Gene Information gene info

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GENE：CARS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CARS1
FullNmae cysteinyl-tRNA synthetase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1493
EnsembleID ENSG00000110619
Uniprot P49589

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CARS1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CARS1 GO:0000049,GO:0000049,GO:0004817,GO:0004817,GO:0004817,GO:0005515,GO:0005524,GO:0005524,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006423,GO:0006423,GO:0042802,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CARS1 hsa:833 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 CARS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 CARS1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA CARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 CARS1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000013DD8 CARS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000065D58 CARS1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PACSIN3 CARS1 25348397 N/A physical interaction ComPPI
TRAF6 CARS1 25348397 N/A physical interaction ComPPI
PACSIN1 CARS1 25348397 N/A physical interaction ComPPI
H4C1 CARS1 25348397 N/A physical interaction ComPPI
SFPQ CARS1 25348397 N/A physical interaction ComPPI
NTRK1 CARS1 25348397 N/A physical interaction ComPPI
FAF1 CARS1 25348397 N/A physical interaction ComPPI
EEF1A1 CARS1 25348397 N/A physical interaction ComPPI
ABTB1 CARS1 25348397 N/A physical interaction ComPPI
PAWR CARS1 25348397 N/A physical interaction ComPPI
TNF CARS1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SUMO2 CARS1 25348397 N/A physical interaction ComPPI
PSTPIP1 CARS1 25348397 N/A physical interaction ComPPI
HSPA4 CARS1 25348397 N/A physical interaction ComPPI
TTC1 CARS1 25348397 N/A physical interaction ComPPI
DNM1L CARS1 25348397 N/A physical interaction ComPPI
CAND1 CARS1 25348397 N/A physical interaction ComPPI
HIRIP3 CARS1 25348397 N/A physical interaction ComPPI
TRIM25 CARS1 25348397 N/A physical interaction ComPPI
KARS1 CARS1 25348397 N/A physical interaction ComPPI
LITAF CARS1 25348397 N/A physical interaction ComPPI
MLLT6 CARS1 25348397 N/A physical interaction ComPPI
XPO7 CARS1 25348397 N/A physical interaction ComPPI
EEF1G CARS1 10908348 14525934 25348397 26186194 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
EEF1D CARS1 25348397 N/A physical interaction ComPPI
LUC7L2 CARS1 25348397 N/A physical interaction ComPPI
PACSIN2 CARS1 25348397 N/A physical interaction ComPPI
APEH CARS1 25348397 N/A physical interaction ComPPI
EEF1A2 CARS1 25348397 N/A physical interaction ComPPI
HNRNPA1 CARS1 25348397 N/A physical interaction ComPPI
CBS CARS1 25348397 N/A physical interaction ComPPI
BATF3 CARS1 25348397 N/A physical interaction ComPPI
IDE CARS1 25348397 N/A physical interaction ComPPI
GFPT1 CARS1 25348397 N/A physical interaction ComPPI
APP CARS1 25348397 N/A physical interaction ComPPI
CARS1 JMJD6 25348397 N/A physical interaction ComPPI
CARS1 PPM1G 25348397 N/A physical interaction ComPPI
CARS1 SBDS 25348397 N/A physical interaction ComPPI

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