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GENE：SFRP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SFRP2
FullNmae secreted frizzled related protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10777
EnsembleID ENSG00000145423
Uniprot Q96HF1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SFRP2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SFRP2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SFRP2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SFRP2 GO:0001569,GO:0001968,GO:0002063,GO:0003151,GO:0003214,GO:0003402,GO:0005178,GO:0005615,GO:0005615,GO:0005615,GO:0007267,GO:0007501,GO:0007584,GO:0008284,GO:0008285,GO:0008285,GO:0008584,GO:0009410,GO:0010629,GO:0010659,GO:0010667,GO:0010719,GO:0010975,GO:0017147,GO:0017147,GO:0030178,GO:0030178,GO:0030199,GO:0030307,GO:0030308,GO:0030336,GO:0030509,GO:0030514,GO:0031668,GO:0033138,GO:0033630,GO:0035567,GO:0036342,GO:0042662,GO:0042733,GO:0043065,GO:0045600,GO:0045669,GO:0045766,GO:0045892,GO:0045944,GO:0048018,GO:0048546,GO:0048866,GO:0050680,GO:0050732,GO:0060028,GO:0060070,GO:0061056,GO:0061133,GO:0061185,GO:0062023,GO:0071425,GO:0071481,GO:0090090,GO:0090179,GO:0090244,GO:0090263,GO:1902042,GO:1902230,GO:1904956,GO:2000035,GO:2000041

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SFRP2 hsa:6423 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SFRP2 WNT4 11287180 18988627 23331499 9853965 interaction type N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 SFRP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SFRP2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SFRP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SFRP2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SFRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SFRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SFRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SFRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 SFRP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PAX2 SFRP2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000076995 SFRP2 20551325 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000076995 SFRP2 20551325 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SFRP2 WNT4 25361965 interaction type N/A PTMCode2
WNT4 SFRP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPP1CC SFRP2 25348397 N/A physical interaction ComPPI
PPP1CB SFRP2 25348397 N/A physical interaction ComPPI
SMAD4 SFRP2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PAX2 SFRP2 14561758 25348397 27898060 N/A in vitro ComPPI,OmniPath
SFRP2 WNT4 14525934 25348397 9853965 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SFRP2 WNT1 10654605 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SFRP2 ARMC8 25348397 N/A physical interaction ComPPI
SFRP2 MAEA 25348397 N/A physical interaction ComPPI
SFRP2 MKLN1 25348397 N/A physical interaction ComPPI
SFRP2 RMND5A 25348397 N/A physical interaction ComPPI
SFRP2 RANBP9 25348397 N/A physical interaction ComPPI
SFRP2 PPP1CA 25348397 N/A physical interaction ComPPI
SFRP2 DBNDD2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 EEF1G 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 PFKM 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 BMPR1A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 CDH1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 DCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 RAD54B 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SFRP2 CCAR1 24234451 30021884 physical association cross-linking study IntAct
SFRP2 WNT1 10654605 27898060 inhibition N/A OmniPath
PAX6 SFRP2 11069887 20027618 27898060 stimulant N/A OmniPath
SFRP2 WNT4 1128718 27898060 9853965 inhibition N/A OmniPath

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