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GENE：AP4S1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol AP4S1
FullNmae adaptor related protein complex 4 subunit sigma 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:575
EnsembleID ENSG00000100478
Uniprot Q9Y587

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
AP4S1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
AP4S1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
AP4S1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
AP4S1 GO:0005802,GO:0006605,GO:0008104,GO:0016192,GO:0016192,GO:0030124,GO:0030124,GO:0031904,GO:0032588,GO:0043231,GO:0043231

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
AP4S1 hsa:11154 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR AP4S1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 AP4S1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 AP4S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA AP4S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF AP4S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 AP4S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 AP4S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS AP4S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 AP4S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A AP4S1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000041CB9C AP4S1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000ECE9C AP4S1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 AP4S1 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC73 AP4S1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APPBP2 AP4S1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL10 AP4S1 25348397 N/A physical interaction ComPPI
GRB2 AP4S1 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GTF2I AP4S1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SLC9A1 AP4S1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TMPO AP4S1 25348397 N/A physical interaction ComPPI
MECP2 AP4S1 25348397 N/A physical interaction ComPPI
TGOLN2 AP4S1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HLTF AP4S1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AP4E1 AP4S1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SUV39H2 AP4S1 25348397 N/A physical interaction ComPPI
AFP AP4S1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APP AP4S1 25348397 N/A physical interaction ComPPI
TMPO AP4S1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HTR6 AP4S1 24234451 28298427 physical association ubiquitin reconstruction IntAct

Visualization










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