Gene Information gene info

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GENE：MED14

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MED14
FullNmae mediator complex subunit 14
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2370
EnsembleID ENSG00000180182
Uniprot O60244

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MED14 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MED14 GO:0003712,GO:0003712,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0016020,GO:0016592,GO:0016592,GO:0030374,GO:0032968,GO:0035019,GO:0042809,GO:0045893,GO:0045944,GO:0051123,GO:0060261,GO:0060261,GO:0070847,GO:0070847

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MED14 hsa:9282 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MED14 TSC22D3 16239257 23180781 physical association anti tag coimmunoprecipitation InnateDB
IGFBP1 MED14 16239257 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF8 MED14 16239257 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 MED14 12509459 23180781 physical association anti tag coimmunoprecipitation InnateDB
MED14 ISG15 12509459 23180781 physical association affinity chromatography technology InnateDB
MED14 IFIT2 12509459 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GRB2 MED14 20005715 interaction type N/A PSP
NCK1 MED14 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MED14 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MED14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MED14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MED14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MED14 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MED14 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004B4B85 MED14 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 MED14 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC4BD MED14 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C MED14 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 MED14 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F MED14 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 MED14 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NECAB2 MED14 25348397 N/A physical interaction ComPPI
TP53BP1 MED14 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
MED21 MED14 10082564 11555651 14988503 22939629 25348397 27898060 9710620 9734358 9891034 N/A physical interaction ComPPI,OmniPath
MED8 MED14 25348397 N/A physical interaction ComPPI
STN1 MED14 25348397 N/A physical interaction ComPPI
EMC2 MED14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXW7 MED14 25348397 N/A physical interaction ComPPI
NCK1 MED14 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 MED14 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
AR MED14 12218053 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
VDR MED14 25348397 N/A physical interaction ComPPI
HIF1A MED14 23746844 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
GATA1 MED14 17132730 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
MED1 MED14 14525934 15175163 20098423 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PPARGC1A MED14 25348397 N/A physical interaction ComPPI
MED24 MED14 24234451 24882805 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTN1 MED14 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
NTRK1 MED14 25348397 N/A physical interaction ComPPI
STAT2 MED14 12509459 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NR1I3 MED14 25348397 N/A physical interaction ComPPI
PARP1 MED14 25348397 N/A physical interaction ComPPI
SREBF1 MED14 25348397 N/A physical interaction ComPPI
PPARG MED14 25348397 N/A physical interaction ComPPI
DCTN1 MED14 25348397 N/A physical interaction ComPPI
ACTN2 MED14 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
LMO2 MED14 25348397 N/A physical interaction ComPPI
CTDP1 MED14 25348397 N/A physical interaction ComPPI
MED9 MED14 14525934 14638676 15175163 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MED11 MED14 25348397 N/A physical interaction ComPPI
MED23 MED14 24234451 24882805 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRRAP MED14 25348397 N/A physical interaction ComPPI
KAT2A MED14 18418385 24234451 25348397 association biochemical ComPPI,IntAct
HNF4A MED14 25348397 N/A physical interaction,in vitro ComPPI
MED17 MED14 25348397 N/A physical interaction ComPPI
MED28 MED14 25348397 N/A physical interaction ComPPI
MED25 MED14 24234451 24882805 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FYN MED14 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
MED14 NR3C1 10508170 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
MED14 MED10 14576168 15175163 24234451 24882805 25348397 association,physical association anti tag coimmunoprecipitation,electron microscopy,physical interaction,ion exchange chromatography ComPPI,IntAct
MED14 MED29 14525934 14576168 15175163 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
MED14 MED19 14576168 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 MED26 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 CDK8 18418385 20098423 23602568 24234451 25348397 26496610 29568061 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,biochemical,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
MED14 MED6 10082564 11555651 25348397 26344197 27898060 9234719 9734358 9891034 N/A physical interaction ComPPI,OmniPath
MED14 ESR1 25348397 N/A physical interaction ComPPI
MED14 ESR2 21182203 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
MED14 BRD4 25348397 N/A physical interaction ComPPI
MED14 MED12 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 ZC3H13 25348397 N/A physical interaction ComPPI
MED14 QKI 25348397 N/A physical interaction ComPPI
MED14 TADA2A 25348397 N/A physical interaction ComPPI
MED14 MED15 24234451 24882805 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 MED27 25348397 N/A physical interaction ComPPI
MED14 UACA 14525934 15604093 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
MED14 MED16 24234451 24882805 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 MED4 25348397 N/A physical interaction ComPPI
MED14 MED13 25348397 N/A physical interaction ComPPI
MED14 PPP6R1 25348397 N/A physical interaction ComPPI
MED14 EPAS1 25348397 N/A physical interaction ComPPI
MED14 CDK19 15175163 23602568 24234451 25348397 association,physical association physical interaction,ion exchange chromatography,tandem affinity purification ComPPI,IntAct
MED14 HECW2 25348397 N/A physical interaction ComPPI
MED14 CCNC 19047373 24234451 25348397 physical association chromatography technology,physical interaction ComPPI,IntAct
MED14 TCL1B 25348397 N/A physical interaction ComPPI
MED14 UNK 25348397 N/A physical interaction ComPPI
MED14 ACTL6B 25348397 N/A physical interaction ComPPI
MED14 MED20 25348397 N/A physical interaction ComPPI
MED14 KIF11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 LAMB3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 POLR2G 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 SUPT5H 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 BIRC5 25348397 N/A physical interaction ComPPI
MED14 ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
MED14 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
H3C1 MED14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MED18 MED14 25348397 N/A physical interaction ComPPI
MED7 MED14 25348397 N/A physical interaction ComPPI
ARM MED14 24234451 25294943 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NUDCD1 MED14 24234451 29021621 association anti tag coimmunoprecipitation IntAct
MED14 ANGPTL2 11248049 11331312 12499356 16183906 18381280 20207164 23583819 27898060 N/A N/A OmniPath
MAPK3 MED14 24049075 27898060 N/A N/A OmniPath
MED14 STAT2 12509459 27898060 stimulant N/A OmniPath
STAT2 MED14 12509459 27898060 N/A N/A OmniPath

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