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GENE：GADD45A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GADD45A
FullNmae growth arrest and DNA damage inducible alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4095
EnsembleID ENSG00000116717
Uniprot P24522

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GADD45A pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GADD45A parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GADD45A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GADD45A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GADD45A GO:0000079,GO:0000122,GO:0005515,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0006281,GO:0006915,GO:0007098,GO:0016525,GO:0016607,GO:0019900,GO:0033140,GO:0042770,GO:0042803,GO:0043065,GO:0043537,GO:0046330,GO:0046982,GO:0051726,GO:0071260,GO:0071479,GO:0071901,GO:1900745,GO:1990841,GO:2000379

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GADD45A hsa:1647 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
GADD45A hsa:1647 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
GADD45A hsa:1647 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
GADD45A hsa:1647 path:hsa04110 Cell cycle - Homo sapiens (human)
GADD45A hsa:1647 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
GADD45A hsa:1647 path:hsa04210 Apoptosis - Homo sapiens (human)
GADD45A hsa:1647 path:hsa04218 Cellular senescence - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05200 Pathways in cancer - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05210 Colorectal cancer - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05213 Endometrial cancer - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05214 Glioma - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05216 Thyroid cancer - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05218 Melanoma - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05224 Breast cancer - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
GADD45A hsa:1647 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDK1 GADD45A 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17660363 18414028 18543256 18590585 18995830 19004803 19652693 19686080 23485469 26192618 7575488 interaction type N/A ACSN
PCNA GADD45A 10779360 11756412 12124778 14624239 14726013 15703371 15917306 16697054 17599061 19004803 19652693 1974050 19847258 20457011 22021614 22615860 23414611 23485469 26192618 association N/A ACSN
GADD45A WRN 10779360 12124778 15917306 17599061 19004803 19652693 23485469 26192618 interaction type N/A ACSN
TP53 GADD45A 16990795 23180781 physical association anti tag coimmunoprecipitation InnateDB
GADD45A NUCB2 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
GADD45A SH3GLB1 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
GADD45A MAPK14 15735649 23109003 inhibition N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR GADD45A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 GADD45A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 GADD45A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GADD45A 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 GADD45A 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
JUND GADD45A 17084916 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
MAX GADD45A 15021909 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC GADD45A 15021909 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 GADD45A 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 GADD45A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GADD45A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GADD45A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GADD45A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GADD45A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GADD45A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GADD45A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GADD45A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 GADD45A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR GADD45A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 GADD45A 10327059 10566557 12007564 15031557 16581545 17344317 18225552 18350249 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATM GADD45A 20164679 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 GADD45A 10962562 11777930 12647291 17428466 18025037 18350249 trascriptional regulation,stimulation inferred by curator TFlink
NFYA GADD45A 11420680 11525640 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 GADD45A 11420680 11525640 trascriptional regulation,stimulation inferred by curator TFlink
POU5F1 GADD45A 11704867 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 GADD45A N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 GADD45A N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARA GADD45A N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARD GADD45A N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG GADD45A N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA GADD45A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000285DCB GADD45A 21274007 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000285DCB GADD45A 21274007 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00005CC20C GADD45A 20542001 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS000003ABC4 GADD45A 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 GADD45A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000001C659 GADD45A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001597DC GADD45A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD GADD45A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 GADD45A 25416803 27505319 mrna cleavage,inhibition nucleotide sequence identification,quantitative reverse transcription pcr TarBase
URS00004900F1 GADD45A 25416803 25469565 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00000EED18 GADD45A 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
GADD45A PCNA 25361965 interaction type N/A PTMCode2
PCNA GADD45A 25361965 interaction type N/A PTMCode2
GADD45A MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 GADD45A 25361965 interaction type N/A PTMCode2
CDKN1A GADD45A 25361965 interaction type N/A PTMCode2
GADD45A CDKN1A 25361965 interaction type N/A PTMCode2
GADD45GIP1 GADD45A 25361965 interaction type N/A PTMCode2
GADD45A GADD45GIP1 25361965 interaction type N/A PTMCode2
MAPK14 GADD45A 25361965 interaction type N/A PTMCode2
GADD45A MAPK14 25361965 interaction type N/A PTMCode2
CCNB1 GADD45A 25361965 interaction type N/A PTMCode2
GADD45A CCNB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LMO4 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTL GADD45A 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SH3GLB1 GADD45A 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
RPS7 GADD45A 25348397 N/A physical interaction ComPPI
GADD45G GADD45A 25348397 N/A physical interaction ComPPI
NPM1 GADD45A 14525934 15644315 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,OmniPath
RARA GADD45A 25348397 N/A physical interaction ComPPI
VIM GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PCNA GADD45A 10828065 14525934 25348397 7478510 7973727 N/A two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CDKN1A GADD45A 10912791 10973963 14525934 25348397 27898060 7478594 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PSMC3 GADD45A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2D1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
H2AC11 GADD45A 10022855 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
H4C1 GADD45A 10022855 11498536 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TLE1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK1 GADD45A 25348397 N/A physical interaction ComPPI
TDG GADD45A 21722948 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
MAPK14 GADD45A 12748288 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PPARA GADD45A 25348397 N/A in vitro ComPPI
GADD45B GADD45A 25348397 N/A physical interaction ComPPI
GAPDH GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BTRC GADD45A 25348397 N/A physical interaction ComPPI
CLEC3B GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BAG6 GADD45A 25348397 N/A physical interaction ComPPI
MAP3K4 GADD45A 12052864 14525934 24234451 25348397 9827804 physical association two hybrid,experimental interaction detection,dihydrofolate reductase reconstruction,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
EEF1A1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ADAP1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
H2BC21 GADD45A 10022855 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
QARS1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
JMJD1C GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MDM2 GADD45A 25348397 N/A physical interaction ComPPI
H3-4 GADD45A 10022855 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ZHX1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP2K6 GADD45A 12052864 24234451 25241761 25348397 physical association dihydrofolate reductase reconstruction,physical interaction,proximity ligation assay ComPPI,IntAct
CCNB1 GADD45A 25348397 N/A physical interaction ComPPI
AICDA GADD45A 21722948 24234451 25348397 association,physical association anti tag coimmunoprecipitation ComPPI,IntAct
AURKA GADD45A 25348397 N/A physical interaction ComPPI
ING4 GADD45A 23388825 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ERCC5 GADD45A 17268471 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
MICAL1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TIAL1 GADD45A 25348397 N/A physical interaction ComPPI
SPTBN4 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MASP1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MPP1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IGHM GADD45A 21900206 24234451 25348397 physical association two hybrid ComPPI,IntAct
ESR1 GADD45A 25348397 N/A physical interaction ComPPI
GNB2 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MTOR GADD45A 25348397 N/A physical interaction ComPPI
NRBP1 GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
STAT3 GADD45A 25348397 N/A physical interaction ComPPI
NUCB2 GADD45A 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
KHSRP GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FAS GADD45A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDK11B GADD45A 25348397 N/A physical interaction ComPPI
DCTN2 GADD45A 14525934 16189514 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
EEF1G GADD45A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LNX2 GADD45A 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
ASCC2 GADD45A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GADD45GIP1 GADD45A 12716909 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
HNRNPA0 GADD45A 25348397 N/A physical interaction ComPPI
GADD45A H1-1 10022855 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GADD45A CDK1 10362260 10973963 14525934 25348397 N/A affinity chromatography technology,coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD
GADD45A RXRA 10872826 14525934 21900206 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
GADD45A MIDN 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A RPS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A IGSF21 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A TP53 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A CENPB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A RAI1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A SYNE4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A EEF1A1P5 25348397 N/A physical interaction ComPPI
GADD45A FBN3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A DNAJC13 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A ERG28 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A UBR1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A GBP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A PFKFB4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A CHD3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A FAM83D 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A ZNF135 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A RBPJ 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A PTN 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A DNMT1 25348397 N/A physical interaction ComPPI
GADD45A CDK11A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A PTPRK 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GADD45A APEX1 25348397 N/A physical interaction ComPPI
GADD45A HNRNPA1 25348397 N/A physical interaction ComPPI
GADD45A CDAN1 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
GADD45A CRELD2 21900206 24234451 25348397 physical association two hybrid ComPPI,IntAct
GADD45A PARVG 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GADD45A GADD45A 11498536 14525934 N/A experimental interaction detection HPRD
FOXO3 GADD45A 14976264 27898060 stimulant N/A OmniPath
HNRNPA0 GADD45A 21173571 27898060 stimulant N/A OmniPath
TRIM28 GADD45A 17942393 27898060 inhibition N/A OmniPath
TP53 GADD45A 14627995 15603758 16990795 21900206 27898060 stimulant N/A OmniPath
GADD45A TP53 16990795 21900206 27898060 N/A N/A OmniPath
GADD45A MAPK14 11163539 12748288 15735649 20626350 27898060 inhibition,stimulant N/A OmniPath
MAPK14 GADD45A 11163539 12748288 27898060 stimulant N/A OmniPath
TIAL1 GADD45A 21173571 27898060 inhibition N/A OmniPath
HNRNPD GADD45A 21173571 27898060 inhibition N/A OmniPath
SMARCA4 GADD45A 18414052 27898060 stimulant N/A OmniPath
GADD45A CDK1 10362260 10747892 10973963 12124778 18942077 27898060 inhibition N/A OmniPath
BRCA1 GADD45A 10528224 15650754 27898060 stimulant N/A OmniPath
PARN GADD45A 20932473 27898060 stimulant N/A OmniPath
TIA1 GADD45A 21173571 27898060 inhibition N/A OmniPath
GADD45A NUCB2 21988832 27898060 N/A N/A OmniPath

Visualization










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