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GENE：SNX4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SNX4
FullNmae sorting nexin 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11175
EnsembleID ENSG00000114520
Uniprot O95219

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SNX4 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
SNX4 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
SNX4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SNX4 GO:0005154,GO:0005158,GO:0005515,GO:0005737,GO:0005769,GO:0005868,GO:0005886,GO:0005886,GO:0015031,GO:0015031,GO:0016020,GO:0031201,GO:0031201,GO:0031901,GO:0031901,GO:0032266,GO:0032266,GO:0032456,GO:0032991,GO:0035091,GO:0098830,GO:1903595,GO:1990459,GO:1990460,GO:2000786,GO:2000786

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SNX4 hsa:8723 path:hsa04144 Endocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SNX4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 SNX4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SNX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SNX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SNX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SNX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SNX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SNX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SNX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001F0C23 SNX4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000016D2D4 SNX4 20371350 21572407 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00001A405B SNX4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003003B4 SNX4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002A79D1 SNX4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A SNX4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000045E0EC SNX4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC SNX4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB SNX4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000005D4F5 SNX4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F SNX4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 SNX4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C SNX4 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 SNX4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000170CF4 SNX4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 SNX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 SNX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 SNX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C SNX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C SNX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF SNX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 SNX4 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SNX4 EGFR 25361965 interaction type N/A PTMCode2
EGFR SNX4 25361965 interaction type N/A PTMCode2
SNX4 LEPR 25361965 interaction type N/A PTMCode2
LEPR SNX4 25361965 interaction type N/A PTMCode2
SNX4 SNX6 25361965 interaction type N/A PTMCode2
SNX6 SNX4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SH3GLB1 SNX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAGEA6 SNX4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PDGFRB SNX4 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PDGFRA SNX4 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SNX2 SNX4 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SNX6 SNX4 11279102 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
LEPR SNX4 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PTPN5 SNX4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CACYBP SNX4 25348397 N/A physical interaction ComPPI
DCTN1 SNX4 23524952 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CFTR SNX4 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
WWC1 SNX4 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
BIN1 SNX4 12668730 14525934 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct,OmniPath
EGFR SNX4 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction ComPPI,HPRD
COPS6 SNX4 25348397 N/A physical interaction ComPPI
SUPT5H SNX4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HIVEP1 SNX4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BECN1 SNX4 22081109 24234451 25348397 physical association two hybrid ComPPI,IntAct
INSR SNX4 14525934 25348397 9819414 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ARL6IP1 SNX4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TGOLN2 SNX4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SNX7 SNX4 23085988 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SCLT1 SNX4 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SNX4 INTS2 25348397 N/A physical interaction ComPPI
SNX4 ATP6V0A1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SNX4 DUSP18 25348397 N/A physical interaction ComPPI
SNX4 SNX30 23085988 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SNX4 ANKMY2 25348397 N/A physical interaction ComPPI
SNX4 ABCB10 25348397 N/A physical interaction ComPPI
SNX4 DGAT2L6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNX4 AGK 14525934 16169070 N/A two hybrid HPRD
SNX4 SNX4 23085988 24234451 physical association pull down IntAct

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