Gene Information gene info

  1. Home

GENE：GLS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GLS2
FullNmae glutaminase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29570
EnsembleID ENSG00000135423
Uniprot Q9UI32

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GLS2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GLS2 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
GLS2 GO:0004359,GO:0005515,GO:0005739,GO:0005759,GO:0006520,GO:0006537,GO:0006543,GO:0042981,GO:0072593

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GLS2 hsa:27165 path:hsa00220 Arginine biosynthesis - Homo sapiens (human)
GLS2 hsa:27165 path:hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
GLS2 hsa:27165 path:hsa00470 D-Amino acid metabolism - Homo sapiens (human)
GLS2 hsa:27165 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GLS2 hsa:27165 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
GLS2 hsa:27165 path:hsa04727 GABAergic synapse - Homo sapiens (human)
GLS2 hsa:27165 path:hsa04964 Proximal tubule bicarbonate reclamation - Homo sapiens (human)
GLS2 hsa:27165 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
GLS2 hsa:27165 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YBX1 GLS2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GLS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GLS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GLS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GLS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GLS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GLS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 GLS2 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
TAX1BP3 GLS2 11163757 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
DLG4 GLS2 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PAG1 GLS2 11163757 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DLG2 GLS2 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RALA GLS2 25348397 N/A physical interaction ComPPI
CASK GLS2 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DLG1 GLS2 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DLG3 GLS2 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SNTA1 GLS2 11163757 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RGS3 GLS2 14525934 16637659 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
XAF1 GLS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GLS2 PATJ 25348397 N/A in vitro ComPPI
GLS2 GRHPR 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GLS2 HIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNTA1 GLS2 11163757 27898060 N/A N/A OmniPath
TP53 GLS2 16584535 27898060 N/A N/A OmniPath
TAX1BP3 GLS2 11163757 27898060 N/A N/A OmniPath

Visualization










  Return