GENE：CYBB
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CYBB |
| FullNmae | cytochrome b-245 beta chain |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2578 |
| EnsembleID | ENSG00000165168 |
| Uniprot | P04839 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CYBB | pyroptosis | 39260305 | AUC scores revealed that DCs in HT exhibited significantly elevated levels of necroptosis, ferroptosis, pyroptosis, autophagy, and PANoptosis, expressing six key PCDDEGs: TNFAIP3, CYBB, PTPN6, STAT1, TGFB1, and NLRP3. | retulator signature |
| CYBB | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CYBB | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CYBB | entotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CYBB | entotic_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CYBB | GO:0005244,GO:0005515,GO:0005635,GO:0005789,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006801,GO:0006801,GO:0006952,GO:0006954,GO:0007584,GO:0009055,GO:0009410,GO:0016175,GO:0016175,GO:0020037,GO:0022900,GO:0030425,GO:0030670,GO:0032760,GO:0034220,GO:0034765,GO:0035579,GO:0042554,GO:0042554,GO:0042554,GO:0043020,GO:0043020,GO:0043020,GO:0043020,GO:0043025,GO:0045087,GO:0045087,GO:0045087,GO:0045730,GO:0045730,GO:0045730,GO:0045766,GO:0046872,GO:0046982,GO:0050660,GO:0050665,GO:0070821,GO:0071276,GO:0071361,GO:0097038,GO:0097411,GO:1904044,GO:1904845,GO:1990776 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CYBB | hsa:1536 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa04145 | Phagosome - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa05140 | Leishmaniasis - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
| CYBB | hsa:1536 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CYBA | CYBB | 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 26192618 27331412 | interaction type | N/A | ACSN |
| CYBB | NCF1 | 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 26192618 27331412 | interaction type | N/A | ACSN |
| CYBB | NCF2 | 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 26192618 27331412 | interaction type | N/A | ACSN |
| IRF1 | CYBB | 11781315 23180781 8798551 9593745 | physical association | electrophoretic mobility supershift assay,electrophoretic mobility shift assay | InnateDB |
| CYBB | STAT1 | 11781315 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| IRF8 | CYBB | 15371411 15496449 18089853 23180781 9593745 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,electrophoretic mobility shift assay | InnateDB |
| PAK1 | CYBB | 16099876 23180781 | physical association | pull down | InnateDB |
| TLR2 | CYBB | 19265148 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SPI1 | CYBB | 15618156 23180781 9600921 | physical association | affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| ELF1 | CYBB | 15618156 23180781 | physical association | affinity chromatography technology,anti tag coimmunoprecipitation | InnateDB |
| IRF2 | CYBB | 23180781 8798551 | physical association | electrophoretic mobility supershift assay | InnateDB |
| CREBBP | CYBB | 10570299 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| HOXA9 | CYBB | 15681849 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PLA2G4A | CYBB | 12913107 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CYBB | HOXA10 | 10766757 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| CYBB | PBX1 | 10766757 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| RUBCN | CYBB | 22423966 22423967 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CYBB | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | CYBB | 10734088 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| GATA2 | CYBB | 10734088 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| IRF8 | CYBB | 9593745 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| IRF1 | CYBB | 9593745 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SPI1 | CYBB | 10233904 11926990 18971253 9593745 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | CYBB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CYBB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | CYBB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CYBB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | CYBB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CUX1 | CYBB | 14605447 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CUX1 | CYBB | 14605447 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ELF1 | CYBB | 10233904 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EP300 | CYBB | 14605447 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SATB1 | CYBB | 14605447 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000EED18 | CYBB | 24393844 25416803 | mrna cleavage,inhibition | western blot | TarBase |
| URS00002CEB74 | CYBB | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004BACE | CYBB | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000047944F | CYBB | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170D8B | CYBB | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | CYBB | 25416803 28235791 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000521626 | CYBB | 25416803 28235791 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS000029D9F1 | CYBB | 25416803 28235791 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NCF4 | CYBB | 25361965 | interaction type | N/A | PTMCode2 |
| CYBB | NCF4 | 25361965 | interaction type | N/A | PTMCode2 |
| CYBA | CYBB | 25361965 | interaction type | N/A | PTMCode2 |
| CYBB | CYBA | 25361965 | interaction type | N/A | PTMCode2 |
| NCF2 | CYBB | 25361965 | interaction type | N/A | PTMCode2 |
| CYBB | NCF2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC1 | CYBB | 25361965 | interaction type | N/A | PTMCode2 |
| CYBB | RAC1 | 25361965 | interaction type | N/A | PTMCode2 |
| NCF1 | CYBB | 25361965 | interaction type | N/A | PTMCode2 |
| CYBB | NCF1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ACTG1 | CYBB | 14525934 16179592 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ACTB | CYBB | 25348397 | N/A | physical interaction | ComPPI |
| RAC1 | CYBB | 11893732 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TNFRSF1A | CYBB | 19641494 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| IQGAP1 | CYBB | 14525934 16179592 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| NCF1 | CYBB | 25348397 | N/A | in vivo | ComPPI |
| NCF4 | CYBB | 11893732 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CYBA | CYBB | 11893732 14525934 25348397 7938008 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| NCF2 | CYBB | 11248021 11893732 11917128 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RAC2 | CYBB | 22366891 24234451 25348397 | colocalization | confocal microscopy | ComPPI,IntAct |
| LTB4R | CYBB | 25348397 | N/A | physical interaction | ComPPI |
| CYBB | CYBC1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TLR2 | CYBB | 19265148 27898060 | N/A | N/A | OmniPath |