GENE：DUOX1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DUOX1 |
| FullNmae | dual oxidase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3062 |
| EnsembleID | ENSG00000137857 |
| Uniprot | Q9NRD9 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DUOX1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DUOX1 | GO:0004601,GO:0005509,GO:0005515,GO:0005783,GO:0005886,GO:0005886,GO:0005886,GO:0006590,GO:0006590,GO:0006952,GO:0006979,GO:0009986,GO:0016174,GO:0016174,GO:0016175,GO:0016324,GO:0019221,GO:0020037,GO:0031252,GO:0042335,GO:0042446,GO:0042554,GO:0042554,GO:0042744,GO:0043020,GO:0050661,GO:0050665,GO:0050665,GO:0051591,GO:0051591,GO:0090303,GO:0098869,GO:0106293,GO:0106294,GO:2000147 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DUOX1 | hsa:53905 | path:hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | DUOX1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DUOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DUOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DUOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DUOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKACA | DUOX1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TXNDC11 | DUOX1 | 14525934 15561711 24234451 25348397 | colocalization | anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,in vivo,confocal microscopy,two hybrid | ComPPI,HPRD,IntAct |
| DUOX1 | TPO | 14525934 15561711 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| H2BC9 | DUOX1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| PRKACA | DUOX1 | 19144650 27898060 | stimulant | N/A | OmniPath |