GENE：GOT1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GOT1 |
| FullNmae | glutamic-oxaloacetic transaminase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4432 |
| EnsembleID | ENSG00000120053 |
| Uniprot | P17174 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GOT1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GOT1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GOT1 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GOT1 | GO:0004069,GO:0004069,GO:0004069,GO:0004609,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0006094,GO:0006103,GO:0006107,GO:0006114,GO:0006531,GO:0006532,GO:0006533,GO:0006536,GO:0007219,GO:0019550,GO:0019551,GO:0030170,GO:0032869,GO:0047801,GO:0051384,GO:0055089,GO:0070062 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GOT1 | hsa:2805 | path:hsa00220 | Arginine biosynthesis - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa00250 | Alanine, aspartate and glutamate metabolism - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa00270 | Cysteine and methionine metabolism - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa00330 | Arginine and proline metabolism - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa00350 | Tyrosine metabolism - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa00360 | Phenylalanine metabolism - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa00400 | Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa01200 | Carbon metabolism - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa01210 | 2-Oxocarboxylic acid metabolism - Homo sapiens (human) |
| GOT1 | hsa:2805 | path:hsa01230 | Biosynthesis of amino acids - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | GOT1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| E2F4 | GOT1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | GOT1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | GOT1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | GOT1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | GOT1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYB | GOT1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | GOT1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARA | GOT1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00004E008F | GOT1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005F305A | GOT1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004C689A | GOT1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000016914 | GOT1 | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003575B | GOT1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | GOT1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000236310 | GOT1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018C928 | GOT1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012A1DD | GOT1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171525 | GOT1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000055BBE5 | GOT1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000101787 | GOT1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00004283FE | GOT1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | GOT1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CHRAC1 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| PITPNA | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| PIR | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| NME1 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| TNIK | GOT1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| TPI1 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| ANXA11 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| EGFR | GOT1 | 20029029 24234451 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| HTRA2 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| WDR1 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| RAE1 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| PDCD6IP | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| UBE2H | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| SOD1 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| CCS | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| OAT | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| KIF2C | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| ABI3BP | GOT1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| SHMT2 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| YKT6 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| PC | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| NME2 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| NQO1 | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| PHGDH | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | ANXA6 | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | MTAP | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | SBDS | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | ACP1 | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | ALDH4A1 | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | FH | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | GPT2 | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | PITPNB | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | RFK | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | SRXN1 | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | UFM1 | 25348397 | N/A | physical interaction | ComPPI |
| GOT1 | HLA-B | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| TYMS | GOT1 | 25348397 | N/A | physical interaction | ComPPI |
| AGTR1 | GOT1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| CCR2 | GOT1 | 24234451 28298427 | physical association | ubiquitin reconstruction | IntAct |
| DAG1 | GOT1 | 24234451 | association | cross-linking study | IntAct |
| RPL6 | GOT1 | 24234451 30021884 | physical association | cross-linking study | IntAct |