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GENE：DPP4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DPP4
FullNmae dipeptidyl peptidase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3009
EnsembleID ENSG00000197635
Uniprot P27487

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DPP4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DPP4 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DPP4 GO:0001618,GO:0001662,GO:0001666,GO:0002020,GO:0004177,GO:0004252,GO:0005102,GO:0005515,GO:0005576,GO:0005765,GO:0005886,GO:0005886,GO:0005886,GO:0005925,GO:0006508,GO:0006508,GO:0007155,GO:0008236,GO:0008239,GO:0008239,GO:0008284,GO:0009986,GO:0010716,GO:0016020,GO:0016324,GO:0016486,GO:0019065,GO:0030027,GO:0030139,GO:0031258,GO:0031295,GO:0033632,GO:0035641,GO:0036343,GO:0042110,GO:0042802,GO:0042803,GO:0043542,GO:0045121,GO:0045499,GO:0045499,GO:0046581,GO:0046718,GO:0046813,GO:0050919,GO:0061025,GO:0070062,GO:0090024,GO:0120116

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DPP4 hsa:1803 path:hsa04974 Protein digestion and absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CCL22 DPP4 23180781 9933589 protein cleavage chromatography technology InnateDB
DPP4 KCND3 15911355 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR DPP4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DPP4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 DPP4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DPP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DPP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DPP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DPP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DPP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 DPP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DPP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DPP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DPP4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CCL11 DPP4 25361965 interaction type N/A PTMCode2
DPP4 CCL11 25361965 interaction type N/A PTMCode2
CXCL11 DPP4 25361965 interaction type N/A PTMCode2
DPP4 CXCL11 25361965 interaction type N/A PTMCode2
CD4 DPP4 25361965 interaction type N/A PTMCode2
DPP4 CD4 25361965 interaction type N/A PTMCode2
CCL5 DPP4 25361965 interaction type N/A PTMCode2
DPP4 CCL5 25361965 interaction type N/A PTMCode2
CXCL10 DPP4 25361965 interaction type N/A PTMCode2
DPP4 CXCL10 25361965 interaction type N/A PTMCode2
DPP4 CXCL9 25361965 interaction type N/A PTMCode2
CXCL9 DPP4 25361965 interaction type N/A PTMCode2
DPP4 PTPRC 25361965 interaction type N/A PTMCode2
PTPRC DPP4 25361965 interaction type N/A PTMCode2
DPP4 CCL3 25361965 interaction type N/A PTMCode2
CCL3 DPP4 25361965 interaction type N/A PTMCode2
DPP4 CXCR4 25361965 interaction type N/A PTMCode2
CXCR4 DPP4 25361965 interaction type N/A PTMCode2
CCL22 DPP4 25361965 interaction type N/A PTMCode2
DPP4 CCL22 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GIP DPP4 21314817 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CXCL9 DPP4 11390394 14525934 18275857 21314817 24234451 25348397 cleavage reaction experimental interaction detection,enzymatic study,protease assay,in vitro ComPPI,HPRD,IntAct
DKK1 DPP4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NPPB DPP4 21314817 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
CD4 DPP4 14525934 25348397 7539755 N/A experimental interaction detection,in vitro ComPPI,HPRD
FAP DPP4 14525934 25348397 7911242 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CCL5 DPP4 11390394 14525934 21314817 24234451 25348397 27898060 9516414 cleavage reaction experimental interaction detection,protease assay,in vitro ComPPI,HPRD,IntAct,OmniPath
IKBKB DPP4 25348397 N/A physical interaction ComPPI
ADCYAP1 DPP4 21314817 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
EGFR DPP4 25348397 N/A physical interaction ComPPI
DPP4 CXCL12 11390394 14525934 21314817 24234451 25348397 cleavage reaction experimental interaction detection,enzymatic study,protease assay,in vitro ComPPI,HPRD,IntAct
DPP4 CCL11 11390394 14525934 18275857 21314817 24234451 25348397 cleavage reaction experimental interaction detection,enzymatic study,protease assay,in vitro ComPPI,HPRD,IntAct
DPP4 CCL3L1 10961862 11390394 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
DPP4 CCL22 11390394 14525934 21314817 24234451 25348397 9933589 cleavage reaction experimental interaction detection,physical interaction,protease assay,in vitro,in vivo ComPPI,HPRD,IntAct
DPP4 GRP 11696365 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DPP4 CXCR4 11278278 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
DPP4 ADA 11772392 14525934 25348397 N/A electron microscopy,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DPP4 CXCL10 11390394 14525934 18275857 21314817 24234451 25348397 cleavage reaction experimental interaction detection,enzymatic study,protease assay,in vitro ComPPI,HPRD,IntAct
DPP4 PTPRC 1680916 25348397 27898060 N/A coimmunoprecipitation,physical interaction,in vivo ComPPI,OmniPath
DPP4 CARD11 25348397 N/A physical interaction ComPPI
DPP4 TUBGCP2 18275857 24234451 25348397 N/A enzymatic study ComPPI,IntAct
DPP4 CXCL2 18275857 21314817 24234451 25348397 cleavage reaction enzymatic study,protease assay ComPPI,IntAct
DPP4 GCG 21314817 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
DPP4 VIP 21314817 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
DPP4 GHRH 21314817 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
DPP4 PYY 21314817 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
DPP4 NPY 21314817 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
DPP4 TAC1 21314817 24234451 25348397 cleavage reaction protease assay ComPPI,IntAct
DPP4 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
CXCL11 DPP4 11390394 14525934 18275857 21314817 24234451 25348397 cleavage reaction experimental interaction detection,enzymatic study,protease assay,in vitro ComPPI,HPRD,IntAct
BCL10 DPP4 25348397 N/A physical interaction ComPPI
DPP4 DPP4 11696365 14525934 22001206 24234451 physical association circular dichroism,cosedimentation in solution,experimental interaction detection,comigration in gel electrophoresis HPRD,IntAct
CXCL12 DPP4 11390394 21314817 24218476 27898060 N/A N/A OmniPath
CXCL11 DPP4 11390394 18275857 21314817 24218476 27898060 N/A N/A OmniPath
CXCL10 DPP4 11390394 18275857 21314817 24218476 27898060 N/A N/A OmniPath
CXCL9 DPP4 11390394 18275857 21314817 24218476 27898060 N/A N/A OmniPath
CCL11 DPP4 11390394 18275857 21314817 24218476 27898060 N/A N/A OmniPath
CCL22 DPP4 11390394 21314817 24218476 27898060 9933589 N/A N/A OmniPath
DPP4 CCL22 11390394 21314817 27898060 9933589 N/A N/A OmniPath
CXCL2 DPP4 18275857 21314817 24218476 27898060 N/A N/A OmniPath
GIP DPP4 15655705 21314817 27898060 N/A N/A OmniPath
GPC3 DPP4 17549790 27898060 inhibition N/A OmniPath

Visualization










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