Gene Information gene info

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GENE：WNT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol WNT1
FullNmae Wnt family member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12774
EnsembleID ENSG00000125084
Uniprot P04628

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
WNT1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
WNT1 GO:0000578,GO:0001658,GO:0001934,GO:0005109,GO:0005109,GO:0005109,GO:0005125,GO:0005125,GO:0005576,GO:0005615,GO:0005737,GO:0005788,GO:0005796,GO:0005886,GO:0007267,GO:0007520,GO:0008284,GO:0008284,GO:0009611,GO:0009986,GO:0010592,GO:0010812,GO:0016015,GO:0019904,GO:0021527,GO:0021536,GO:0021551,GO:0021588,GO:0021797,GO:0022004,GO:0022408,GO:0030182,GO:0030512,GO:0030514,GO:0030666,GO:0030901,GO:0031100,GO:0033077,GO:0033278,GO:0036520,GO:0042472,GO:0042770,GO:0043066,GO:0043568,GO:0045165,GO:0045444,GO:0045599,GO:0045747,GO:0045893,GO:0045893,GO:0045893,GO:0045944,GO:0048018,GO:0048018,GO:0048018,GO:0048146,GO:0048664,GO:0051091,GO:0060061,GO:0060070,GO:0060070,GO:0060070,GO:0060070,GO:0060070,GO:0060348,GO:0061184,GO:0070062,GO:0070365,GO:0071375,GO:0071425,GO:1902035,GO:1903377,GO:1904953,GO:1904953,GO:1904954,GO:1990403,GO:2000059,GO:2000773

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
WNT1 hsa:7471 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
WNT1 hsa:7471 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
WNT1 hsa:7471 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
WNT1 hsa:7471 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
WNT1 hsa:7471 path:hsa04916 Melanogenesis - Homo sapiens (human)
WNT1 hsa:7471 path:hsa04934 Cushing syndrome - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05010 Alzheimer disease - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05200 Pathways in cancer - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05224 Breast cancer - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
WNT1 hsa:7471 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SIX3 WNT1 12050133 20710043 20925119 26192618 interaction type N/A ACSN
WNT1 CD36 23180781 25721714 physical association anti tag coimmunoprecipitation InnateDB
PAX3 WNT1 23180781 25721714 physical association anti tag coimmunoprecipitation InnateDB
WNT1 WNT1 15578921 21078818 21902831 22944199 26467481 interaction type,bind,up-regulates activity N/A Signor
FRZB WNT1 23331499 9326585 stimulation N/A SignaLink,SignaLink
SFRP1 WNT1 10347172 10523516 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
WNT1 LRP6 11029007 11448771 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
WNT1 RYK 15454084 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
YBX1 WNT1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 WNT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF WNT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 WNT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 WNT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A WNT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 WNT1 N/A trascriptional regulation,stimulation inferred by curator TFlink
LEF1 WNT1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000000B1C9 WNT1 19398721 rna interference,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00003380CC WNT1 22276989 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D WNT1 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000EED18 WNT1 19336450 19398721 \N rna interference,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D WNT1 18927107 mrna cleavage,inhibition N/A miR2Disease
URS00000EED18 WNT1 18927107 19336450 19398721 25416803 28199987 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000000B1C9 WNT1 19398721 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003380CC WNT1 22276989 25416803 27687586 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000096022 WNT1 23851184 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000012A1DD WNT1 23851184 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000000C73C WNT1 24416131 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003BBF48 WNT1 25416803 26707142 28199399 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001C770D WNT1 25416803 27713126 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000521626 WNT1 25416803 26664144 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000023BE29 WNT1 25416803 25529604 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
WNT1 LRP5 25361965 interaction type N/A PTMCode2
LRP5 WNT1 25361965 interaction type N/A PTMCode2
LRP6 WNT1 25361965 interaction type N/A PTMCode2
WNT1 LRP6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ROR2 WNT1 25348397 N/A physical interaction ComPPI
WIF1 WNT1 25348397 N/A physical interaction ComPPI
SFRP2 WNT1 10654605 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
LRP5 WNT1 11336703 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
WNT3A WNT1 10557084 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PORCN WNT1 10866835 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SFRP1 WNT1 10347172 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LRP6 WNT1 11029007 11448771 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
POLR2C WNT1 25348397 N/A physical interaction ComPPI
FZD8 WNT1 14525934 15454084 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
WNT1 UBR3 25348397 N/A physical interaction ComPPI
FZD9 WNT1 14525934 25348397 9147651 N/A experimental interaction detection,in vivo ComPPI,HPRD
RYK WNT1 14525934 15454084 N/A experimental interaction detection HPRD
WNT1 PRKACA 21902831 27898060 stimulant N/A OmniPath
WNT1 CTNNB1 11149923 27898060 stimulant N/A OmniPath
SFRP1 WNT1 10347172 10523516 1052352 27898060 inhibition,stimulant N/A OmniPath
WNT1 LRP5 11336703 15578921 21078818 27898060 stimulant N/A OmniPath
WNT1 PAX8 18495817 27898060 stimulant N/A OmniPath
WNT1 LRP6 11029007 11448771 15578921 16126904 18505367 21078818 27898060 stimulant N/A OmniPath
SFRP2 WNT1 10654605 27898060 inhibition N/A OmniPath
WNT1 FOXI2 18495817 27898060 inhibition N/A OmniPath
WNT1 SOX9 18495817 27898060 stimulant N/A OmniPath
WNT1 DLX5 18495817 27898060 stimulant N/A OmniPath
WNT1 PAX2 18495817 27898060 stimulant N/A OmniPath
WNT1 NOTCH1 18495817 27898060 stimulant N/A OmniPath
NOTCH1 WNT1 18495817 27898060 stimulant N/A OmniPath
WNT1 JAG1 18495817 27898060 stimulant N/A OmniPath
WNT1 HES1 18495817 27898060 stimulant N/A OmniPath
FRZB WNT1 27898060 9326585 inhibition,stimulant N/A OmniPath
WNT1 FZD3 14642436 15578921 27898060 stimulant N/A OmniPath
WNT1 RYK 15454084 27898060 stimulant N/A OmniPath
WNT1 FZD8 11448771 15454084 27898060 stimulant N/A OmniPath
WNT1 FZD1 10557084 15578921 16936075 22944199 24032637 27898060 stimulant N/A OmniPath
WNT1 FZD6 22944199 27898060 stimulant N/A OmniPath
WNT1 FZD9 27898060 9147651 stimulant N/A OmniPath

Visualization










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