Gene Information gene info

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GENE：ATG7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATG7
FullNmae autophagy related 7
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16935
EnsembleID ENSG00000197548
Uniprot O95352

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATG7 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATG7 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATG7 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ATG7 entotic_cd 22002674 LC3 (Light chain 3) a component of autophagosomes, is recruited to single-membrane entotic vacuoles, macropinosomes and phagosomes harbouring apoptotic cells, in a manner dependent on the lipidation machinery including ATG5 and ATG7, and the class III phosphatidylinositol-3-kinase VPS34. retulator signature
ATG7 entotic_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ATG7 autophagy 36576150 However, little is known about the posttranslational modifications of ATG7, the essential protein in the autophagy process. retulator signature
ATG7 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ATG7 GO:0000045,GO:0000045,GO:0000407,GO:0000422,GO:0000422,GO:0005515,GO:0005576,GO:0005737,GO:0005737,GO:0005829,GO:0005930,GO:0006497,GO:0006501,GO:0006914,GO:0006914,GO:0006914,GO:0006995,GO:0009267,GO:0015031,GO:0016236,GO:0019778,GO:0019778,GO:0019778,GO:0019779,GO:0031401,GO:0032446,GO:0034727,GO:0034774,GO:0042752,GO:0042803,GO:0043065,GO:0044805,GO:0045732,GO:0048511,GO:0051607,GO:0071455,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATG7 hsa:10533 path:hsa04136 Autophagy - other - Homo sapiens (human)
ATG7 hsa:10533 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ATG7 hsa:10533 path:hsa04216 Ferroptosis - Homo sapiens (human)
ATG7 hsa:10533 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ATG7 ATG12 11096062 23180781 26192618 interaction type,physical association two hybrid ACSN,InnateDB
ATG7 ATG5 26192618 interaction type N/A ACSN
ATG7 ATG3 26192618 interaction type N/A ACSN
ATG7 ATG7 11096062 23180781 physical association cross-linking study InnateDB
ATG7 GABARAPL2 11096062 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG7 GABARAP 11096062 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 ATG7 19124466 23180781 physical association anti tag coimmunoprecipitation InnateDB
ATG7 SIRT1 18296641 23180781 physical association deacetylase assay InnateDB
IRF2 ATG7 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ATG7 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ATG7 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ATG7 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C ATG7 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR ATG7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HSF1 ATG7 23386620 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 ATG7 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS000016FF9C ATG7 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS00004AD450 ATG7 22291592 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000122F23 ATG7 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 ATG7 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS000008931A ATG7 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B ATG7 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00004DEA91 ATG7 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00005FDCD1 ATG7 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 ATG7 25416803 26313360 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS000055128B ATG7 25416803 26563733 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000039E1E1 ATG7 25416803 27981410 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ATG3 ATG7 25361965 interaction type N/A PTMCode2
ATG7 ATG3 25361965 interaction type N/A PTMCode2
GABARAPL1 ATG7 25361965 interaction type N/A PTMCode2
ATG7 GABARAPL1 25361965 interaction type N/A PTMCode2
GABARAPL2 ATG7 25361965 interaction type N/A PTMCode2
ATG7 GABARAPL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TXLNB ATG7 25348397 N/A physical interaction ComPPI
BAG3 ATG7 25348397 N/A physical interaction ComPPI
STAT1 ATG7 25348397 N/A physical interaction ComPPI
GTF2A1 ATG7 25348397 N/A physical interaction ComPPI
GABARAPL2 ATG7 11890701 14525934 16303767 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,comigration in non denaturing gel electrophoresis,in vitro,in vivo ComPPI,HPRD,IntAct
MAP1LC3B ATG7 11890701 14525934 16303767 18083104 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,comigration in non denaturing gel electrophoresis,in vitro,in vivo ComPPI,HPRD,IntAct
KHDRBS2 ATG7 25348397 N/A physical interaction ComPPI
EP300 ATG7 25348397 N/A physical interaction ComPPI
NTRK1 ATG7 25348397 N/A physical interaction ComPPI
SNX1 ATG7 25348397 N/A physical interaction ComPPI
SNX2 ATG7 25348397 N/A physical interaction ComPPI
SNX6 ATG7 25348397 N/A physical interaction ComPPI
TRIP6 ATG7 25348397 N/A physical interaction ComPPI
PPP2CB ATG7 25348397 N/A physical interaction ComPPI
HNRNPL ATG7 25348397 N/A physical interaction ComPPI
SQSTM1 ATG7 25348397 N/A physical interaction ComPPI
RDX ATG7 25348397 N/A physical interaction ComPPI
UBA6 ATG7 25348397 N/A physical interaction ComPPI
TBCD ATG7 25348397 N/A physical interaction ComPPI
MAN2B1 ATG7 25348397 N/A physical interaction ComPPI
STXBP6 ATG7 25348397 N/A physical interaction ComPPI
CTTN ATG7 25348397 N/A physical interaction ComPPI
GABARAP ATG7 11890701 14525934 16303767 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,comigration in non denaturing gel electrophoresis,in vitro,in vivo ComPPI,HPRD,IntAct
MAP1LC3A ATG7 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT1 ATG7 18296641 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,deacetylase assay ComPPI,IntAct
RIPK1 ATG7 25348397 N/A physical interaction ComPPI
GSPT2 ATG7 25348397 N/A physical interaction ComPPI
TRIM25 ATG7 25348397 N/A physical interaction ComPPI
GFER ATG7 25348397 N/A physical interaction ComPPI
MAT2B ATG7 25348397 N/A physical interaction ComPPI
KCNJ5 ATG7 25348397 N/A physical interaction ComPPI
PPP3CB ATG7 25348397 N/A physical interaction ComPPI
UBA3 ATG7 25348397 N/A physical interaction ComPPI
NASP ATG7 25348397 N/A physical interaction ComPPI
EEF1D ATG7 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
IRF2 ATG7 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG3 ATG7 11825910 14525934 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
ATG7 ATG12 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,in vivo ComPPI,IntAct
ATG7 ATG10 12482611 14525934 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ATG7 MAP1LC3C 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG7 GABARAPL1 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ATG7 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG7 PIK3C2A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATG7 FOXO1 25348397 N/A physical interaction ComPPI
ATG7 APP 25348397 N/A physical interaction ComPPI
ATG7 ANP32E 25348397 N/A physical interaction ComPPI
ATG7 VPS36 25348397 N/A physical interaction ComPPI
ATG7 DNAAF10 25348397 N/A physical interaction ComPPI
ATG7 GSPT1 25348397 N/A physical interaction ComPPI
ATG7 SARS1 25348397 N/A physical interaction ComPPI
ATG7 SHMT2 25348397 N/A physical interaction ComPPI
ATG7 UGDH 25348397 N/A physical interaction ComPPI
ATG7 KIAA0930 25348397 N/A physical interaction ComPPI
ATG7 UROS 25348397 N/A physical interaction ComPPI
ATG7 RWDD2A 25348397 N/A physical interaction ComPPI
ATG7 PSG1 25348397 N/A physical interaction ComPPI
ATG7 ARHGAP25 25348397 N/A physical interaction ComPPI
ATG7 ATP23 25348397 N/A physical interaction ComPPI
ATG7 NAA40 25348397 N/A physical interaction ComPPI
ATG7 MICU2 25348397 N/A physical interaction ComPPI
ATG7 DNLZ 25348397 N/A physical interaction ComPPI
ATG7 FKBP5 25348397 N/A physical interaction ComPPI
ATG7 TP53 22499945 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ATG7 SLX4 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
LGMN ATG7 25348397 N/A physical interaction ComPPI
ATP6V1C1 ATG7 25348397 N/A physical interaction ComPPI
ATG7 ATG7 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
ATG7 ATG3 11139573 11825910 12965207 17227760 17986448 20562859 22055190 22055191 22056771 22170151 22325599 23142976 24186333 24191030 27898060 stimulant N/A OmniPath
FOXO1 ATG7 20543840 22622204 23640897 27898060 stimulant N/A OmniPath
TP63 ATG7 22356768 27898060 N/A N/A OmniPath
ATG7 MAP1LC3B 11100732 11890701 15355958 16303767 20562859 22170151 24023838 27898060 stimulant N/A OmniPath
ATG7 ATG10 10508157 11096062 11890701 12482611 20562859 22056771 23142976 26186194 27898060 9759731 stimulant N/A OmniPath
HSF1 ATG7 23386620 27898060 N/A N/A OmniPath
ATG7 ATG12 10233150 11096062 11100732 11139573 11265251 11890701 12482611 12965207 18704115 20562859 27898060 9759731 stimulant N/A OmniPath
ATG7 EP300 19124466 27898060 N/A N/A OmniPath
ATG7 MAP1LC3A 11096062 16303767 20562859 22170151 27898060 stimulant N/A OmniPath
TP73 ATG7 19001857 27898060 N/A N/A OmniPath
ATG7 ATG5 11265251 27898060 stimulant N/A OmniPath

Visualization










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