComPPI
BDKRB2 GRK4 25348397 N/A in vitro,in vivo ComPPI
FSHR GRK4 25348397 N/A physical interaction,in vitro ComPPI
GRK4 IKBKG 20098747 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
GRK4 HSP90AA2P 25348397 N/A physical interaction ComPPI
GRK4 BDKRB2 11517230 15161928 27898060 inhibition N/A OmniPath

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