Gene Information gene info

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GENE：PGD

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PGD
FullNmae phosphogluconate dehydrogenase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8891
EnsembleID ENSG00000142657
Uniprot P52209

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PGD ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PGD ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PGD GO:0004616,GO:0004616,GO:0005634,GO:0005829,GO:0005829,GO:0006098,GO:0009051,GO:0009051,GO:0019322,GO:0046177,GO:0050661,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PGD hsa:5226 path:hsa00030 Pentose phosphate pathway - Homo sapiens (human)
PGD hsa:5226 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
PGD hsa:5226 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PGD hsa:5226 path:hsa01200 Carbon metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ISG15 PGD 16009940 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
AR PGD 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PGD 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PGD 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PGD 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PGD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PGD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PGD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PGD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PGD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PGD 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE PGD 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003FD55 PGD 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C PGD 22473208 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS000000B1C9 PGD 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000034B6F5 PGD 23921124 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS000043C1C3 PGD 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 PGD 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D PGD 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 PGD 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PGD PGD 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNAI3 PGD 25348397 N/A physical interaction ComPPI
CDC73 PGD 25348397 N/A physical interaction ComPPI
CTSL PGD 25348397 N/A physical interaction ComPPI
LDHB PGD 25348397 N/A physical interaction ComPPI
LDHA PGD 25348397 N/A physical interaction ComPPI
ISG15 PGD 25348397 N/A physical interaction ComPPI
STAT1 PGD 24234451 25348397 26966684 association pull down ComPPI,IntAct
TRAF6 PGD 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAG PGD 25348397 N/A physical interaction ComPPI
KEAP1 PGD 25348397 N/A physical interaction ComPPI
RBM8A PGD 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 PGD 25348397 N/A physical interaction ComPPI
PDIA3 PGD 25348397 N/A physical interaction ComPPI
YWHAB PGD 25348397 N/A physical interaction ComPPI
LSM8 PGD 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PGD GBE1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PGD USPL1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGD TERF1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
PGD CDK2 25348397 N/A physical interaction ComPPI
PGD IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGD CDK4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PGD ALDH7A1 25348397 N/A physical interaction ComPPI
PGD ALDH9A1 25348397 N/A physical interaction ComPPI
PGD EEF2 25348397 N/A physical interaction ComPPI
PGD GLA 25348397 N/A physical interaction ComPPI
PGD AHSA1 25348397 N/A physical interaction ComPPI
PGD MYG1 25348397 N/A physical interaction ComPPI
PGD CHORDC1 25348397 N/A physical interaction ComPPI
PGD EIF4H 25348397 N/A physical interaction ComPPI
PGD G6PD 25348397 N/A physical interaction ComPPI
PGD NDRG1 25348397 N/A physical interaction ComPPI
PGD SORD 25348397 N/A physical interaction ComPPI
PGD TCEA1 25348397 N/A physical interaction ComPPI
PGD THOP1 25348397 N/A physical interaction ComPPI
PGD RPS6KA1 25348397 N/A physical interaction ComPPI
PGD TXNDC5 25348397 N/A physical interaction ComPPI
PGD WWOX 25348397 N/A physical interaction ComPPI
PGD MOV10 25348397 N/A physical interaction ComPPI
PGD NXF1 25348397 N/A physical interaction ComPPI
PGD FABP5P3 25348397 N/A physical interaction ComPPI
PGD FABP5 25348397 N/A physical interaction ComPPI
PGD P4HB 25348397 N/A physical interaction ComPPI
PGD ACAA2 25348397 N/A physical interaction ComPPI
PGD CDV3 25348397 N/A physical interaction ComPPI
PGD EZR 25348397 N/A physical interaction ComPPI
PGD ISYNA1 25348397 N/A physical interaction ComPPI
PGD MSN 25348397 N/A physical interaction ComPPI
PGD NCBP1 25348397 N/A physical interaction ComPPI
PGD RDX 25348397 N/A physical interaction ComPPI
PGD SUMO2 25348397 N/A physical interaction ComPPI
PGD TAGLN 25348397 N/A physical interaction ComPPI
PGD UCHL3 25348397 N/A physical interaction ComPPI
PGD SUMO3 25348397 N/A physical interaction ComPPI
PGD TALDO1 25348397 N/A physical interaction ComPPI
PGD CEP290 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGD OFD1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PGD BRCA1 25348397 N/A physical interaction ComPPI
PGD ARF6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PGD HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PGD PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PGD IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PGD MYC 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PGD BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
PGD KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
PGD PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGB2 PGD 25348397 N/A physical interaction ComPPI
GDI1 PGD 25348397 N/A physical interaction ComPPI
YWHAQ PGD 25348397 N/A physical interaction ComPPI
SMARCB1 PGD 24234451 30108113 association proximity-dependent biotin identification IntAct
ISG15 PGD 16009940 27898060 N/A N/A OmniPath

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