Gene Information gene info

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GENE：RNF8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RNF8
FullNmae ring finger protein 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10071
EnsembleID ENSG00000112130
Uniprot O76064

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RNF8 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RNF8 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RNF8 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RNF8 GO:0000151,GO:0000151,GO:0000781,GO:0003682,GO:0004842,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005829,GO:0005829,GO:0006302,GO:0006302,GO:0006303,GO:0006511,GO:0006511,GO:0006974,GO:0007049,GO:0008270,GO:0010212,GO:0030496,GO:0031625,GO:0034244,GO:0035092,GO:0035861,GO:0035861,GO:0036297,GO:0040029,GO:0042393,GO:0042393,GO:0042770,GO:0042802,GO:0042803,GO:0043130,GO:0045190,GO:0045739,GO:0051301,GO:0051865,GO:0061630,GO:0070534,GO:0070936,GO:0070936,GO:0140861

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 RNF8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RNF8 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RNF8 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RNF8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RNF8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RNF8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 RNF8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RNF8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RNF8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RNF8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RNF8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RNF8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CHD4 RNF8 22531782 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000032FC1A RNF8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D RNF8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 RNF8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC RNF8 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 RNF8 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 RNF8 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UBE2E1 RNF8 25361965 interaction type N/A PTMCode2
RNF8 UBE2E1 25361965 interaction type N/A PTMCode2
ATM RNF8 25361965 interaction type N/A PTMCode2
RNF8 ATM 25361965 interaction type N/A PTMCode2
RNF8 TP53BP1 25361965 interaction type N/A PTMCode2
TP53BP1 RNF8 25361965 interaction type N/A PTMCode2
RNF8 MDC1 25361965 interaction type N/A PTMCode2
MDC1 RNF8 25361965 interaction type N/A PTMCode2
RNF8 RXRA 25361965 interaction type N/A PTMCode2
RXRA RNF8 25361965 interaction type N/A PTMCode2
BRCA1 RNF8 25361965 interaction type N/A PTMCode2
RNF8 BRCA1 25361965 interaction type N/A PTMCode2
UBE2N RNF8 25361965 interaction type N/A PTMCode2
RNF8 UBE2N 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRTAP9-2 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LMO4 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WASHC3 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WASL RNF8 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-8 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX11 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PCNA RNF8 25348397 N/A physical interaction ComPPI
TP53BP1 RNF8 18001825 24234451 25348397 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct
VCP RNF8 25348397 N/A physical interaction ComPPI
UBE2D1 RNF8 25348397 N/A physical interaction ComPPI
TNIP1 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCDC85B RNF8 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UBE2E2 RNF8 11322894 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
GPRASP2 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2E3 RNF8 11322894 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TMEM79 RNF8 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PNMA2 RNF8 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PICK1 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK1 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D2 RNF8 19690564 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBB RNF8 25348397 N/A pull down,physical interaction ComPPI
UBC RNF8 25348397 N/A pull down,physical interaction,physical interaction ComPPI
RPS27A RNF8 25348397 N/A pull down,physical interaction ComPPI
UBA52 RNF8 25348397 N/A pull down,physical interaction ComPPI
UBE2N RNF8 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XRCC5 RNF8 25348397 N/A pull down,physical interaction,physical interaction ComPPI
DNTTIP2 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNFRSF1A RNF8 25348397 N/A physical interaction ComPPI
CLK2 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TPR RNF8 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
CALCOCO1 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM29 RNF8 25348397 N/A physical interaction ComPPI
TNF RNF8 25348397 N/A physical interaction ComPPI
BLM RNF8 25348397 N/A physical interaction ComPPI
ATM RNF8 18001825 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
H2BC21 RNF8 25348397 N/A physical interaction ComPPI
ORC2 RNF8 18001825 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
JMJD1C RNF8 25348397 N/A anti bait coimmunoprecipitation,pull down,physical interaction,physical interaction ComPPI
RNF8 EXOSC2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RNF8 UBE2E1 11322894 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
RNF8 CEP44 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
RNF8 MDC1 14525934 18001824 18001825 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,pull down,physical interaction,fluorescence microscopy,in vitro,confocal microscopy ComPPI,HPRD,IntAct
RNF8 RXRA 14525934 14981089 16189514 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
RNF8 UBE2W 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RNF8 MGMT 25348397 N/A physical interaction ComPPI
RNF8 HERC2 25348397 N/A anti bait coimmunoprecipitation,physical interaction,physical interaction ComPPI
RNF8 HERC2P3 25348397 N/A physical interaction ComPPI
RNF8 CHD4 22531782 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
RNF8 KDM4A 25348397 N/A physical interaction ComPPI
RNF8 UBE2V2 25348397 N/A physical interaction ComPPI
RNF8 CHEK2 25348397 N/A pull down,physical interaction,physical interaction ComPPI
RNF8 YEATS4 25348397 N/A physical interaction ComPPI
RNF8 UBE2D3 25348397 N/A physical interaction ComPPI
RNF8 RAD50 25348397 N/A physical interaction ComPPI
RNF8 MRE11 25348397 N/A physical interaction ComPPI
RNF8 NBN 18001825 24234451 25348397 26869104 colocalization,physical association anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
RNF8 H2AC20 25348397 N/A physical interaction ComPPI
RNF8 H2AX 18001824 18001825 24234451 25348397 colocalization physical interaction,fluorescence microscopy,confocal microscopy ComPPI,IntAct
RNF8 RPSA 25348397 N/A physical interaction ComPPI
RNF8 SEPTIN7 25348397 N/A physical interaction ComPPI
RNF8 SEPTIN8 25348397 N/A physical interaction ComPPI
RNF8 MDM2 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RNF8 USP16 25348397 N/A physical interaction ComPPI
RNF8 MAD1L1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RNF8 RBFOX2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RNF8 SEPTIN3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RNF8 HOMEZ 25348397 N/A physical interaction ComPPI
RNF8 WRAP53 25348397 N/A physical interaction ComPPI
RNF8 VRK1 24234451 25348397 26869104 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF8 MAGED1 25348397 N/A physical interaction ComPPI
RNF8 BARD1 25348397 N/A physical interaction ComPPI
RNF8 POLD4 25348397 N/A physical interaction ComPPI
RNF8 FOXM1 25348397 N/A physical interaction ComPPI
RNF8 DYRK2 25348397 N/A physical interaction ComPPI
RNF8 TRIM25 25348397 N/A physical interaction ComPPI
RNF8 UBE2S 25348397 N/A physical interaction ComPPI
RNF8 SUMO2 25348397 N/A physical interaction ComPPI
RNF8 SUMO3 25348397 N/A physical interaction ComPPI
RNF8 PRPF19 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
RNF8 RUVBL2 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
RNF8 ERCC1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
RNF8 ERCC4 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
RNF8 BRCA1 18001825 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
RNF8 MCPH1 18001825 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
RNF8 C2CD6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 CLK3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 FAM9B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 KRTAP9-8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 ZNF346 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 ZNF496 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 PCYT1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 CCDC50 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 DNM2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 SCN3B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 FSD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 TOMM20L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 AMOTL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
H3-3A RNF8 25348397 N/A physical interaction ComPPI
BCL10 RNF8 25348397 N/A physical interaction ComPPI
PSMB1 RNF8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNF8 RNF8 22980979 24234451 physical association two hybrid array,x ray scattering,two hybrid prey pooling approach IntAct
PRKDC RNF8 24234451 30021884 physical association cross-linking study IntAct
TPP1 RNF8 22101936 27898060 N/A N/A OmniPath
RNF8 H2AZ1 18001824 19797077 27898060 stimulant N/A OmniPath
RNF8 H2BC11 19015238 27898060 stimulant N/A OmniPath
MDC1 RNF8 18001824 18001825 18006705 18082599 18678647 24240613 25512560 26734725 27898060 stimulant N/A OmniPath
RNF8 RAD18 19396164 27898060 stimulant N/A OmniPath
RNF8 H2AC20 18001824 27898060 stimulant N/A OmniPath
RNF8 RNF168 20385750 27898060 stimulant N/A OmniPath
RNF8 H2AX 18001824 18001825 22980979 26507658 27898060 stimulant N/A OmniPath
HERC2 RNF8 20023648 22508508 22814251 25305019 27898060 stimulant N/A OmniPath
RNF8 UBE2N 16215985 18678647 19549727 20023648 21911360 22589545 22814251 23255131 24732096 25909880 26285145 27898060 stimulant N/A OmniPath
RNF8 H2AC11 20551964 27898060 stimulant N/A OmniPath

Visualization










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