GENE：NCOA4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NCOA4 |
| FullNmae | nuclear receptor coactivator 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7671 |
| EnsembleID | ENSG00000266412 |
| Uniprot | Q13772 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NCOA4 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| NCOA4 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| NCOA4 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NCOA4 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| NCOA4 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NCOA4 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NCOA4 | GO:0003713,GO:0005634,GO:0006622,GO:0006879,GO:0008584,GO:0009725,GO:0030520,GO:0044754,GO:0045893,GO:0071391,GO:0071394 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NCOA4 | hsa:8031 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
| NCOA4 | hsa:8031 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| NCOA4 | hsa:8031 | path:hsa05216 | Thyroid cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ESR1 | NCOA4 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | NCOA4 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | NCOA4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | NCOA4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HIF1A | NCOA4 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| AR | NCOA4 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NCOA4 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARG | NCOA4 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000DDD35 | NCOA4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005651EE | NCOA4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000031B6ED | NCOA4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000075994C | NCOA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016E46F | NCOA4 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C28B2 | NCOA4 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004DA9DB | NCOA4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005D986D | NCOA4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000508C13 | NCOA4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | NCOA4 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000366551 | NCOA4 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000027352D | NCOA4 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002198F3 | NCOA4 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | NCOA4 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AEA5 | NCOA4 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GTF2B | NCOA4 | 25361965 | interaction type | N/A | PTMCode2 |
| NCOA4 | GTF2B | 25361965 | interaction type | N/A | PTMCode2 |
| NR3C1 | NCOA4 | 25361965 | interaction type | N/A | PTMCode2 |
| NCOA4 | NR3C1 | 25361965 | interaction type | N/A | PTMCode2 |
| AR | NCOA4 | 25361965 | interaction type | N/A | PTMCode2 |
| NCOA4 | AR | 25361965 | interaction type | N/A | PTMCode2 |
| NCOA4 | RXRA | 25361965 | interaction type | N/A | PTMCode2 |
| RXRA | NCOA4 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GMCL1 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| FTL | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| FTH1 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| PSMD14 | NCOA4 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| GTF2B | NCOA4 | 14525934 25348397 9892017 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| KDR | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| AR | NCOA4 | 10517667 11818501 12068007 14525934 15563469 24234451 25348397 8643607 9636157 9892017 | N/A | coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,biochemical,two hybrid | ComPPI,HPRD,IntAct |
| VDR | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| KAT2B | NCOA4 | 14525934 25348397 9892017 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| PPARG | NCOA4 | 10347167 14525934 25348397 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| GRIA2 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK6 | NCOA4 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| XPO1 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| HUWE1 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| TAX1BP1 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| HIF1AN | NCOA4 | 24234451 25348397 29426014 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| NR3C1 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| TFG | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| PSMC1 | NCOA4 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ATXN2 | NCOA4 | 14525934 16713569 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid | ComPPI,HPRD,IntAct |
| ESR1 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| AKT1 | NCOA4 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| XRCC3 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| KIFC3 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| NEURL4 | NCOA4 | 25348397 | N/A | physical interaction | ComPPI |
| HERC2 | NCOA4 | 24234451 25348397 29426014 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RXRA | NCOA4 | 10347167 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| NCOA4 | HERC2P3 | 25348397 | N/A | physical interaction | ComPPI |
| NCOA4 | KIF21A | 25348397 | N/A | physical interaction | ComPPI |
| NCOA4 | USP43 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NCOA4 | GMCL2 | 25348397 | N/A | physical interaction | ComPPI |
| RNF14 | NCOA4 | 10085091 14525934 | N/A | experimental interaction detection | HPRD |
| NCOA4 | AR | 10318905 10347167 10517667 11404460 11779876 11818501 12068007 12612084 15563469 15604093 27898060 8643607 9636157 9892017 | stimulant | N/A | OmniPath |
| NCOA4 | PPARG | 10347167 11877444 27898060 | stimulant | N/A | OmniPath |