GENE：LPCAT3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LPCAT3 |
| FullNmae | lysophosphatidylcholine acyltransferase 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:30244 |
| EnsembleID | ENSG00000111684 |
| Uniprot | Q6P1A2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LPCAT3 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LPCAT3 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LPCAT3 | GO:0003841,GO:0005789,GO:0005789,GO:0006656,GO:0016020,GO:0016020,GO:0030258,GO:0034378,GO:0034379,GO:0036150,GO:0036150,GO:0036150,GO:0036151,GO:0036151,GO:0036151,GO:0036151,GO:0036152,GO:0036152,GO:0036152,GO:0036335,GO:0045540,GO:0045797,GO:0047144,GO:0047184,GO:0047184,GO:0047184,GO:0050728,GO:0071617,GO:0090158,GO:0106262,GO:0106262,GO:0106263,GO:1903573,GO:1905885 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LPCAT3 | hsa:10162 | path:hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| LPCAT3 | hsa:10162 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | LPCAT3 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | LPCAT3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | LPCAT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LPCAT3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000122ED0 | LPCAT3 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000324096 | LPCAT3 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00000D0BB4 | LPCAT3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BD6DC | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009EA8F | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000014F13C | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000ECE9C | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004E02F2 | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004BACE | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001A7A | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002394F5 | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000259AE4 | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00006097A6 | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002367FA | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AE8D3 | LPCAT3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005FDE70 | LPCAT3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000036AFF1 | LPCAT3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | LPCAT3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170D8B | LPCAT3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | LPCAT3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040828B | LPCAT3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| OPRM1 | LPCAT3 | 25348397 | N/A | physical interaction | ComPPI |
| VTN | LPCAT3 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | LPCAT3 | 25348397 | N/A | physical interaction | ComPPI |
| HTR2C | LPCAT3 | 25348397 | N/A | physical interaction | ComPPI |
| CHRM4 | LPCAT3 | 25348397 | N/A | physical interaction | ComPPI |
| C3AR1 | LPCAT3 | 25348397 | N/A | physical interaction | ComPPI |
| TACR1 | LPCAT3 | 25348397 | N/A | physical interaction | ComPPI |
| LPAR1 | LPCAT3 | 25348397 | N/A | physical interaction | ComPPI |