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GENE：MDM4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MDM4
FullNmae MDM4 regulator of p53
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6974
EnsembleID ENSG00000198625
Uniprot O15151

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MDM4 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MDM4 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MDM4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MDM4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MDM4 GO:0000122,GO:0003170,GO:0003181,GO:0003203,GO:0003281,GO:0003283,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0008270,GO:0008285,GO:0016567,GO:0017053,GO:0019899,GO:0030330,GO:0042177,GO:0043066,GO:0045892,GO:0045892,GO:0050821,GO:0051726,GO:0065003,GO:0071456

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MDM4 hsa:4194 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
MDM4 hsa:4194 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR MDM4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 MDM4 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 MDM4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MDM4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MDM4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MDM4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MDM4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 MDM4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MDM4 18971253 20036872 20372076 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MDM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP73 MDM4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002B2B5C MDM4 21084273 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000EED18 MDM4 19461653 22870278 23592263 24532687 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00002B2B5C MDM4 21084273 23724042 25416803 25670033 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000F31F4 MDM4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 MDM4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D MDM4 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 MDM4 23592263 23622248 24398324 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00002E92A8 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 MDM4 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000166778 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000759F6E MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001597DC MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000E1E9E MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002C7B2B MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F5B39 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 MDM4 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 MDM4 23592263 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000345DEB MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F9738 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC MDM4 23592263 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000042935A MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000013D17D MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004F859B MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004A6E26 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BE495 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032D69B MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000519450 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000019F055 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 MDM4 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000005CF5F MDM4 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000065D58 MDM4 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AEA5 MDM4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 MDM4 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000365675 MDM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E MDM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 MDM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000079D48 MDM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 MDM4 25416803 25670033 27418678 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS000008F0CF MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000003E1A9 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000008DA94 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000012A1DD MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000308E4D MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006F90B MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003808EC MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000140295 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001EE123 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000037E170 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002AAD6B MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000065FDF MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000020579D MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C7662 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002E1509 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000015188E MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000001A7A MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000049FAE8 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006DA05 MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005194EC MDM4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000032AE90 MDM4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000024DFCE MDM4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000002569A MDM4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 MDM4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075C1E1 MDM4 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK1 MDM4 22135298 phosphorylation N/A PhosphoSite
CDK1 MDM4 22135298 phosphorylation N/A PhosphoSite
CHEK2 MDM4 22135298 phosphorylation N/A PhosphoSite
ABL1 MDM4 22135298 phosphorylation N/A PhosphoSite
MAPK14 MDM4 22135298 phosphorylation N/A PhosphoSite
CDK4 MDM4 22135298 phosphorylation N/A PhosphoSite
CSNK1A1 MDM4 22135298 phosphorylation N/A PhosphoSite
ATM MDM4 22135298 phosphorylation N/A PhosphoSite
AKT1 MDM4 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
DAXX MDM4 18566590 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CAPN7 MDM4 25348397 N/A physical interaction ComPPI
KPNA3 MDM4 16511560 24234451 25348397 physical association pull down ComPPI,IntAct
PPP1CC MDM4 25348397 N/A physical interaction ComPPI
CDKN1A MDM4 25348397 N/A physical interaction ComPPI
MAGEA1 MDM4 25348397 N/A physical interaction ComPPI
YWHAG MDM4 14525934 16227609 16511560 16511572 16943424 21148311 22556425 24190973 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
PPP1CB MDM4 25348397 N/A physical interaction ComPPI
RPS15 MDM4 25348397 N/A physical interaction ComPPI
MKRN3 MDM4 22493164 24234451 25348397 27107012 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
UBE2D1 MDM4 12393902 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD4 MDM4 25348397 N/A physical interaction ComPPI
HSP90AB1 MDM4 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SPATA46 MDM4 25348397 N/A physical interaction ComPPI
RNF115 MDM4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CASP3 MDM4 11840332 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RB1 MDM4 14525934 16510145 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
EP300 MDM4 12483531 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD3 MDM4 12483531 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
COP1 MDM4 25348397 N/A physical interaction ComPPI
USP7 MDM4 14525934 15916963 18566590 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
UBE2D2 MDM4 20705607 24234451 25348397 ubiquitination reaction molecular sieving,physical interaction,ubiquitinase assay ComPPI,IntAct
CCNDBP1 MDM4 25348397 N/A physical interaction ComPPI
YWHAB MDM4 14525934 16511560 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
YWHAZ MDM4 14525934 16511560 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CDKN2A MDM4 25348397 N/A physical interaction ComPPI
PRKAA1 MDM4 25348397 N/A physical interaction ComPPI
UBC MDM4 17110929 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
HSP90AA1 MDM4 25348397 N/A physical interaction ComPPI
E2F1 MDM4 12532331 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
PPP1CA MDM4 25348397 N/A physical interaction ComPPI
HNRNPL MDM4 25348397 N/A physical interaction ComPPI
TP73 MDM4 11223036 14525934 25348397 N/A affinity chromatography technology,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PPARD MDM4 25348397 N/A physical interaction ComPPI
RAD54B MDM4 25348397 N/A physical interaction ComPPI
ATM MDM4 14525934 15788536 16163388 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
YWHAQ MDM4 14525934 16511560 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MNAT1 MDM4 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MDM4 CHEK1 14525934 16163388 16511572 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro ComPPI,HPRD,IntAct
MDM4 CHEK2 14525934 16163388 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MDM4 AKT1 14525934 16163388 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MDM4 YWHAE 14525934 16227609 16511560 16511572 18356162 24234451 25348397 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MDM4 YWHAH 14525934 16511560 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MDM4 SFN 14525934 16511572 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MDM4 ARF1 11297540 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
MDM4 MDM2 10218570 10608892 12393902 12483531 14525934 15604276 17159902 18566590 21988832 22493164 22902369 24234451 25348397 colocalization,association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,two hybrid array,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MDM4 TP53 11528400 12393902 14525934 15604276 15916963 17080083 17110929 17875722 19255450 19521340 20515689 20705607 24234451 24667498 25348397 25609649 8895579 9226370 ubiquitination reaction,colocalization,association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,isothermal titration calorimetry,nuclear magnetic resonance,pull down,physical interaction,enzyme linked immunosorbent assay,fluorescence microscopy,tandem affinity purification,ubiquitinase assay ComPPI,HPRD,IntAct
MDM4 CDKN2A 25348397 N/A physical interaction ComPPI
MDM4 CSNK1A1 14525934 16511560 17110929 24234451 25348397 physical association affinity chromatography technology,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
MDM4 PSMC5 25348397 N/A physical interaction ComPPI
MDM4 PSMD2 25348397 N/A physical interaction ComPPI
MDM4 TP63 25348397 N/A physical interaction ComPPI
MDM4 USP2 25348397 N/A physical interaction ComPPI
MDM4 RCHY1 25348397 N/A physical interaction ComPPI
MDM4 ABL1 25348397 N/A physical interaction ComPPI
MDM4 UBE2D3 25348397 N/A physical interaction ComPPI
MDM4 APP 25348397 N/A physical interaction ComPPI
MDM4 HSP90AA2P 25348397 N/A physical interaction ComPPI
MDM4 BCL2 19521340 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MDM4 RPL37 25348397 N/A physical interaction ComPPI
MDM4 RPS20 25348397 N/A physical interaction ComPPI
MDM4 LRSAM1 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MDM4 TRIM55 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MDM4 TRIM46 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MDM4 CD160 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MDM4 FSBP 25348397 N/A physical interaction ComPPI
MDM4 SMARCA2 25348397 N/A physical interaction ComPPI
MDM4 NBN 25348397 N/A physical interaction ComPPI
MDM4 MRE11 25348397 N/A physical interaction ComPPI
MDM4 RAD50 25348397 N/A physical interaction ComPPI
MDM4 USP22 25348397 N/A physical interaction ComPPI
MDM4 MAGEB1 25348397 N/A physical interaction ComPPI
MDM4 FAM193A 25348397 N/A physical interaction ComPPI
MDM4 ASRGL1 25348397 N/A physical interaction ComPPI
MDM4 EIF2AK4 25348397 N/A physical interaction ComPPI
MDM4 HBB 25348397 N/A physical interaction ComPPI
MDM4 CDK1 14525934 15735705 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MDM4 UBA1 20705607 24234451 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
MDM4 NAA10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MDM4 VPS26C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MDM4 C1ORF109 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MDM4 ZKSCAN3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WDR5 MDM4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PELI1 MDM4 25348397 N/A physical interaction ComPPI
CSNK1A1 MDM4 16024788 16511560 17110929 21925390 23028042 25825738 27898060 stimulant N/A OmniPath
CHEK1 MDM4 16163388 16511572 18356162 27898060 inhibition N/A OmniPath
CHEK2 MDM4 16163388 16511560 16511572 18356162 27898060 inhibition,stimulant N/A OmniPath
CASP3 MDM4 11840332 27898060 N/A N/A OmniPath
MDM4 MDM2 10218570 10608892 10827196 11606419 12370303 12393902 12483531 12860999 12874296 15604276 15735705 16055726 16227609 16511560 17159902 17301054 17616658 18219319 19432880 19573810 19619542 19683495 19838211 20473904 20484049 20697359 20705607 20724842 21730132 21925390 21988832 22120712 22266850 22333590 22493164 22666487 23028042 23671280 23946421 24755078 24813712 25105592 25384516 25512388 25659040 25703327 25809483 25825738 25981963 26001071 27898060 inhibition,stimulant N/A OmniPath
MDM2 MDM4 10218570 10608892 10827196 11606419 12370303 12393902 12483531 12860999 12874296 12963717 15604276 15735705 16055726 16227609 16511560 17159902 17301054 17616658 18219319 19432880 19573810 19619542 19683495 19838211 20473904 20484049 20697359 20705607 20724842 21730132 21925390 21988832 22120712 22266850 22333590 22493164 22666487 23028042 23671280 23946421 24755078 24813712 25105592 25384516 25512388 25659040 25703327 25809483 25825738 25981963 26001071 27898060 inhibition,stimulant N/A OmniPath
ATM MDM4 15788536 16082221 16163388 16511560 16943424 27898060 inhibition,stimulant N/A OmniPath
AKT1 MDM4 16163388 16227609 16511560 16511572 18356162 23028042 27898060 stimulant N/A OmniPath
MDM4 TP53 10075736 10608892 10827196 11223036 11528400 12370303 12393902 12874296 12963717 15604276 15916963 16024788 16227609 17080083 17110929 17301054 17875722 18485870 18677113 19075013 19153082 19255450 19305137 19432880 19521340 20174603 20515689 20724842 21075307 21088494 21925390 21965653 22266850 22374672 22807444 23028042 23671280 23946421 24127580 24445145 24659749 24667498 25464845 25609649 25825738 26148237 26186194 27898060 8895579 9226370 inhibition N/A OmniPath
ABL1 MDM4 19075013 20841568 26148237 27898060 inhibition N/A OmniPath
CDK1 MDM4 15735705 27898060 inhibition N/A OmniPath
USP7 MDM4 15916963 16082221 20713061 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008BAD26 MDM4 27087310 direct interaction,inhibition N/A NPInter

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