Gene Information gene info

  1. Home

GENE：ZEB1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ZEB1
FullNmae zinc finger E-box binding homeobox 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11642
EnsembleID ENSG00000148516
Uniprot P37275

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ZEB1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ZEB1 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ZEB1 GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0006357,GO:0007389,GO:0008270,GO:0010464,GO:0010839,GO:0014823,GO:0017015,GO:0030154,GO:0030900,GO:0031667,GO:0033081,GO:0043616,GO:0045602,GO:0045666,GO:0045892,GO:0045892,GO:0045944,GO:0048596,GO:0048704,GO:0048752,GO:0048856,GO:0051150,GO:0051216,GO:0070888,GO:0071230,GO:0071560,GO:0090103

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ZEB1 hsa:6935 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
ZEB1 hsa:6935 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
ZEB1 hsa:6935 path:hsa05215 Prostate cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ZEB1 LMO2 10048576 11528470 13130303 16556862 16716598 19208835 19839049 20589835 20731704 21081489 21224848 22349261 22439866 225147423 26192618 7768934 9278421 9811054 association N/A ACSN
SMAD4 ZEB1 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 26192618 9389648 interaction type N/A ACSN
SMAD3 ZEB1 11074002 11279127 11792802 12702545 12809600 14976548 15265520 16179589 16713975 16831886 18768831 18832382 19208835 19597490 20731704 21042762 21317430 21614932 22331441 26192618 8515656 8893010 9389648 interaction type N/A ACSN
SNAI1 ZEB1 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 26192618 8844971 9157999 9618481 interaction type N/A ACSN
TWIST1 ZEB1 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21502402 21733352 2191300 21919891 22406545 22945800 26192618 7768934 9278421 interaction type N/A ACSN
HMGA2 ZEB1 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 26192618 9389648 interaction type N/A ACSN
ZEB1 MMP1 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 26192618 28212565 9811054 interaction type N/A ACSN
ZEB1 VEGFA 10048576 11528470 13130303 16556862 16716598 19208835 19839049 20589835 20731704 21081489 21224848 22349261 22439866 225147423 26192618 7768934 9278421 9811054 interaction type N/A ACSN
ZEB1 TCF3 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 26192618 28212565 9811054 interaction type N/A ACSN
ZEB1 PATJ 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 26192618 28212565 9811054 interaction type N/A ACSN
ZEB1 BMI1 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 26192618 28212565 9811054 interaction type N/A ACSN
CDH1 ZEB1 10949939 23180781 physical association electrophoretic mobility supershift assay InnateDB
ZEB1 CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ZEB1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 ZEB1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ZEB1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ZEB1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ZEB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EP300 ZEB1 16804902 trascriptional regulation,stimulation inferred by curator TFlink
ERG ZEB1 21747944 trascriptional regulation,stimulation inferred by curator TFlink
KCNH2 ZEB1 21747944 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 ZEB1 22391641 trascriptional regulation,stimulation inferred by curator TFlink
GATA3 ZEB1 20731704 trascriptional regulation,stimulation inferred by curator TFlink
KAT2B ZEB1 22384255 trascriptional regulation,stimulation inferred by curator TFlink
LMO2 ZEB1 20731704 trascriptional regulation,stimulation inferred by curator TFlink
PCGF2 ZEB1 23474752 trascriptional regulation,stimulation inferred by curator TFlink
SALL4 ZEB1 23954296 trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 ZEB1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB ZEB1 22847613 rna interference,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000003E1A9 ZEB1 18411277 19854497 \N rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000016FD1A ZEB1 23013135 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000008DA94 ZEB1 18376396 18381893 18411277 18829540 19703993 19854497 21049046 \N rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000012A1DD ZEB1 18376396 18411277 18829540 19839049 19854497 21049046 \N rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000171525 ZEB1 16929162 18381893 18411277 18483486 19839049 19854497 20049172 21049046 21294122 22407310 22569286 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000016914 ZEB1 18376396 rna interference,inhibition array technology,experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS000055BBE5 ZEB1 18411277 18829540 19854497 \N rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000171525 ZEB1 16929162 18381893 18411277 18483486 18927107 19502803 19839049 19854497 20049172 21049046 21125666 21224848 21294122 21389093 21527937 21867514 22012804 22247255 22407310 22569286 22735571 22743998 23318420 23497265 23622248 23754305 23765923 23807165 23869586 24127332 24615544 25416803 25502084 27930974 28334634 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,chromatin immunoprecipitation assay,rna immunoprecipitation,quantitative reverse transcription pcr,immunohistochemistry,clash,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS000003E1A9 ZEB1 18411277 18927107 19502803 19854497 22012804 25416803 25502084 26160158 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000008DA94 ZEB1 18376396 18381893 18411277 18829540 18927107 19703993 19854497 21049046 21125666 21389093 21874049 23381389 24127332 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000012A1DD ZEB1 18376396 18411277 18829540 18927107 19839049 19854497 21049046 21125666 21389093 21874049 22247255 22294131 23318420 23408168 25411357 25416803 27307751 27373709 28028835 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000055BBE5 ZEB1 18411277 18829540 18927107 19854497 19910931 22247255 25416803 26472725 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000016914 ZEB1 18376396 19502803 22473208 22555458 23474752 25416803 27082508 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000016FD1A ZEB1 23013135 23765923 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C0FCB ZEB1 22847613 25416803 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 ZEB1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000183BED ZEB1 23844063 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00002F3336 ZEB1 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS00004DA9DB ZEB1 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS0000535FDD ZEB1 23105110 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000039607D ZEB1 23105110 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00005E1A16 ZEB1 23690952 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000345DEB ZEB1 24277930 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000016FF9C ZEB1 24277930 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001E0AEA ZEB1 23342264 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001CF056 ZEB1 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000ECE9C ZEB1 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002E92A8 ZEB1 25416803 27785072 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000272039 ZEB1 25416803 26556542 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000081E1F ZEB1 25416803 27079864 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001270D3 ZEB1 25416803 25868853 26459797 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00005651EE ZEB1 25416803 28286418 mrna cleavage,inhibition experimental interaction detection,western blot TarBase
URS0000013DD8 ZEB1 25416803 26498682 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004AC389 ZEB1 25416803 25896413 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00000B7E30 ZEB1 25416803 27744452 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000AD002 ZEB1 25416803 26801503 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 ZEB1 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000013D17D ZEB1 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00005C1F22 ZEB1 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CTBP1 ZEB1 25361965 interaction type N/A PTMCode2
ZEB1 CTBP1 25361965 interaction type N/A PTMCode2
CTBP2 ZEB1 25361965 interaction type N/A PTMCode2
ZEB1 CTBP2 25361965 interaction type N/A PTMCode2
DRAP1 ZEB1 25361965 interaction type N/A PTMCode2
ZEB1 DRAP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDK6 ZEB1 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
TP53BP1 ZEB1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
GTF2A1 ZEB1 25348397 N/A physical interaction ComPPI
SMAD1 ZEB1 25348397 N/A physical interaction ComPPI
SMAD7 ZEB1 20514018 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CREBBP ZEB1 25348397 N/A physical interaction ComPPI
SMAD2 ZEB1 12743038 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EP300 ZEB1 12743039 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD3 ZEB1 12743038 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
USP7 ZEB1 25348397 N/A physical interaction ComPPI
CTBP1 ZEB1 10359772 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CTBP2 ZEB1 12714599 14525934 25348397 9724649 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SERPINH1 ZEB1 25348397 N/A physical interaction ComPPI
SMARCA4 ZEB1 25348397 N/A physical interaction ComPPI
EWSR1 ZEB1 25348397 N/A physical interaction ComPPI
ATM ZEB1 25348397 N/A physical interaction ComPPI
USP13 ZEB1 25348397 N/A physical interaction ComPPI
MPHOSPH8 ZEB1 25348397 N/A physical interaction ComPPI
CHEK1 ZEB1 25348397 N/A physical interaction ComPPI
SOX2 ZEB1 25348397 N/A physical interaction ComPPI
SYNCRIP ZEB1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZEB1 DRAP1 14525934 25348397 27898060 9418848 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
ZEB1 KAT5 11275565 14525934 25348397 27898060 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD,OmniPath
ZEB1 SMAD6 25348397 N/A physical interaction ComPPI
ZEB1 SIRT1 22249256 25086746 25348397 25870236 27898060 N/A physical interaction ComPPI,OmniPath
ZEB1 UBR4 25348397 N/A physical interaction ComPPI
ZEB1 DCAF15 25348397 N/A physical interaction ComPPI
ZEB1 ZMIZ1 25348397 N/A physical interaction ComPPI
ZEB1 USP10 25348397 N/A physical interaction ComPPI
ZEB1 USP26 25348397 N/A physical interaction ComPPI
ZEB1 USP29 25348397 N/A physical interaction ComPPI
ZEB1 USP42 25348397 N/A physical interaction ComPPI
ZEB1 USP51 25348397 N/A physical interaction ComPPI
ZEB1 PAN2 25348397 N/A physical interaction ComPPI
ZEB1 USP54 25348397 N/A physical interaction ComPPI
ZEB1 UCHL3 25348397 N/A physical interaction ComPPI
ZEB1 VCPIP1 25348397 N/A physical interaction ComPPI
USP53 ZEB1 25348397 N/A physical interaction ComPPI
STK38L ZEB1 24234451 30108113 association proximity-dependent biotin identification IntAct
SMARCA4 ZEB1 20418909 27898060 stimulant N/A OmniPath

Visualization










  Return