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GENE：ACSL4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACSL4
FullNmae acyl-CoA synthetase long chain family member 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3571
EnsembleID ENSG00000068366
Uniprot O60488

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACSL4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACSL4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACSL4 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ACSL4 GO:0001676,GO:0001676,GO:0001676,GO:0004467,GO:0004467,GO:0004467,GO:0005524,GO:0005737,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005811,GO:0005811,GO:0005886,GO:0006629,GO:0006631,GO:0016020,GO:0030182,GO:0031957,GO:0032024,GO:0035336,GO:0035338,GO:0044233,GO:0047676,GO:0047676,GO:0060136,GO:0070062,GO:0090433

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACSL4 hsa:2182 path:hsa00061 Fatty acid biosynthesis - Homo sapiens (human)
ACSL4 hsa:2182 path:hsa00071 Fatty acid degradation - Homo sapiens (human)
ACSL4 hsa:2182 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ACSL4 hsa:2182 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)
ACSL4 hsa:2182 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)
ACSL4 hsa:2182 path:hsa04146 Peroxisome - Homo sapiens (human)
ACSL4 hsa:2182 path:hsa04216 Ferroptosis - Homo sapiens (human)
ACSL4 hsa:2182 path:hsa04714 Thermogenesis - Homo sapiens (human)
ACSL4 hsa:2182 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP ACSL4 21832049 23180781 physical association protein array InnateDB
ACSL4 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ACSL4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 ACSL4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ACSL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACSL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACSL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACSL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ACSL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACSL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ACSL4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 ACSL4 21566225 rna interference,inhibition experimental interaction detection miRSponge
URS00000ED600 ACSL4 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 ACSL4 21566225 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS0000065D58 ACSL4 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000451A1 ACSL4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000016914 ACSL4 24576478 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000012A1DD ACSL4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 ACSL4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 ACSL4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00005E6F45 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00004719AB ACSL4 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00002075FA ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000042E1F ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00000DDD35 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000039E1E1 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00000600E6 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00002B3783 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000037D7E5 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00003883FE ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000298BA3 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000012930C ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00001E0AEA ACSL4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 ACSL4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB ACSL4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002A71AD ACSL4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00000CBE63 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00004BCD9C ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00002233F4 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00003A5E54 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000076B539 ACSL4 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00001AFC71 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000028BB8 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000021D7C8 ACSL4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000251D0B ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00002C0FCB ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000315338 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00001C11BC ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000031602A ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000006FDD4 ACSL4 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 ACSL4 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00000C0D3F ACSL4 25416803 25961460 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SH3GLB1 ACSL4 25348397 N/A physical interaction ComPPI
KEAP1 ACSL4 25348397 N/A physical interaction ComPPI
NDUFAF4 ACSL4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SPART ACSL4 19765186 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAZ ACSL4 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
CFTR ACSL4 25348397 N/A physical interaction ComPPI
RAB5A ACSL4 25348397 N/A physical interaction ComPPI
YWHAQ ACSL4 25348397 N/A physical interaction ComPPI
TUBGCP3 ACSL4 25348397 N/A physical interaction ComPPI
BRF1 ACSL4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MME ACSL4 25348397 N/A physical interaction ComPPI
PRKN ACSL4 25348397 N/A physical interaction ComPPI
ELAVL1 ACSL4 25348397 N/A physical interaction ComPPI
TJAP1 ACSL4 25348397 N/A physical interaction ComPPI
HNRNPD ACSL4 25348397 N/A physical interaction ComPPI
HECW2 ACSL4 25348397 N/A physical interaction ComPPI
FOXL2 ACSL4 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ABCG1 ACSL4 25348397 N/A physical interaction ComPPI
EDEM1 ACSL4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NMT1 ACSL4 25348397 N/A physical interaction ComPPI
ATP6V0D1 ACSL4 25348397 N/A physical interaction ComPPI
EID3 ACSL4 25348397 N/A physical interaction ComPPI
HTATIP2 ACSL4 25348397 N/A physical interaction ComPPI
COQ9 ACSL4 25348397 N/A physical interaction ComPPI
TOR1AIP2 ACSL4 25348397 N/A physical interaction ComPPI
UVRAG ACSL4 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FOXA3 ACSL4 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
APP ACSL4 25348397 N/A physical interaction ComPPI
TP53 ACSL4 25348397 N/A physical interaction ComPPI
SLC1A5 ACSL4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX6B1 ACSL4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TOR1AIP2 ACSL4 25348397 N/A physical interaction ComPPI
STING1 ACSL4 22911572 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
MRPS15 ACSL4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACSL4 MICOS10 25348397 N/A physical interaction ComPPI
ACSL4 ACSL3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACSL4 DSE 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ACSL4 GNAT2 25348397 N/A physical interaction ComPPI
ACSL4 TBC1D22A 25348397 N/A physical interaction ComPPI
ACSL4 FOXI2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ACSL4 FOXJ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ACSL4 FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ACSL4 NDUFA4 25348397 N/A physical interaction ComPPI
ACSL4 PTPMT1 25348397 N/A physical interaction ComPPI
ACSL4 NMES1 25348397 N/A physical interaction ComPPI
ACSL4 MTMR14 25348397 N/A physical interaction ComPPI
ACSL4 SLC6A15 25348397 N/A physical interaction ComPPI
ACSL4 SLC15A1 25348397 N/A physical interaction ComPPI
ACSL4 SLC39A12 25348397 N/A physical interaction ComPPI
ACSL4 MICOS13 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ACSL4 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
H2BC9 ACSL4 24234451 30021884 physical association cross-linking study IntAct

Visualization










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