GENE:NRAS
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NRAS |
| FullNmae | NRAS proto-oncogene, GTPase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7989 |
| EnsembleID | ENSG00000213281 |
| Uniprot | P01111 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NRAS | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NRAS | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NRAS | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NRAS | apoptosis | 29437705 | Here, we report that coinhibition of NRAS or MEK plus PI3Kalpha triggers widespread apoptosis in NRAS-mutated RMS cells. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NRAS | GO:0000139,GO:0000165,GO:0001938,GO:0003924,GO:0003924,GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0005886,GO:0007265,GO:0007265,GO:0016020,GO:0019003,GO:0044877,GO:0045445,GO:0070062,GO:0070821 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NRAS | hsa:4893 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04540 | Gap junction - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04720 | Long-term potentiation - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04730 | Long-term depression - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04929 | GnRH secretion - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05034 | Alcoholism - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05213 | Endometrial cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05214 | Glioma - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05216 | Thyroid cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05219 | Bladder cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05224 | Breast cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05226 | Gastric cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
| NRAS | hsa:4893 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | NRAS | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | NRAS | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| MYC | NRAS | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | NRAS | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| E2F4 | NRAS | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AR | NRAS | 16281084 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | NRAS | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | NRAS | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYB | NRAS | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000324096 | NRAS | 17699775 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000031E12 | NRAS | 15766527 | rna interference,inhibition | array technology,western blot,northern blot,quantitative reverse transcription pcr | miRSponge |
| URS00004F4657 | NRAS | 23201159 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS0000521626 | NRAS | 23238785 | rna interference,inhibition | western blot | miRSponge |
| URS0000042E1F | NRAS | 19110058 | rna interference,inhibition | western blot | miRSponge |
| URS0000324096 | NRAS | 17699775 18668040 19966857 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000042E1F | NRAS | 19110058 25416803 | mrna cleavage,inhibition | western blot | TarBase |
| URS0000031E12 | NRAS | 15766527 25416803 | mrna cleavage,inhibition | array technology,western blot,northern blot,quantitative reverse transcription pcr | TarBase |
| URS00004F4657 | NRAS | 22592534 23201159 25416803 28332309 | mrna cleavage,inhibition | experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000521626 | NRAS | 23233531 23238785 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000122ED0 | NRAS | 19088304 25416803 26244871 27042128 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000070B1D | NRAS | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000160683 | NRAS | 24811402 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000037D7E5 | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003883FE | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001383CF | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ECFE5 | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000939AF | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019F055 | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000411752 | NRAS | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | NRAS | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | NRAS | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000358C16 | NRAS | 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000330617 | NRAS | 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B341F | NRAS | 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ACA7C | NRAS | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | NRAS | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A25B | NRAS | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032FC1A | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000610EFA | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000059EB31 | NRAS | 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000527B00 | NRAS | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | NRAS | 20371350 22473208 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | NRAS | 20371350 22473208 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | NRAS | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | NRAS | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E6EFA | NRAS | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000453664 | NRAS | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000E7139 | NRAS | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000048BA36 | NRAS | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004203C | NRAS | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRC | NRAS | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FBP2 | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| RABGGTB | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| SMAD4 | NRAS | 14525934 15761153 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| RASSF5 | NRAS | 14525934 25348397 9488663 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| RIN1 | NRAS | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SMURF2 | NRAS | 14525934 15761153 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SMAD1 | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| RACGAP1 | NRAS | 10655059 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CD2AP | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| GRB10 | NRAS | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| PIK3CG | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| RAP1GDS1 | NRAS | 11948427 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| THRB | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| PIK3CA | NRAS | 14525934 25348397 7820549 8665852 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| GRB14 | NRAS | 19648926 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PPP2CB | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| EEF1A1 | NRAS | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| RGL2 | NRAS | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| XPA | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| SRI | NRAS | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PAPOLA | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| FANCC | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| RASA1 | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| RAF1 | NRAS | 14525934 18641128 20080631 21478863 24234451 25348397 9488663 | physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach | ComPPI,HPRD,IntAct |
| SHOC2 | NRAS | 10783161 14525934 25348397 9674433 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| RASGRP2 | NRAS | 25348397 | N/A | in vitro,in vivo | ComPPI |
| PLP1 | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| ALDOB | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| SLC4A8 | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| BCL2 | NRAS | 10490827 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CORO2A | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| RTN1 | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| MAP2K7 | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| MAPKAPK3 | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| ACVR1 | NRAS | 14525934 15761153 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ELAVL1 | NRAS | 25348397 | N/A | physical interaction | ComPPI |
| BRAF | NRAS | 21478863 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| DNAJB1 | NRAS | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| AKT1 | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| RPS20 | NRAS | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| STX17 | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| FRAT2 | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| FOXP4 | NRAS | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| TDRD7 | NRAS | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| PLCE1 | NRAS | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| NRAS | ARHGAP4 | 25348397 | N/A | in vitro | ComPPI |
| NRAS | AFDN | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | EEF1A1P5 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | RNASEH2B | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | VAT1 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | SPATS2 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | TMEM185A | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | ABHD5 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | SLC39A12 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | ADGRE5 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | PACC1 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | GJB7 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | BZW2 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | GPR141 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | SLC37A3 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | NF1 | 25348397 | N/A | physical interaction | ComPPI |
| NRAS | TRMO | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| NRAS | AOPEP | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| NRAS | CYLC2 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| NRAS | HEMGN | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| NRAS | CCDC180 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| NRAS | LEF1 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| NRAS | SFRP4 | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| NRAS | RGL3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SRC | NRAS | 25157176 27898060 | stimulant | N/A | OmniPath |
| NRAS | BRAF | 21779497 27898060 7935411 | stimulant | N/A | OmniPath |
| RAPGEF1 | NRAS | 27898060 7959692 | stimulant | N/A | OmniPath |
| SOS1 | NRAS | 11560935 21779497 27898060 7923364 8493579 9690470 | stimulant | N/A | OmniPath |
| NRAS | PIK3CA | 21779497 27898060 7820549 8052307 8665852 9150145 | stimulant | N/A | OmniPath |
| RIN1 | NRAS | 11784866 12574403 27898060 | inhibition | N/A | OmniPath |
| NRAS | RAF1 | 10882715 18641128 20080631 21478863 21779497 27898060 7811320 8636091 8876196 9001246 9488663 9525741 9867809 | stimulant | N/A | OmniPath |
| NRAS | RALGDS | 27898060 7809086 | stimulant | N/A | OmniPath |
| NF1 | NRAS | 2116237 2121370 27898060 | inhibition | N/A | OmniPath |
| NRAS | ARAF | 21779497 27898060 | stimulant | N/A | OmniPath |
| ZDHHC9 | NRAS | 21779492 27898060 | stimulant | N/A | OmniPath |
| IQGAP1 | NRAS | 27898060 8670801 | inhibition | N/A | OmniPath |
| DAB2IP | NRAS | 27858941 27898060 | inhibition | N/A | OmniPath |
| RASGRP3 | NRAS | 10934204 27898060 2833817 9582122 | inhibition,stimulant | N/A | OmniPath |
| NRAS | PIK3CB | 21779497 27898060 | stimulant | N/A | OmniPath |
| NRAS | PIK3CG | 21779497 27898060 | stimulant | N/A | OmniPath |
| SYNGAP1 | NRAS | 27898060 9581761 | inhibition | N/A | OmniPath |
| RAP2A | NRAS | 10085114 27898060 | stimulant | N/A | OmniPath |
| RASGRF1 | NRAS | 11560935 1379346 27898060 7828890 9032266 9379834 9430727 | stimulant | N/A | OmniPath |
| RASA4 | NRAS | 11448776 12845332 27898060 | inhibition | N/A | OmniPath |
| RAPGEF6 | NRAS | 19201597 27898060 | stimulant | N/A | OmniPath |
| RASGEF1C | NRAS | 19201597 27898060 | stimulant | N/A | OmniPath |
| RAPGEF5 | NRAS | 19201597 27898060 | stimulant | N/A | OmniPath |
| RASGEF1A | NRAS | 19201597 27898060 | stimulant | N/A | OmniPath |
| RASGEF1B | NRAS | 19201597 27898060 | stimulant | N/A | OmniPath |
