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GENE：FOXO4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FOXO4
FullNmae forkhead box O4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7139
EnsembleID ENSG00000184481
Uniprot P98177

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FOXO4 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FOXO4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FOXO4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FOXO4 GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0003676,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0006355,GO:0006357,GO:0006979,GO:0007095,GO:0007517,GO:0008013,GO:0008285,GO:0008286,GO:0014911,GO:0016525,GO:0016607,GO:0019899,GO:0031667,GO:0042802,GO:0043565,GO:0043565,GO:0045944,GO:0048863,GO:0051151,GO:0070317,GO:0140297,GO:1990785,GO:1990837,GO:1990841

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FOXO4 hsa:4303 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
FOXO4 hsa:4303 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
FOXO4 hsa:4303 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FOXO4 BCL6 10217147 10783894 11094066 11313479 11994454 12391153 15509806 17646672 20673124 26192618 interaction type N/A ACSN
XPO1 FOXO4 11313479 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT1 FOXO4 10217147 11313479 11689711 14690436 16272144 18988627 23180781 23331499 phosphorylation reaction,stimulation protein kinase assay InnateDB,SignaLink,SignaLink
YWHAZ FOXO4 14690436 23180781 physical association molecular sieving InnateDB
PDGFRA FOXO4 22411791 23180781 physical association anti tag coimmunoprecipitation InnateDB
CREB1 FOXO4 15126506 23331499 stimulation N/A SignaLink,SignaLink
SIRT1 FOXO4 10102273 15126506 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 FOXO4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 FOXO4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FOXO4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 FOXO4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 FOXO4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA FOXO4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FOXO4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FOXO4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FOXO4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FOXO4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TSC22D3 FOXO4 20018851 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000C7662 FOXO4 21934092 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000C7662 FOXO4 21934092 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 FOXO4 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 FOXO4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004505E4 FOXO4 23707940 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK9 FOXO4 22135298 phosphorylation N/A PhosphoSite
MAPK8 FOXO4 22135298 phosphorylation N/A PhosphoSite
AKT1 FOXO4 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
SMAD4 FOXO4 25361965 interaction type N/A PTMCode2
FOXO4 SMAD4 25361965 interaction type N/A PTMCode2
YWHAB FOXO4 25361965 interaction type N/A PTMCode2
FOXO4 YWHAB 25361965 interaction type N/A PTMCode2
FOXO4 AKT1 25361965 interaction type N/A PTMCode2
XPO1 FOXO4 25361965 interaction type N/A PTMCode2
FOXO4 XPO1 25361965 interaction type N/A PTMCode2
USP7 FOXO4 25361965 interaction type N/A PTMCode2
FOXO4 USP7 25361965 interaction type N/A PTMCode2
CTNNB1 FOXO4 25361965 interaction type N/A PTMCode2
FOXO4 CTNNB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 FOXO4 18794148 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SMAD4 FOXO4 14525934 15084259 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DDIT4L FOXO4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NLK FOXO4 25348397 N/A physical interaction ComPPI
FOXG1 FOXO4 14525934 15084259 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
REL FOXO4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CREBBP FOXO4 10973497 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
VDR FOXO4 25348397 N/A physical interaction ComPPI
SMAD3 FOXO4 14525934 15084259 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
USP7 FOXO4 25348397 N/A physical interaction ComPPI
YWHAZ FOXO4 14525934 14690436 16114898 24234451 25348397 association experimental interaction detection,biochemical,in vitro ComPPI,HPRD,IntAct
FEN1 FOXO4 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
XPO1 FOXO4 11313479 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MDM2 FOXO4 18665269 20874444 21525355 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SFN FOXO4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FOXO4 CTNNB1 14525934 15905404 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FOXO4 ESR1 11435445 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FOXO4 AKT1 10217147 11313479 11689711 14525934 16272144 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FOXO4 AKT2 25348397 N/A in vivo ComPPI
FOXO4 SIRT1 15126506 24234451 25348397 deacetylation reaction,physical association anti tag coimmunoprecipitation,physical interaction,deacetylase assay ComPPI,IntAct
FOXO4 ATXN3 21536589 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FOXO4 OGT 19932102 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
FOXO4 FOXO1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXO4 FOXO6 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
FOXO4 FOXO4 24234451 25609649 association,physical association tandem affinity purification IntAct
H1-2 FOXO4 24234451 30021884 physical association cross-linking study IntAct
CTNNB1 FOXO4 15905404 17254970 20874444 27898060 stimulant N/A OmniPath
CSNK1A1 FOXO4 19188143 27898060 inhibition N/A OmniPath
CREB1 FOXO4 15126506 27898060 inhibition,stimulant N/A OmniPath
MAPK9 FOXO4 11313479 11689711 15538382 16272144 27898060 stimulant N/A OmniPath
CDK2 FOXO4 19188143 27898060 inhibition N/A OmniPath
SIRT1 FOXO4 10102273 15126506 1512651 27898060 stimulant N/A OmniPath
AKT1 FOXO4 10217147 10518537 11313479 11689711 14690436 15538382 15688030 16272144 17522590 19144640 19664994 21620960 21798082 27898060 inhibition,stimulant N/A OmniPath
FOXO4 AKT1 10217147 11313479 11689711 14690436 15688030 16272144 21798082 27898060 N/A N/A OmniPath
STK4 FOXO4 18394876 27898060 stimulant N/A OmniPath
AKT2 FOXO4 11313479 16272144 19664994 21620960 27898060 inhibition N/A OmniPath
MAPK8 FOXO4 11689711 15538382 20959475 27898060 stimulant N/A OmniPath
FOXO4 PDGFRA 22411791 27898060 N/A N/A OmniPath
PRKAA1 FOXO4 17900900 27898060 stimulant N/A OmniPath
DYRK1A FOXO4 11313479 11689711 11896584 15538382 19188143 27898060 inhibition N/A OmniPath

Visualization










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