GENE：ALOX12B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ALOX12B |
| FullNmae | arachidonate 12-lipoxygenase, 12R type |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:430 |
| EnsembleID | ENSG00000179477 |
| Uniprot | O75342 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ALOX12B | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ALOX12B | GO:0004052,GO:0004052,GO:0005506,GO:0005829,GO:0005829,GO:0006497,GO:0006665,GO:0010628,GO:0016702,GO:0016829,GO:0016853,GO:0019369,GO:0019369,GO:0019369,GO:0019372,GO:0019372,GO:0019372,GO:0034440,GO:0043231,GO:0043410,GO:0043651,GO:0043651,GO:0046513,GO:0047677,GO:0048471,GO:0048471,GO:0051122,GO:0051122,GO:0061436,GO:0070257,GO:0106237,GO:1990136 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ALOX12B | hsa:242 | path:hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| ALOX12B | hsa:242 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| ALOX12B | hsa:242 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | ALOX12B | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ALOX12B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ALOX12B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ALOX12B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ALOX12B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GMCL1 | ALOX12B | 25348397 | N/A | physical interaction | ComPPI |
| TBC1D22B | ALOX12B | 25348397 | N/A | physical interaction | ComPPI |
| GPANK1 | ALOX12B | 25348397 | N/A | physical interaction | ComPPI |
| KRT5 | ALOX12B | 10727209 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| FTH1 | ALOX12B | 25348397 | N/A | physical interaction | ComPPI |
| LMNA | ALOX12B | 25348397 | N/A | two hybrid,in vitro,in vivo | ComPPI |
| CFTR | ALOX12B | 25348397 | N/A | physical interaction | ComPPI |
| TGM1 | ALOX12B | 22622417 24234451 25348397 | physical association | proximity ligation assay | ComPPI,IntAct |
| NPPA | ALOX12B | 25348397 | N/A | physical interaction | ComPPI |
| NFKB1 | ALOX12B | 24234451 25348397 25609649 | association | tandem affinity purification | ComPPI,IntAct |
| AIRE | ALOX12B | 25348397 | N/A | physical interaction | ComPPI |
| CYLD | ALOX12B | 25348397 | N/A | physical interaction | ComPPI |
| ALOX12B | KIR3DS1 | 25348397 | N/A | physical interaction | ComPPI |
| ALOX12B | GMCL2 | 25348397 | N/A | physical interaction | ComPPI |