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GENE：ULK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ULK2
FullNmae unc-51 like autophagy activating kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13480
EnsembleID ENSG00000083290
Uniprot Q8IYT8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ULK2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ULK2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ULK2 cuproptosis 38341588 At the same time, copper is also a dynamic signaling metal and metal allosteric regulator, such as copper-dependent phosphodiesterase 3B (PDE3B) in lipolysis, mitogen-activated protein kinase kinase 1 (MEK1) in cell growth and proliferation and MEK2, the kinases ULK1 and ULK2 in autophagy. Cell proliferation that relies on copper is called copper hyperplasia, which corresponds to this article about copper death. These enzymes may have some interactions with FDX1 signaling, which may be a focus of future research. interactions with FDX5
ULK2 cuproptosis 38348451 Unc-51-like autophagy activating kinases. Autophagy pathways can be influenced by copper and may play a role in cuproptosis. CRGs in the cuproptosis pathway
ULK2 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
ULK2 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
ULK2 GO:0000045,GO:0000407,GO:0000422,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005776,GO:0005829,GO:0006914,GO:0006914,GO:0007165,GO:0010508,GO:0018105,GO:0030659,GO:0034045,GO:0034045,GO:0034727,GO:0042594,GO:0042594,GO:0044805,GO:0046777,GO:0046777,GO:0048668,GO:0048671,GO:0048675,GO:0061709,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ULK2 hsa:9706 path:hsa04136 Autophagy - other - Homo sapiens (human)
ULK2 hsa:9706 path:hsa04140 Autophagy - animal - Homo sapiens (human)
ULK2 hsa:9706 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
ULK2 hsa:9706 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ULK2 hsa:9706 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
ULK2 hsa:9706 path:hsa05016 Huntington disease - Homo sapiens (human)
ULK2 hsa:9706 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ULK2 hsa:9706 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ULK2 SQSTM1 14702098 23180781 physical association pull down InnateDB
ULK2 ATG13 19225151 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,in-gel kinase assay InnateDB
RB1CC1 ULK2 19225151 23180781 physical association anti tag coimmunoprecipitation InnateDB
ULK2 RB1CC1 19225151 23180781 physical association pull down InnateDB
ULK2 ULK2 19225151 23180781 phosphorylation reaction in-gel kinase assay InnateDB
ULK2 MTOR 19225151 23180781 phosphorylation reaction in-gel kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 ULK2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 ULK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ULK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ULK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ULK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ULK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ULK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ULK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ULK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A ULK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ULK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ULK2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000BA274 ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000610EFA ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043F369 ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 ULK2 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000076E54 ULK2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B ULK2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000018E72A ULK2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001DABC0 ULK2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000292B1 ULK2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B ULK2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC ULK2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 ULK2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 ULK2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 ULK2 25416803 26920049 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00004F2EB0 ULK2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 ULK2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002152A8 ULK2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000AB32B ULK2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075A760 ULK2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 ULK2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 ULK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001496AE ULK2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 ULK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D ULK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027352D ULK2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA ULK2 22135298 phosphorylation N/A PhosphoSite
ULK2 SEC16A 22135298 phosphorylation N/A PhosphoSite
ULK2 DENND3 22135298 phosphorylation N/A PhosphoSite
RPTOR ULK2 25361965 interaction type N/A PTMCode2
ULK2 RPTOR 25361965 interaction type N/A PTMCode2
RB1CC1 ULK2 25361965 interaction type N/A PTMCode2
ULK2 RB1CC1 25361965 interaction type N/A PTMCode2
ULK2 SYNGAP1 25361965 interaction type N/A PTMCode2
SYNGAP1 ULK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAA2 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
GLRX3 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CLNS1A ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ZNF32 ULK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GABARAPL2 ULK2 20562859 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
MAP1LC3B ULK2 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
CSNK1D ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SETDB1 ULK2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MAPK3 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
FLNA ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAA1 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CKAP4 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PLK1 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SQSTM1 ULK2 25348397 N/A physical interaction ComPPI
HNRNPA2B1 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
YWHAH ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
YWHAE ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
GABARAP ULK2 20562859 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SYNGAP1 ULK2 14525934 15014045 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
CDC37 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP5C ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RB1CC1 ULK2 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R1B ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MTA2 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DIXDC1 ULK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKAB2 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAG1 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAB1 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAG2 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NASP ULK2 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
LNX1 ULK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LUC7L2 ULK2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EEF1B2 ULK2 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
POLA2 ULK2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ULK2 CBX6 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ULK2 IRF1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ULK2 GABARAPL1 20562859 24234451 25348397 physical association pull down ComPPI,IntAct
ULK2 CREB1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 SSBP3 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 AASDHPPT 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 HBS1L 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 IPO9 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 WDR26 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 PYCR3 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 OBSL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 GLDC 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 PPP2R2D 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 ATG13 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 ATG101 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 DBN1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 KIF11 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
WDR6 ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ULK2 ULK2 20562859 24234451 association,physical association anti tag coimmunoprecipitation IntAct
ULK2 PRKAA2 21460634 27898060 inhibition N/A OmniPath
PRKACA ULK2 26052940 27898060 N/A N/A OmniPath
ULK2 PRKAB1 21460634 27898060 inhibition N/A OmniPath
ATG13 ULK2 18936157 19225151 27898060 stimulant N/A OmniPath
ULK2 ATG13 18936157 19225151 20562859 27898060 stimulant N/A OmniPath
TP53 ULK2 21475306 27898060 N/A N/A OmniPath
ULK2 RB1CC1 19225151 20562859 27898060 stimulant N/A OmniPath
RB1CC1 ULK2 18936157 19225151 27898060 stimulant N/A OmniPath
SQSTM1 ULK2 14702098 27898060 N/A N/A OmniPath
MTOR ULK2 19211836 19225151 27898060 inhibition N/A OmniPath
ULK2 PRKAG3 21460634 27898060 inhibition N/A OmniPath

Visualization










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