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GENE：ULK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ULK1
FullNmae unc-51 like autophagy activating kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12558
EnsembleID ENSG00000177169
Uniprot O75385

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ULK1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ULK1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ULK1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ULK1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ULK1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
UlK1 cuproptosis 38006800 As for CRG, 19 CRGs(CP,CD274,PDE3B,DLAT,VEGFA,DBH,COX11,COA6,PDK1,SLC31A2,UBE2D1,UlK1,SLC25A3,MTF1,UBE2D3,SLC31A1,MAP2K1,AOC3,CCL8) were significantly differentially expressed in the Control and sepsis induced cardiotoxicity groups in GSE44363 cuproptosis-related genes
ULK1 cuproptosis 38341588 At the same time, copper is also a dynamic signaling metal and metal allosteric regulator, such as copper-dependent phosphodiesterase 3B (PDE3B) in lipolysis, mitogen-activated protein kinase kinase 1 (MEK1) in cell growth and proliferation and MEK2, the kinases ULK1 and ULK2 in autophagy. Cell proliferation that relies on copper is called copper hyperplasia, which corresponds to this article about copper death. These enzymes may have some interactions with FDX1 signaling, which may be a focus of future research. interactions with FDX4
ULK1 cuproptosis 38348451 Unc-51-like autophagy activating kinases. Autophagy pathways can be influenced by copper and may play a role in cuproptosis. CRGs in the cuproptosis pathway
ULK1 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
ULK1 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
ULK1 cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
ULK1 GO:0000045,GO:0000045,GO:0000407,GO:0000407,GO:0000421,GO:0000422,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005737,GO:0005737,GO:0005737,GO:0005741,GO:0005776,GO:0005776,GO:0005789,GO:0005829,GO:0005829,GO:0005829,GO:0006468,GO:0006914,GO:0006914,GO:0006914,GO:0006914,GO:0007165,GO:0008104,GO:0008285,GO:0010508,GO:0010508,GO:0010508,GO:0010508,GO:0010803,GO:0016236,GO:0016236,GO:0016241,GO:0018105,GO:0018105,GO:0018107,GO:0030424,GO:0031102,GO:0031175,GO:0031267,GO:0031333,GO:0031669,GO:0034045,GO:0034045,GO:0034727,GO:0042594,GO:0042594,GO:0042802,GO:0044805,GO:0044877,GO:0046777,GO:0046777,GO:0048671,GO:0048675,GO:0051020,GO:0055037,GO:0061709,GO:0106310,GO:1903059,GO:1903349,GO:1990316,GO:2000786

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ULK1 hsa:8408 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
ULK1 hsa:8408 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ULK1 hsa:8408 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
ULK1 hsa:8408 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
ULK1 hsa:8408 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
ULK1 hsa:8408 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ULK1 hsa:8408 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
ULK1 hsa:8408 path:hsa05016 Huntington disease - Homo sapiens (human)
ULK1 hsa:8408 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ULK1 hsa:8408 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JUN ULK1 11001584 11274345 16054035 16396903 16406505 16880536 17000779 17439715 17638910 18754008 18813803 19081070 19190345 19219074 20107231 22354771 23031257 26192618 26587781 8545107 interaction type N/A ACSN
GLI1 ULK1 11001584 11960000 12138125 14555646 15087129 15520176 16054035 16158046 16328026 16396903 16406505 16571352 16880536 17000779 17035233 17638910 18754008 18813803 19081070 19190345 19219074 19736394 20107231 21059263 21442356 22354771 23031257 26192618 interaction type N/A ACSN
ULK1 RB1CC1 19211835 19225151 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
ULK1 ATG13 19211835 19225151 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
ATG13 ULK1 19225151 19287211 20562859 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,in-gel kinase assay InnateDB
ATG101 ULK1 19287211 19597335 23180781 physical association anti tag coimmunoprecipitation InnateDB
RB1CC1 ULK1 19225151 20562859 23180781 physical association anti tag coimmunoprecipitation InnateDB
ULK1 ULK1 19225151 23180781 phosphorylation reaction in-gel kinase assay InnateDB
ULK1 MTOR 19225151 23180781 phosphorylation reaction in-gel kinase assay InnateDB
ULK1 E2F1 18408756 23180781 physical association anti tag coimmunoprecipitation InnateDB
E2F4 ULK1 18408756 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 ULK1 23180781 24119841 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 ULK1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF ULK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ULK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ULK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ULK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ULK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ULK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ULK1 18408756 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ULK1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000BE495 ULK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD ULK1 21572407 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS000021D7C8 ULK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000042E1F ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00000DDD35 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000039E1E1 ULK1 21572407 25416803 27372519 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00001E0AEA ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00000600E6 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000070CD2 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000346991 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000027080C ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000041E949 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000508C13 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00002B3783 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000000E601 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000298BA3 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000568FF8 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS00003B6B84 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS0000004CA3 ULK1 21572407 25416803 mrna cleavage,inhibition clip,clip TarBase
URS000006F90B ULK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA ULK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 ULK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001DABC0 ULK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F ULK1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 ULK1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 ULK1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA1 ULK1 22135298 phosphorylation N/A PhosphoSite
ULK1 CDC37 22135298 phosphorylation N/A PhosphoSite
ULK1 RPTOR 22135298 phosphorylation N/A PhosphoSite
ULK1 ATG9A 22135298 phosphorylation N/A PhosphoSite
ULK1 FBP1 22135298 phosphorylation N/A PhosphoSite
ULK1 SMCR8 22135298 phosphorylation N/A PhosphoSite
ULK1 STING1 22135298 phosphorylation N/A PhosphoSite
ULK1 ATG13 22135298 phosphorylation N/A PhosphoSite
ULK1 PFKM 22135298 phosphorylation N/A PhosphoSite
ULK1 ENO1 22135298 phosphorylation N/A PhosphoSite
ULK1 HK1 22135298 phosphorylation N/A PhosphoSite
ULK1 SDCBP 22135298 phosphorylation N/A PhosphoSite
ULK1 SEC16A 22135298 phosphorylation N/A PhosphoSite
ULK1 DENND3 22135298 phosphorylation N/A PhosphoSite
MTOR ULK1 22135298 phosphorylation N/A PhosphoSite
RB1CC1 ULK1 25361965 interaction type N/A PTMCode2
ULK1 RB1CC1 25361965 interaction type N/A PTMCode2
GABARAPL2 ULK1 25361965 interaction type N/A PTMCode2
ULK1 GABARAPL2 25361965 interaction type N/A PTMCode2
ULK1 SYNGAP1 25361965 interaction type N/A PTMCode2
SYNGAP1 ULK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
WASHC3 ULK1 25348397 N/A physical interaction ComPPI
TRIM21 ULK1 25348397 N/A physical interaction ComPPI
PRKAA2 ULK1 20562859 21072212 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF6 ULK1 23524951 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GABARAPL2 ULK1 11146101 14525934 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
MAP1LC3B ULK1 20562859 24234451 24290141 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
EXOC8 ULK1 25348397 N/A physical interaction ComPPI
CBLB ULK1 24234451 25348397 26593251 association coimmunoprecipitation ComPPI,IntAct
OCLN ULK1 16616143 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FEZ1 ULK1 22354037 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NRBF2 ULK1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAA1 ULK1 20562859 21072212 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBB ULK1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI
UBC ULK1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI
RPS27A ULK1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI
UBA52 ULK1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI
NTRK1 ULK1 17389358 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRF3 ULK1 25348397 N/A physical interaction ComPPI
PDPK1 ULK1 24234451 25348397 26593251 physical association coimmunoprecipitation ComPPI,IntAct
PPP1CA ULK1 22321011 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SQSTM1 ULK1 17389358 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAPK3 ULK1 25348397 N/A physical interaction ComPPI
RAB1A ULK1 25348397 N/A physical interaction ComPPI
SDCBP ULK1 14525934 15014045 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EXOC2 ULK1 25348397 N/A physical interaction ComPPI
RALB ULK1 25348397 N/A physical interaction ComPPI
NEDD4L ULK1 25348397 N/A physical interaction ComPPI
HTT ULK1 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MBP ULK1 25348397 N/A physical interaction ComPPI
GABARAP ULK1 11146101 14525934 17353931 20562859 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MAP1LC3A ULK1 25348397 N/A pull down,physical interaction,physical interaction ComPPI
MEFV ULK1 25348397 N/A physical interaction ComPPI
SYNGAP1 ULK1 14525934 15014045 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CDC37 ULK1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BECN1 ULK1 25348397 N/A physical interaction ComPPI
TRIM25 ULK1 25348397 N/A physical interaction ComPPI
BIRC2 ULK1 25348397 N/A physical interaction ComPPI
RB1CC1 ULK1 20562859 23392225 23524951 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
MTOR ULK1 23524951 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MLST8 ULK1 25348397 N/A physical interaction ComPPI
ULK1 ATG4B 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 G3BP1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 USP10 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 PRKAG1 20562859 21072212 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 PRKAB2 25348397 N/A physical interaction ComPPI
ULK1 AMBRA1 23524951 24234451 25348397 25438055 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 RPTOR 24234451 25348397 25686248 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 ATG13 19597335 20562859 23392225 23524951 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
ULK1 MAP1LC3C 20562859 24234451 24290141 25348397 association,physical association pull down,physical interaction ComPPI,IntAct
ULK1 GABARAPL1 20562859 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
ULK1 ATG16L1 23392225 24234451 25348397 colocalization,association cross-linking study,physical interaction,fluorescence microscopy ComPPI,IntAct
ULK1 SESN2 24234451 25040165 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 ATG101 19597335 23392225 24234451 25348397 25686248 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
ULK1 NLRP3 25348397 N/A physical interaction ComPPI
ULK1 IRGM 25348397 N/A physical interaction ComPPI
ULK1 FLCN 25348397 N/A physical interaction ComPPI
ULK1 PRKAB1 21072212 24234451 25348397 25686248 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 TRIM16 25348397 N/A physical interaction ComPPI
ULK1 NIPSNAP2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ULK1 ATG5 23392225 24234451 25348397 association cross-linking study ComPPI,IntAct
ULK1 TBC1D14 22613832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,fluorescence microscopy ComPPI,IntAct
ULK1 ATG9A 22613832 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
ULK1 TBC1D5 24234451 24603492 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK1 ZFYVE1 24234451 25348397 28712572 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK1 PCM1 24234451 25348397 28712572 colocalization confocal microscopy ComPPI,IntAct
ULK1 C9ORF72 24234451 25348397 27334615 physical association proximity ligation assay ComPPI,IntAct
MUL1 ULK1 25348397 N/A physical interaction ComPPI
ULK1 ULK1 20562859 23524951 24234451 physical association anti tag coimmunoprecipitation IntAct
ULK1 PRKAA2 19584320 21205641 21460634 27898060 inhibition N/A OmniPath
PRKAA2 ULK1 19584320 21205641 21460634 27898060 stimulant N/A OmniPath
ULK1 GABARAP 11146101 17353931 20562859 22885598 23043107 25126726 27898060 stimulant N/A OmniPath
PRKAB1 ULK1 21460634 27898060 stimulant N/A OmniPath
ATG13 ULK1 18936157 19211835 19225151 19258318 19287211 19597335 20562859 21460630 23524951 25126726 25686248 26018823 27898060 stimulant N/A OmniPath
ULK1 ATG13 18936157 19211835 19225151 19258318 19287211 19597335 20562859 21460630 21855797 23524951 25126726 25686248 26018823 26138443 27898060 stimulant N/A OmniPath
TP63 ULK1 22356768 27898060 N/A N/A OmniPath
KAT5 ULK1 22539723 27898060 stimulant N/A OmniPath
ULK1 AMBRA1 20921139 23524951 27898060 stimulant N/A OmniPath
TP53 ULK1 21475306 27898060 N/A N/A OmniPath
E2F1 ULK1 18408756 27898060 N/A N/A OmniPath
ULK1 ATG101 19287211 19597335 25686248 27898060 N/A N/A OmniPath
ULK1 BECN1 16940348 17595159 21241894 23685627 25891078 27898060 stimulant N/A OmniPath
ULK1 RB1CC1 18443221 18981720 19211835 19225151 19258318 19597335 20562859 25686248 27898060 stimulant N/A OmniPath
RB1CC1 ULK1 18443221 18981720 19211835 19225151 19258318 20562859 25686248 27898060 stimulant N/A OmniPath
ULK1 DYNLL1 20921139 27898060 inhibition N/A OmniPath
ULK1 RPTOR 19864431 21325048 21460630 25686248 27898060 N/A N/A OmniPath
ULK1 MTOR 19225151 19690328 21460630 25686248 27898060 N/A N/A OmniPath
MTOR ULK1 10995454 17595159 19225151 19690328 21258367 21383122 21460630 21460634 25126726 25499913 25686248 27898060 inhibition N/A OmniPath
PRKAG1 ULK1 20562859 21383122 25686248 27898060 N/A N/A OmniPath
ULK1 DAPK3 21169990 27898060 stimulant N/A OmniPath
ATF4 ULK1 23078367 27898060 N/A N/A OmniPath
ULK1 STING1 24119841 26118643 27898060 N/A N/A OmniPath
ULK1 PRKAA1 20562859 21460634 25686248 27898060 inhibition N/A OmniPath
PRKAA1 ULK1 20562859 21460634 25686248 27898060 stimulant N/A OmniPath
ULK1 SDCBP 15014045 21949238 27898060 N/A N/A OmniPath
ZKSCAN3 ULK1 23434374 27898060 N/A N/A OmniPath
SMCR8 ULK1 27898060 28195531 inhibition N/A OmniPath
ULK1 PRKAG3 21460634 27898060 inhibition N/A OmniPath
ULK1 DENND3 25925668 27898060 N/A N/A OmniPath

Visualization










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