GENE：NOX4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NOX4 |
| FullNmae | NADPH oxidase 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7891 |
| EnsembleID | ENSG00000086991 |
| Uniprot | Q9NPH5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NOX4 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NOX4 | GO:0000166,GO:0000902,GO:0003015,GO:0005515,GO:0005634,GO:0005730,GO:0005739,GO:0005789,GO:0005886,GO:0005886,GO:0005925,GO:0006801,GO:0006952,GO:0006954,GO:0008285,GO:0009055,GO:0010467,GO:0016020,GO:0016174,GO:0016175,GO:0019826,GO:0020037,GO:0022900,GO:0042554,GO:0042554,GO:0043020,GO:0045453,GO:0048471,GO:0050660,GO:0050667,GO:0051897,GO:0055007,GO:0061098,GO:0070374,GO:0071333,GO:0072341,GO:0097038,GO:1903409,GO:1990782,GO:2000573 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NOX4 | hsa:50507 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| NOX4 | hsa:50507 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| NOX4 | hsa:50507 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| NOX4 | hsa:50507 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| NOX4 | hsa:50507 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CYBA | NOX4 | 15927447 16179589 19372727 19644055 19732719 19995913 21273445 26192618 | interaction type | N/A | ACSN |
| SMAD2 | NOX4 | 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 21042762 21614932 22331441 23784029 26192618 9389648 9670020 | interaction type | N/A | ACSN |
| SMAD4 | NOX4 | 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 21042762 21614932 22331441 23784029 26192618 9389648 9670020 | interaction type | N/A | ACSN |
| NOX4 | TLR4 | 15356101 23180781 | physical association | two hybrid,gst pull down | InnateDB |
| RELA | NOX4 | 20457132 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| JUN | NOX4 | 23180781 24560583 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SMAD3 | NOX4 | 23180781 24560583 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NCF1 | NOX4 | 10029572 10336447 15258578 23109003 | chemical activation reaction | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | NOX4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SP1 | NOX4 | 21235713 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SP3 | NOX4 | 21235713 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| PRDM14 | NOX4 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CTCF | NOX4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NOX4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NOX4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | NOX4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NOX4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NOX4 | 18554521 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | NOX4 | 20622120 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | NOX4 | 20622120 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT1 | NOX4 | 19834108 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | NOX4 | 19834108 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT4 | NOX4 | 19834108 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000521626 | NOX4 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001C308D | NOX4 | 25378491 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr | TarBase |
| URS0000157026 | NOX4 | 25416803 26986073 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00001CC379 | NOX4 | 25416803 27207535 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FYN | NOX4 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MYO18A | NOX4 | 25348397 | N/A | physical interaction | ComPPI |
| TLR4 | NOX4 | 14525934 15356101 17064675 24234451 25348397 | physical association | two hybrid,experimental interaction detection,pull down,in vitro,lexa b52 complementation,two hybrid | ComPPI,HPRD,IntAct |
| NOX4 | ACTBL2 | 25348397 | N/A | physical interaction | ComPPI |
| TLR4 | NOX4 | 15356101 17064675 27898060 | N/A | N/A | OmniPath |