Gene Information gene info

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GENE：KCNA4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KCNA4
FullNmae potassium voltage-gated channel subfamily A member 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6222
EnsembleID ENSG00000182255
Uniprot P22459

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KCNA4 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KCNA4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KCNA4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KCNA4 GO:0005249,GO:0005249,GO:0005251,GO:0005515,GO:0005886,GO:0005886,GO:0006813,GO:0008076,GO:0008076,GO:0008076,GO:0016020,GO:0030424,GO:0030424,GO:0030955,GO:0034765,GO:0043194,GO:0043197,GO:0051260,GO:0071805,GO:0071805,GO:0071805,GO:0099505,GO:0099508

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KCNA4 hsa:3739 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
KCNA4 hsa:3739 path:hsa04934 Cushing syndrome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ERBIN KCNA4 15123239 23180781 physical association peptide array InnateDB

Source Target Pmid Interactiontype Methods Database
PRDM14 KCNA4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF KCNA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF KCNA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 KCNA4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A KCNA4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 KCNA4 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000007F792 KCNA4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000072E4C KCNA4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 KCNA4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 KCNA4 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA KCNA4 22135298 phosphorylation N/A PhosphoSite
KCNA2 KCNA4 25361965 interaction type N/A PTMCode2
KCNA4 KCNA2 25361965 interaction type N/A PTMCode2
DLG4 KCNA4 25361965 interaction type N/A PTMCode2
KCNA4 DLG4 25361965 interaction type N/A PTMCode2
DLGAP1 KCNA4 25361965 interaction type N/A PTMCode2
KCNA4 DLGAP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SAT1 KCNA4 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
DLG4 KCNA4 11723117 11744724 11937501 12435606 14525934 24234451 25348397 7477295 8601796 8938729 9581762 N/A two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
ERBIN KCNA4 25348397 N/A physical interaction ComPPI
SRC KCNA4 25348397 N/A physical interaction ComPPI
KCNA2 KCNA4 10428084 10428758 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
DLGAP1 KCNA4 14525934 25348397 9024696 N/A experimental interaction detection,in vivo ComPPI,HPRD
KCNA4 DLG2 11997254 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
KCNA4 SNTG1 11352924 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KCNA4 ACTN2 11389904 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,in vitro,two hybrid ComPPI,HPRD,IntAct
KCNA4 DLG3 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KCNA4 PATJ 25348397 N/A in vitro ComPPI
KCNA4 CASK 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KCNA4 SNTA1 14525934 16637659 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
KCNA4 DLG1 12860415 14525934 24234451 24550280 25348397 7477295 physical association two hybrid,phage display,physical interaction,two hybrid ComPPI,HPRD,IntAct
KCNA4 NDUFA4L2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
KCNA4 KCNA3 25348397 N/A physical interaction ComPPI
KCNA4 KCNA1 25348397 N/A physical interaction ComPPI
KCNA4 LNX1 25348397 N/A physical interaction ComPPI
KCNA4 KCNA5 25348397 N/A physical interaction ComPPI
KCNA4 FYN 25348397 N/A physical interaction ComPPI
KCNA4 KCNRG 25348397 N/A physical interaction ComPPI
KCNA4 NEU1 25348397 N/A physical interaction ComPPI
KCNA4 KCNAB2 25348397 N/A physical interaction ComPPI
KCNA4 SIRT1 25348397 N/A physical interaction ComPPI
PRKACA KCNA4 15955806 27898060 N/A N/A OmniPath
ERBIN KCNA4 11278603 15123239 27898060 N/A N/A OmniPath

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