GENE:SMG7
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SMG7 |
| FullNmae | SMG7 nonsense mediated mRNA decay factor |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16792 |
| EnsembleID | ENSG00000116698 |
| Uniprot | Q92540 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SMG7 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SMG7 | GO:0000184,GO:0000184,GO:0005515,GO:0005634,GO:0005697,GO:0005737,GO:0005829,GO:0005829,GO:0006406,GO:0035303,GO:0042162,GO:0042162,GO:0051721,GO:0070034 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SMG7 | hsa:9887 | path:hsa03015 | mRNA surveillance pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SMG7 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | SMG7 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | SMG7 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | SMG7 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | SMG7 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | SMG7 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SMG7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SMG7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SMG7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SMG7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SMG7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | SMG7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SMG7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SMG7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | SMG7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | SMG7 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000033EBB8 | SMG7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000600E6 | SMG7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002367FA | SMG7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000DDD35 | SMG7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000324096 | SMG7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000077AED | SMG7 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000555DA6 | SMG7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CEB74 | SMG7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004BACE | SMG7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000047944F | SMG7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CE046 | SMG7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006BE7D | SMG7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CD810 | SMG7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RBM8A | SMG7 | 16452507 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDC16 | SMG7 | 25348397 | N/A | physical interaction | ComPPI |
| BTRC | SMG7 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | SMG7 | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | SMG7 | 25348397 | N/A | physical interaction | ComPPI |
| SMG1 | SMG7 | 16452507 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MDM2 | SMG7 | 25348397 | N/A | physical interaction | ComPPI |
| ODF2 | SMG7 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| FGFR3 | SMG7 | 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| SMG6 | SMG7 | 25348397 | N/A | physical interaction | ComPPI |
| SMG5 | SMG7 | 23348841 24234451 25348397 | association,physical association | pull down,in vivo | ComPPI,IntAct |
| SSX2IP | SMG7 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| CENPJ | SMG7 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| UPF1 | SMG7 | 23348841 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| TRIM25 | SMG7 | 25348397 | N/A | physical interaction | ComPPI |
| ELAVL1 | SMG7 | 25348397 | N/A | physical interaction | ComPPI |
| TOMM20 | SMG7 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| FBXW11 | SMG7 | 25348397 | N/A | physical interaction | ComPPI |
| CEP152 | SMG7 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| SMG7 | HBB | 25348397 | N/A | physical interaction | ComPPI |
| SMG7 | PRMT6 | 25348397 | N/A | physical interaction | ComPPI |
| SMG7 | PCM1 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| SMG7 | CEP44 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| SMG7 | NINL | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| SMG7 | STIL | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| SMG7 | SEC16A | 25348397 | N/A | physical interaction | ComPPI |
| SMG7 | TP53 | 22653443 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SMG7 | MTMR4 | 25348397 | N/A | physical interaction | ComPPI |
| SMG7 | RIPK4 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
