GENE：ABCC1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ABCC1 |
| FullNmae | ATP binding cassette subfamily C member 1 (ABCC1 blood group) |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:51 |
| EnsembleID | ENSG00000103222 |
| Uniprot | P33527 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ABCC1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ABCC1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ABCC1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ABCC1 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ABCC1 | GO:0005524,GO:0005886,GO:0005886,GO:0006691,GO:0006805,GO:0008559,GO:0009410,GO:0009925,GO:0015420,GO:0015431,GO:0015562,GO:0015562,GO:0015889,GO:0016020,GO:0016323,GO:0016323,GO:0016323,GO:0016324,GO:0016328,GO:0016887,GO:0034040,GO:0034599,GO:0034634,GO:0034634,GO:0034775,GO:0042167,GO:0042626,GO:0042908,GO:0042908,GO:0042910,GO:0042910,GO:0042910,GO:0043225,GO:0045332,GO:0046943,GO:0050729,GO:0055085,GO:0060326,GO:0070062,GO:0070633,GO:0070729,GO:0071716,GO:0098656,GO:0099039,GO:0140115,GO:0140115,GO:0140359,GO:0140359,GO:0150104,GO:1904646,GO:1905039,GO:1990962 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ABCC1 | hsa:4363 | path:hsa01523 | Antifolate resistance - Homo sapiens (human) |
| ABCC1 | hsa:4363 | path:hsa02010 | ABC transporters - Homo sapiens (human) |
| ABCC1 | hsa:4363 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| ABCC1 | hsa:4363 | path:hsa04977 | Vitamin digestion and absorption - Homo sapiens (human) |
| ABCC1 | hsa:4363 | path:hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| STING1 | ABCC1 | 21903422 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| UNC93B1 | ABCC1 | 21903422 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NOTCH1 | ABCC1 | 23180781 24782036 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ABCC1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | ABCC1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | ABCC1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | ABCC1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ABCC1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | ABCC1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | ABCC1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ABCC1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| NFE2L2 | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ABCC1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYCN | ABCC1 | 10348353 14737110 7923112 9516823 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | ABCC1 | 23765166 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | ABCC1 | 23765166 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000272A92 | ABCC1 | 20371173 | rna interference,inhibition | western blot,northern blot,quantitative reverse transcription pcr | miRSponge |
| URS000005D4F5 | ABCC1 | 20099276 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS000005D4F5 | ABCC1 | 20099276 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000272A92 | ABCC1 | 20371173 25416803 | mrna cleavage,inhibition | western blot,northern blot,quantitative reverse transcription pcr | TarBase |
| URS0000122ED0 | ABCC1 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000324096 | ABCC1 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00003D5391 | ABCC1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000003FD55 | ABCC1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000183BED | ABCC1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000047E28E | ABCC1 | 23686318 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS00003BD367 | ABCC1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CF1D2 | ABCC1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000080D0A | ABCC1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058276F | ABCC1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F4657 | ABCC1 | 23313552 25354783 25416803 | mrna cleavage,inhibition | clip,miRNA interference luciferase reporter assay | TarBase |
| URS0000029EBD | ABCC1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000184017 | ABCC1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CSNK2A1 | ABCC1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NDUFB9 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| RPS7 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| NPM1 | ABCC1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| NDUFAF3 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| VCP | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| CANX | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| CAV1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGES3 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| TRAF3 | ABCC1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| CSNK2A1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| EEF1A1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| VDAC1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| EIF3C | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| PDHX | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| STX4 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| PSMC5 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| VDAC2 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| RAVER1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| TMOD2 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| PSMD2 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS8 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| AZGP1 | ABCC1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| IDH3A | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| NR3C1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| FKBP8 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| PDCD6IP | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| SAFB | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| CLGN | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| PUF60 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| SEC63 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| FLOT1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| MRPL17 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| CTDSPL | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| ECHS1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| ATP5F1A | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| FASN | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| PAICS | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| VDAC3 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| TMEM33 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| EEF1A1P5 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| DBT | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| ATP6V1F | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| ATP6V1H | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| STING1 | ABCC1 | 21903422 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MCU | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| NFS1 | ABCC1 | 25348397 | N/A | physical interaction | ComPPI |
| ABCC1 | UNC93B1 | 25348397 | N/A | physical interaction | ComPPI |
| ABCC1 | TMX2 | 25348397 | N/A | physical interaction | ComPPI |
| ABCC1 | TMCO1 | 25348397 | N/A | physical interaction | ComPPI |
| ABCC1 | PGRMC2 | 25348397 | N/A | physical interaction | ComPPI |
| ABCC1 | STT3B | 25348397 | N/A | physical interaction | ComPPI |
| ABCC1 | SURF1 | 25348397 | N/A | physical interaction | ComPPI |
| ABCC1 | TMEM17 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| CLN6 | ABCC1 | 24234451 30177828 | association | anti tag coimmunoprecipitation | IntAct |
| CSNK2A1 | ABCC1 | 22695718 27898060 | stimulant | N/A | OmniPath |
| STING1 | ABCC1 | 21903422 27898060 | N/A | N/A | OmniPath |