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GENE：TGFBR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TGFBR1
FullNmae transforming growth factor beta receptor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11772
EnsembleID ENSG00000106799
Uniprot P36897

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TGFBR1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TGFBR1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TGFBR1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TGFBR1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TGFBR1 GO:0001501,GO:0001701,GO:0001822,GO:0001824,GO:0001837,GO:0001935,GO:0001937,GO:0001938,GO:0002088,GO:0003222,GO:0003223,GO:0004672,GO:0004674,GO:0005024,GO:0005024,GO:0005024,GO:0005025,GO:0005025,GO:0005114,GO:0005114,GO:0005515,GO:0005524,GO:0005634,GO:0005768,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005923,GO:0006355,GO:0006355,GO:0006468,GO:0006468,GO:0006915,GO:0007165,GO:0007179,GO:0007179,GO:0007179,GO:0007179,GO:0007179,GO:0007179,GO:0007399,GO:0007507,GO:0007507,GO:0008284,GO:0008354,GO:0008584,GO:0009791,GO:0009952,GO:0009986,GO:0010628,GO:0010717,GO:0010718,GO:0016361,GO:0018105,GO:0018107,GO:0019838,GO:0030199,GO:0030307,GO:0030335,GO:0031396,GO:0031625,GO:0032331,GO:0032924,GO:0032924,GO:0035556,GO:0036446,GO:0042060,GO:0042118,GO:0043062,GO:0043235,GO:0043410,GO:0043542,GO:0045121,GO:0045893,GO:0046332,GO:0046332,GO:0046332,GO:0046847,GO:0046872,GO:0048179,GO:0048185,GO:0048538,GO:0048663,GO:0048701,GO:0048705,GO:0048762,GO:0048844,GO:0048870,GO:0050431,GO:0050431,GO:0050431,GO:0051491,GO:0051496,GO:0051726,GO:0051897,GO:0060017,GO:0060021,GO:0060037,GO:0060043,GO:0060317,GO:0060391,GO:0060391,GO:0060412,GO:0060978,GO:0060982,GO:0070021,GO:0070021,GO:0070411,GO:0070723,GO:0071363,GO:0071560,GO:1901203,GO:1902462,GO:1905007,GO:1905075,GO:1905223,GO:2001235,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TGFBR1 hsa:7046 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04144 Endocytosis - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04218 Cellular senescence - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04520 Adherens junction - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05142 Chagas disease - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05161 Hepatitis B - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05200 Pathways in cancer - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05210 Colorectal cancer - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05226 Gastric cancer - Homo sapiens (human)
TGFBR1 hsa:7046 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TGFBR2 TGFBR1 10678166 11013220 11102446 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16446785 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 18988627 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21071413 21098712 21278795 21372296 21614932 21791611 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23331499 23784029 24132110 24336330 24403530 26192618 26201938 26966341 2871107 7594497 7890683 8515656 8576253 9311995 9865696 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
TGFB1 TGFBR1 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26192618 26201938 26966341 2871107 7594497 8515656 9311995 9865696 interaction type N/A ACSN
TGFBR1 PARD6A 11133108 14557817 15265520 15548370 15761148 15761153 16474430 17934056 19010789 19109155 19114990 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22315516 22703233 22949611 23331499 24132110 24336330 26192618 7594497 interaction type,stimulation N/A ACSN,SignaLink
FKBP1A TGFBR1 11226255 14766396 16720724 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink
IL6 TGFBR1 11306493 15099563 15356132 15573129 18209571 18555777 18555778 19581928 20138012 23034983 23567181 24011634 24346288 25002027 25582338 26192618 26201938 26268945 27557510 7590867 8837607 9845545 interaction type N/A ACSN
CAV1 TGFBR1 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26192618 26828520 interaction type N/A ACSN
TGFBR1 SMAD3 11274345 12957874 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 23331499 24132110 24336330 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
TGFBR1 SMAD2 11274345 12957874 14557817 15265520 15350225 16474430 17934056 18511908 18988627 20060931 20519943 21071413 21614932 22703233 23331499 24132110 24336330 26192618 9346908 9525694 9892009 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
SMAD7 TGFBR1 11279127 14657019 14722617 15148321 15265520 17314099 18988627 21071413 21791611 22286770 23331499 23784029 26192618 9215638 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
SMURF1 TGFBR1 12519765 12857866 14657019 14657501 14722617 14744429 15265520 15761148 21572392 22949611 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink
SMURF2 TGFBR1 14722617 15265520 22624557 26192618 interaction type,ubiquitination reaction,inhibition N/A ACSN,SignaLink
TGFBR1 EGF 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16424049 16474430 16572188 17070508 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26192618 26201938 26966341 2871107 7594497 8515656 interaction type N/A ACSN
TGFBR1 TRAF6 11013220 11133108 12154066 12717440 12724770 12767520 12809600 14557817 15265520 15548370 16474430 17673906 17934056 18758450 18922473 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 22943793 23331499 24132110 24336330 26192618 7594497 9865696 interaction type,stimulation N/A ACSN,SignaLink
TGFBR1 CCL2 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16127449 16424049 16474430 16572188 17070508 17404308 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19732719 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26192618 26201938 26966341 2871107 7594497 8515656 interaction type N/A ACSN
TGFBR1 CCL5 11279127 11792802 12809600 14557817 15003992 15099563 15265520 15653932 16127449 16424049 16474430 16572188 17070508 17404308 17768418 17934056 17979848 18423981 18490733 19038247 19109155 19732719 19747910 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 22703233 22874531 23034983 23784029 24132110 24336330 26192618 26201938 26966341 2871107 7594497 8515656 interaction type N/A ACSN
TGFBR1 MAP2K4 11274345 12738796 14557817 15265520 15282297 16200688 16474430 17934056 18855897 20060931 20519943 21614932 22703233 23070005 24132110 24336330 24403530 26192618 interaction type N/A ACSN
TGFBR1 MAP2K6 11274345 12738796 14557817 15265520 15282297 16200688 16474430 17934056 18855897 20060931 20519943 21614932 22703233 23070005 24132110 24336330 24403530 26192618 interaction type N/A ACSN
TGFBR1 SMAD4 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330 26192618 interaction type N/A ACSN
SQSTM1 TGFBR1 15761153 23180781 physical association luminescence based mammalian interactome mapping InnateDB
ACVRL1 TGFBR1 18333754 23180781 physical association anti tag coimmunoprecipitation,cross-linking study InnateDB
TGFBRAP1 TGFBR1 23180781 9545258 physical association anti tag coimmunoprecipitation InnateDB
TGFBR1 TGFB3 18243111 23180781 physical association surface plasmon resonance InnateDB
TGFBR1 TGFBR2 18243111 23180781 physical association surface plasmon resonance InnateDB
TGFB3 TGFBR1 18243111 23180781 physical association x-ray crystallography InnateDB
MAP3K20 TGFBR1 15465036 23180781 physical association anti tag coimmunoprecipitation InnateDB
TGFBR1 ENG 12015308 16785228 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
SMAD2 TGFBR1 23180781 8980228 9346908 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
TGFBR1 XIAP 19531477 23180781 physical association anti tag coimmunoprecipitation InnateDB
TAB1 TGFBR1 18316610 23180781 physical association anti tag coimmunoprecipitation InnateDB
ZFYVE16 TGFBR1 17272273 23180781 physical association anti tag coimmunoprecipitation InnateDB
STK17B TGFBR1 23122956 23180781 physical association anti tag coimmunoprecipitation InnateDB
SOX11 TGFBR1 23180781 24681958 physical association anti tag coimmunoprecipitation InnateDB
TGFBR1 TGFBR1 10973958 18758450 18922473 26467481 9346908 9865696 phosphorylation reaction,bind,up-regulates activity N/A Signor
SMAD6 TGFBR1 23331499 9892110 stimulation N/A SignaLink,SignaLink
BAMBI TGFBR1 10519551 23331499 stimulation N/A SignaLink,SignaLink
ZFYVE9 TGFBR1 12052882 18988627 23331499 9865696 stimulation N/A SignaLink,SignaLink
TGFBR1 ACVRL1 14580334 23331499 stimulation N/A SignaLink,SignaLink
TGFBR1 HIPK2 17729308 23331499 stimulation N/A SignaLink,SignaLink
DACT2 TGFBR1 19855013 23331499 stimulation N/A SignaLink,SignaLink
TGFBR1 EIF3I 23331499 9813058 stimulation N/A SignaLink,SignaLink
TGFBR1 CDC42 19114990 23331499 stimulation N/A SignaLink,SignaLink
USP4 TGFBR1 22706160 deubiquitination reaction,stimulation N/A SignaLink
DAB2 TGFBR1 11387212 23331499 stimulation N/A SignaLink
PPP1CC TGFBR1 14718519 23331499 stimulation N/A SignaLink
UCHL5 TGFBR1 17052192 23331499 stimulation N/A SignaLink
TGFBR1 SHC1 17673906 23331499 stimulation N/A SignaLink
TGFBR1 PIK3CG 15657037 23331499 stimulation N/A SignaLink
TGFBR1 MAP4K1 10224067 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CAV1 TGFBR1 20005715 interaction type N/A PSP
PIK3R1 TGFBR1 20005715 interaction type N/A PSP
RGS19 TGFBR1 20005715 interaction type N/A PSP
RHPN2 TGFBR1 20005715 interaction type N/A PSP
SKAP2 TGFBR1 20005715 interaction type N/A PSP
SNX6 TGFBR1 20005715 interaction type N/A PSP
SOCS6 TGFBR1 20005715 interaction type N/A PSP
SQSTM1 TGFBR1 20005715 interaction type N/A PSP
TGFBRAP1 TGFBR1 20005715 interaction type N/A PSP
CAV1 TGFBR1 11102446 18988627 20005715 21071413 N/A N/A SignaLink
SQSTM1 TGFBR1 15761153 18988627 20005715 N/A N/A SignaLink
PIK3R1 TGFBR1 20005715 21071413 9435577 N/A N/A SignaLink
RGS19 TGFBR1 15761153 18988627 20005715 N/A N/A SignaLink
RHPN2 TGFBR1 15761153 18988627 20005715 N/A N/A SignaLink
SKAP2 TGFBR1 15761153 18988627 20005715 N/A N/A SignaLink
SNX6 TGFBR1 20005715 N/A N/A SignaLink
SOCS6 TGFBR1 15761153 18988627 20005715 N/A N/A SignaLink
TGFBRAP1 TGFBR1 11278302 18988627 20005715 9545258 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR TGFBR1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 TGFBR1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 TGFBR1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TGFBR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TGFBR1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TGFBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TGFBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TGFBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TGFBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TGFBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TGFBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TGFBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TGFBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TGFBR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMAD7 TGFBR1 15221015 trascriptional regulation,stimulation inferred by curator TFlink
WWP1 TGFBR1 15221015 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000031E12 TGFBR1 19841744 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000821E0 TGFBR1 23401231 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 TGFBR1 20056717 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000031E12 TGFBR1 19841744 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000029D9F1 TGFBR1 20056717 23313552 25416803 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS00000821E0 TGFBR1 23401231 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001E0AEA TGFBR1 17612493 22473208 24558198 25416803 28146434 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000122ED0 TGFBR1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000A07C1 TGFBR1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000315338 TGFBR1 22942087 25416803 mrna cleavage,inhibition array technology TarBase
URS000029979D TGFBR1 24291274 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000324096 TGFBR1 24978044 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot TarBase
URS00003D8730 TGFBR1 25416803 28373289 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000065FDF TGFBR1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F TGFBR1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 TGFBR1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 TGFBR1 23592263 25416803 28095798 mrna cleavage,inhibition western blot,clip,miRNA interference luciferase reporter assay TarBase
URS00001B9F58 TGFBR1 23424236 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000001C659 TGFBR1 24802670 25416803 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002F5FEE TGFBR1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 TGFBR1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C TGFBR1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA TGFBR1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 TGFBR1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 TGFBR1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE TGFBR1 25416803 26714817 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000042E1F TGFBR1 25416803 26729221 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000018C928 TGFBR1 25416803 26682928 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
TGFBR2 TGFBR1 22135298 phosphorylation N/A PhosphoSite
TGFBR1 TGFBR3 22135298 phosphorylation N/A PhosphoSite
TGFBR1 SMAD2 22135298 phosphorylation N/A PhosphoSite
TGFBR1 EEF1A1 22135298 phosphorylation N/A PhosphoSite
TGFBR1 ENG 22135298 phosphorylation N/A PhosphoSite
TGFBR1 OTUB1 22135298 phosphorylation N/A PhosphoSite
PRKCA TGFBR1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIK3R2 TGFBR1 14525934 25348397 9435577 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CDC42 TGFBR1 25348397 N/A physical interaction ComPPI
SH3KBP1 TGFBR1 25348397 N/A physical interaction ComPPI
OXSR1 TGFBR1 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SKIL TGFBR1 25348397 N/A physical interaction ComPPI
TGFB1 TGFBR1 14525934 20856203 24234451 25348397 8235612 N/A coimmunoprecipitation,cross-linking study,experimental interaction detection,physical interaction,biochemical ComPPI,HPRD,IntAct
TRAF6 TGFBR1 14525934 18758450 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
FKBP1A TGFBR1 10025408 14525934 24234451 24658140 25348397 7518616 9346894 physical association experimental interaction detection,ubiquitin reconstruction,x-ray crystallography,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 TGFBR1 14525934 25348397 8774881 N/A experimental interaction detection,physical interaction ComPPI,HPRD
FBXO34 TGFBR1 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
APPL1 TGFBR1 25348397 N/A physical interaction ComPPI
CD44 TGFBR1 12145287 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PAK1 TGFBR1 25348397 N/A physical interaction ComPPI
SMURF2 TGFBR1 11163210 14525934 14722617 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DAB2 TGFBR1 11387212 14525934 24234451 25348397 association cross-linking study,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
TGFBR2 TGFBR1 14525934 25348397 7890683 8576253 N/A anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
OCLN TGFBR1 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD7 TGFBR1 14525934 15148321 25348397 9215638 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PIK3R1 TGFBR1 14525934 25348397 9435577 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NOTCH1 TGFBR1 25348397 N/A physical interaction ComPPI
SMAD2 TGFBR1 14525934 18511908 24234451 25348397 9346908 9525694 9892009 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
EP300 TGFBR1 25348397 N/A physical interaction ComPPI
SMAD3 TGFBR1 14525934 25348397 9311995 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MAPK14 TGFBR1 25348397 N/A physical interaction ComPPI
CLU TGFBR1 25348397 N/A physical interaction ComPPI
YWHAZ TGFBR1 19732720 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,pull down,fluorescence microscopy ComPPI,IntAct
HSP90AA1 TGFBR1 25348397 N/A physical interaction ComPPI
CANX TGFBR1 24234451 25348397 29568061 association pull down ComPPI,IntAct
CAV1 TGFBR1 11102446 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SNX6 TGFBR1 11279102 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
EPHA2 TGFBR1 25348397 N/A physical interaction ComPPI
BMPR2 TGFBR1 25348397 N/A physical interaction ComPPI
PARD6A TGFBR1 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ANK1 TGFBR1 25348397 N/A physical interaction ComPPI
RANBP9 TGFBR1 25348397 N/A physical interaction ComPPI
USP4 TGFBR1 25348397 N/A physical interaction ComPPI
AP2B1 TGFBR1 25348397 N/A physical interaction ComPPI
SPTBN1 TGFBR1 25348397 N/A physical interaction ComPPI
HSPA4 TGFBR1 25348397 N/A physical interaction ComPPI
RASSF1 TGFBR1 25348397 N/A physical interaction ComPPI
TGFB2 TGFBR1 25348397 N/A physical interaction,biochemical ComPPI
ACVRL1 TGFBR1 14525934 14580334 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TGFB3 TGFBR1 11850637 12060054 12607775 14525934 21423151 24234451 25348397 physical association experimental interaction detection,molecular sieving,surface plasmon resonance,physical interaction,ion exchange chromatography,blue native page,biochemical,surface plasmon resonance array ComPPI,HPRD,IntAct
STRAP TGFBR1 14525934 17314099 24234451 25348397 9856985 physical association experimental interaction detection,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
TGFBRAP1 TGFBR1 11278302 14525934 25348397 9545258 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
PPP2R2A TGFBR1 14525934 25348397 9774674 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MAP3K20 TGFBR1 14525934 15465036 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ITCH TGFBR1 25348397 N/A physical interaction ComPPI
TRAF4 TGFBR1 25348397 N/A physical interaction ComPPI
USP11 TGFBR1 25348397 N/A physical interaction ComPPI
MAP3K7 TGFBR1 14525934 18758450 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TAB2 TGFBR1 25348397 N/A physical interaction ComPPI
ARHGEF6 TGFBR1 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NLGN3 TGFBR1 24234451 25348397 26496610 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOLLIP TGFBR1 25348397 N/A physical interaction ComPPI
SMURF1 TGFBR1 25348397 N/A physical interaction ComPPI
TRIM25 TGFBR1 25348397 N/A physical interaction ComPPI
ACVR1 TGFBR1 14525934 15761153 24234451 24658140 25348397 physical association experimental interaction detection,ubiquitin reconstruction ComPPI,HPRD,IntAct
ELAVL1 TGFBR1 25348397 N/A physical interaction ComPPI
ENG TGFBR1 12015308 14525934 25348397 N/A anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD
FNTA TGFBR1 14525934 25348397 8530343 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
HMMR TGFBR1 25348397 N/A physical interaction ComPPI
SMAD6 TGFBR1 14525934 25348397 9335505 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MYOC TGFBR1 14525934 16289162 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
SKI TGFBR1 25348397 N/A physical interaction ComPPI
PEG10 TGFBR1 25348397 N/A physical interaction ComPPI
DLG5 TGFBR1 23624079 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
TSC22D1 TGFBR1 25348397 N/A physical interaction ComPPI
PSEN1 TGFBR1 25348397 N/A physical interaction ComPPI
ITGA5 TGFBR1 22940691 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
BAMBI TGFBR1 25348397 N/A physical interaction ComPPI
KCNK18 TGFBR1 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
LRG1 TGFBR1 23868260 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMP1 TGFBR1 24234451 25348397 29568061 association pull down ComPPI,IntAct
TGFBR1 HSP90AA2P 25348397 N/A physical interaction ComPPI
TGFBR1 USP15 25348397 N/A physical interaction ComPPI
TGFBR1 PPP1R16B 25348397 N/A physical interaction ComPPI
TGFBR1 OTUB1 25348397 N/A physical interaction ComPPI
TGFBR1 GOLT1B 25348397 N/A physical interaction ComPPI
TPM1 TGFBR1 25348397 N/A physical interaction ComPPI
NRP1 TGFBR1 25348397 N/A physical interaction ComPPI
TGFBR1 TGFBR1 14525934 9472030 N/A experimental interaction detection HPRD
AMHR2 TGFBR1 11420127 14525934 N/A experimental interaction detection HPRD
TGFBR1 SMAD1 10085121 14525934 9136927 9748228 N/A experimental interaction detection HPRD
BMPR1B TGFBR1 11420127 14525934 N/A experimental interaction detection HPRD
ZFYVE9 TGFBR1 14525934 9865696 N/A experimental interaction detection HPRD
TGFBR1 PML 14525934 15356634 N/A experimental interaction detection HPRD
TGFBR1 CTNNB1 12000714 14525934 N/A experimental interaction detection HPRD
ANAPC5 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
ARL4D TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
ARHGAP15 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
ARL8B TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
ASH2L TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
AURKB TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
BTBD2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CDC20 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CDC42EP4 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CDK4 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CDK6 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CDKL1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CHN1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CHN2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CHUK TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CSNK1A1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CSNK2A2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CUL5 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
DAPK2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PREX2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
DUSP13 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
EIF2AK4 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
ENC1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
FANCL TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
FBXL12 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
GNA13 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
GNB2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
GNB3 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
IKBKB TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
DCAF6 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
ITK TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
KATNB1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
KLHL1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
LIMS1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
MYO3A TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
NAT8 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
NEK6 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
NEK8 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
NKIRAS1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
NUP37 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CDK17 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CDK14 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PLEKHB1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PLEK TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PLK4 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PPP3CC TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PPP6C TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PREB TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PRPF4 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RAB13 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RAB25 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RAB33B TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RAB38 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RAB3B TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RAB6B TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RAN TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RAP2A TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RASL12 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RHEBL1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RHOA TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RHOD TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RHOG TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RHOH TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RHOJ TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RHPN2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RNF130 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RNF5 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RPS27A TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RRH TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RTKN TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
SAMD8 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
SAT2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
SKAP2 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
SNTG1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
SOCS6 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
STK35 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
STUB1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
STX8 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
STYXL1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 TNNT1 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 TSSK1B 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 TSSK4 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 TTC1 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 UBA52 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 UBB 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 UBD 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 UBE2E3 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 WDR13 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 WDR33 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 DCAF12 14525934 15761153 N/A experimental interaction detection HPRD
TGFBR1 WDR61 14525934 15761153 N/A experimental interaction detection HPRD
XIAP TGFBR1 11356828 14525934 N/A experimental interaction detection HPRD
TGFBR1 TRAP1 11278302 14525934 9545258 N/A experimental interaction detection,two hybrid HPRD
RPAP3 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
OSR1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
UBXN1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
KLHL35 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PLEKHJ1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
TTC27 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
POMK TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
TTPAL TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
ARHGAP31 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
UBE2Z TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
RGS19 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
SQSTM1 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
PRKCA TGFBR1 23290522 27898060 N/A N/A OmniPath
TGFBR1 PIK3R2 27898060 9435577 stimulant N/A OmniPath
FKBP1A TGFBR1 10025408 16720724 24658140 27898060 7518616 7791754 8756725 9346894 inhibition,stimulant N/A OmniPath
TGFBR1 RHOA 15761153 19726546 27898060 stimulant N/A OmniPath
TGFBR1 TGFBR2 10026191 11102446 11483955 12809600 18243111 19556242 19758997 21791611 23868260 25825445 27898060 7774578 7878020 7890683 8576253 inhibition N/A OmniPath
TGFBR2 TGFBR1 10026191 11102446 11483955 12809600 18243111 19556242 19758997 21791611 23868260 25825445 26194464 27898060 7774578 7878020 7890683 8576253 stimulant N/A OmniPath
TGFBR1 OTUB1 20553488 25872870 27898060 N/A N/A OmniPath
UCHL5 TGFBR1 17052192 27898060 stimulant N/A OmniPath
TGFBR1 TRAF6 18758450 18922473 24103590 25622187 26807171 27898060 stimulant N/A OmniPath
TGFBR1 SMAD1 10085121 19651622 27898060 9136927 9748228 stimulant N/A OmniPath
TGFBR1 XIAP 11356828 19531477 27898060 N/A N/A OmniPath
TGFBR1 RAC1 19726546 27898060 stimulant N/A OmniPath
HSP90AA1 TGFBR1 18591668 21465483 22848678 27898060 stimulant N/A OmniPath
TGFBR1 SHC1 17673906 27898060 stimulant N/A OmniPath
TGFBR1 PIK3R1 27898060 9435577 stimulant N/A OmniPath
TGFB1 TGFBR1 10187774 10716993 12809600 20856203 22326956 22703233 26194464 27898060 7706250 7852346 8235612 stimulant N/A OmniPath
TGFBR1 SMAD2 10085140 10973958 11027280 11102446 11744690 12220225 12543979 14625308 15104092 15134444 15350225 16024789 18511908 19139564 23687300 25872870 27898060 8980228 9235954 9311995 9346908 9346966 9525694 9892009 inhibition,stimulant N/A OmniPath
TGFBR1 EEF1A1 20832312 27898060 inhibition N/A OmniPath
TGFBR1 HIPK2 17729308 27898060 stimulant N/A OmniPath
TGFBR1 CDC42 19114990 27898060 stimulant N/A OmniPath
SQSTM1 TGFBR1 15761153 27898060 N/A N/A OmniPath
TAB1 TGFBR1 18316610 27898060 N/A N/A OmniPath
DAB2 TGFBR1 11387212 27898060 stimulant N/A OmniPath
TGFBR1 TGFBR3 12809600 22427868 27898060 inhibition N/A OmniPath
DACT2 TGFBR1 17197390 27898060 inhibition N/A OmniPath
TGFBR1 SMAD3 12543979 15104092 19458083 19701891 19758997 25872870 27898060 9311995 inhibition,stimulant N/A OmniPath
WWP1 TGFBR1 15221015 27898060 inhibition N/A OmniPath
ZFYVE9 TGFBR1 12052882 27898060 9865696 inhibition,stimulant N/A OmniPath
TGFBR1 ZFYVE9 27898060 9865696 stimulant N/A OmniPath
SMAD7 TGFBR1 10757800 11163210 12151385 14657019 14722617 15148321 15359284 15946939 16027725 17314099 19758997 20663871 21791611 22624557 23027871 25149540 27898060 9215638 9335507 9738003 9892110 inhibition,stimulant N/A OmniPath
TGFBR1 EIF3I 27898060 9813058 stimulant N/A OmniPath
ZFYVE16 TGFBR1 17272273 27898060 N/A N/A OmniPath
TGFBR1 TGFBRAP1 11278302 27898060 9545258 N/A N/A OmniPath
TGFBR1 ENG 12015308 15702480 16785228 18974388 27898060 9872992 stimulant N/A OmniPath
MAP3K20 TGFBR1 15465036 27898060 N/A N/A OmniPath
BAMBI TGFBR1 10519551 19758997 27898060 inhibition,stimulant N/A OmniPath
TGFB3 TGFBR1 10187774 11850637 12060054 12607775 18243111 27898060 N/A N/A OmniPath
SMURF2 TGFBR1 11163210 14722617 17317136 17347560 20386537 21791611 22624557 23973329 25149540 26679521 27898060 inhibition N/A OmniPath
TGFB2 TGFBR1 10187774 11157754 22326956 27898060 stimulant N/A OmniPath
SMAD6 TGFBR1 20663871 27898060 9335505 9436979 9892110 inhibition,stimulant N/A OmniPath
SMURF1 TGFBR1 11278251 12519765 12857866 14657019 17317136 27898060 inhibition,stimulant N/A OmniPath
PPP1CC TGFBR1 14718519 27898060 inhibition,stimulant N/A OmniPath
TGFBR1 STK17B 23122956 27898060 N/A N/A OmniPath
TGFBR1 MAP4K1 10224067 27898060 stimulant N/A OmniPath
TGFBR1 PARD6A 15761153 19114990 27898060 stimulant N/A OmniPath
TGFBR1 ACVRL1 14580334 18333754 27898060 stimulant N/A OmniPath
TGFBR1 PIK3CG 15657037 27898060 stimulant N/A OmniPath
PPP2R2A TGFBR1 27898060 9774674 stimulant N/A OmniPath
PPP2R5A TGFBR1 27898060 9774674 stimulant N/A OmniPath
TGFBR1 SPTBN1 12543979 27898060 stimulant N/A OmniPath

Visualization










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