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GENE：FLT3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FLT3
FullNmae fms related receptor tyrosine kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3765
EnsembleID ENSG00000122025
Uniprot P36888

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FLT3 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FLT3 GO:0001776,GO:0002318,GO:0002328,GO:0004713,GO:0004714,GO:0004714,GO:0004896,GO:0005021,GO:0005515,GO:0005524,GO:0005783,GO:0005788,GO:0005886,GO:0007169,GO:0007275,GO:0008284,GO:0010008,GO:0010243,GO:0018108,GO:0019221,GO:0019221,GO:0019221,GO:0019838,GO:0030097,GO:0030183,GO:0030183,GO:0031100,GO:0033674,GO:0035259,GO:0035726,GO:0038084,GO:0042531,GO:0042981,GO:0043235,GO:0043406,GO:0043410,GO:0043552,GO:0043621,GO:0044877,GO:0046651,GO:0046777,GO:0051897,GO:0071345,GO:0071345,GO:0071385,GO:0097028

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FLT3 hsa:2322 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
FLT3 hsa:2322 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
FLT3 hsa:2322 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
FLT3 hsa:2322 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
FLT3 hsa:2322 path:hsa05200 Pathways in cancer - Homo sapiens (human)
FLT3 hsa:2322 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
FLT3 hsa:2322 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
FLT3 hsa:2322 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FLT3LG FLT3 10477595 14670306 15253381 15749884 16418395 16713974 17404308 20547845 25215878 26192618 8920882 9268501 interaction type N/A ACSN
FLT3 STAT3 10477595 14670306 15253381 16418395 25215878 26192618 8920882 9268501 interaction type N/A ACSN
CD14 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
TIRAP FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
SPI1 FLT3 10734131 11672593 11964313 12032143 12803886 12811837 16283355 16418395 20510871 26192618 interaction type N/A ACSN
FLT3 PIK3R1 23180781 9918857 physical association anti tag coimmunoprecipitation InnateDB
FLT3 INPP5D 23180781 9918857 physical association anti tag coimmunoprecipitation InnateDB
FLT3 IKBKB 18670883 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG FLT3 20098747 23180781 physical association protein array InnateDB
CSK FLT3 23707526 interaction type,stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GRB2 FLT3 20005715 interaction type N/A PSP,SignaLink
NCK1 FLT3 10409713 18988627 20005715 interaction type N/A PSP,SignaLink
SH3BP2 FLT3 10409713 18988627 20005715 interaction type N/A PSP,SignaLink
SOCS1 FLT3 20005715 interaction type N/A PSP
SOCS1 FLT3 10022833 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SMARCA4 FLT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FLT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FLT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FLT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FLT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FLT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FLT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 FLT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PML FLT3 17124055 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 FLT3 16418395 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FLT3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000016FD1A FLT3 23079661 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000016FD1A FLT3 23079661 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000237AF9 FLT3 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
FLT3 FLT3 22135298 phosphorylation N/A PhosphoSite
FLT3 PDK1 22135298 phosphorylation N/A PhosphoSite
FIZ1 FLT3 25361965 interaction type N/A PTMCode2
FLT3 FIZ1 25361965 interaction type N/A PTMCode2
FLT3 HSP90AA1 25361965 interaction type N/A PTMCode2
HSP90AA1 FLT3 25361965 interaction type N/A PTMCode2
FLT3 GRB2 25361965 interaction type N/A PTMCode2
GRB2 FLT3 25361965 interaction type N/A PTMCode2
FLT3 PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 FLT3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PTPN6 FLT3 14525934 15831474 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CBL FLT3 25348397 N/A physical interaction ComPPI
SYK FLT3 24234451 24525236 25348397 27898060 28086240 phosphorylation reaction,colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,protein array,protein kinase assay,confocal microscopy ComPPI,IntAct,OmniPath
SLA FLT3 23300935 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SH3BP2 FLT3 10409713 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SOCS1 FLT3 10022833 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CBLB FLT3 14525934 25348397 9614102 N/A experimental interaction detection,in vivo ComPPI,HPRD
PIK3R1 FLT3 16982329 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN11 FLT3 16684964 24234451 25348397 27898060 association coimmunoprecipitation,competition binding ComPPI,IntAct,OmniPath
GRB10 FLT3 23246379 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct
INPP5D FLT3 14525934 25348397 9918857 N/A experimental interaction detection,in vivo ComPPI,HPRD
NCK1 FLT3 10409713 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
GRB2 FLT3 10080542 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SIAH1 FLT3 25348397 N/A physical interaction ComPPI
HSP90AA1 FLT3 25348397 N/A physical interaction ComPPI
SOCS2 FLT3 25348397 N/A physical interaction ComPPI
PTPN12 FLT3 14525934 15831474 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FLT3LG FLT3 14525934 25348397 7505204 9651358 N/A experimental interaction detection,in vivo ComPPI,HPRD
FLT3 FIZ1 10409713 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
FLT3 HSP90AA2P 25348397 N/A physical interaction ComPPI
FLT3 IKBKG 20098747 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
FLT3 UBE2L6 25348397 N/A physical interaction ComPPI
FLT3 FBXL13 25348397 N/A physical interaction ComPPI
FLT3 PTPRJ 23650535 24234451 25348397 27898060 physical association proximity ligation assay ComPPI,IntAct,OmniPath
FLT3 FLT3 11971190 14525934 N/A experimental interaction detection HPRD
ABL2 FLT3 24234451 28086240 physical association anti tag coimmunoprecipitation,protein array IntAct
CRKL FLT3 24234451 28086240 N/A protein array IntAct
YES1 FLT3 24234451 28086240 N/A protein array IntAct
CRK FLT3 24234451 28086240 N/A protein array IntAct
FYN FLT3 24234451 28086240 N/A protein array IntAct
ABL1 FLT3 24234451 28086240 N/A protein array IntAct
LCK FLT3 24234451 28086240 N/A protein array IntAct
SOCS6 FLT3 22952242 24234451 27898060 28086240 N/A protein array IntAct,OmniPath
RASA1 FLT3 24234451 28086240 N/A protein array IntAct
BLK FLT3 24234451 28086240 N/A protein array IntAct
FLT3 TNS1 24234451 28086240 N/A protein array IntAct
MRPS28 FLT3 24234451 30021884 physical association cross-linking study IntAct
IKBKG FLT3 20098747 27898060 N/A N/A OmniPath
FLT3LG FLT3 10080542 12681969 15147956 27898060 7505204 9651358 stimulant N/A OmniPath
FLT3 SHC1 10482988 10764799 10816433 10896916 10921922 11075717 12237775 16497976 17016520 17389395 18452278 18578522 18669648 19651622 19664994 19901323 20068231 20230923 27898060 9096689 9121430 9388490 9446569 9710204 9741627 N/A N/A OmniPath
PIK3R1 FLT3 16982329 27898060 9918857 N/A N/A OmniPath
FLT3 PIK3R1 16982329 27898060 9918857 stimulant N/A OmniPath
IKBKB FLT3 18670883 27898060 N/A N/A OmniPath

Visualization










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