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GENE：EGLN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EGLN2
FullNmae egl-9 family hypoxia inducible factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14660
EnsembleID ENSG00000269858
Uniprot Q96KS0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EGLN2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EGLN2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EGLN2 GO:0001558,GO:0001666,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0008198,GO:0008198,GO:0008198,GO:0016706,GO:0018401,GO:0018401,GO:0019826,GO:0030520,GO:0031418,GO:0031545,GO:0031545,GO:0043523,GO:0045454,GO:0045732,GO:0071456

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EGLN2 hsa:112398 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
EGLN2 hsa:112398 path:hsa05200 Pathways in cancer - Homo sapiens (human)
EGLN2 hsa:112398 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HIF1A EGLN2 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 23180781 24006507 24145445 25043024 25103413 25732824 26192618 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
EGLN3 EGLN2 20028863 26192618 interaction type N/A ACSN
EGLN2 EGLN3 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
EGLN1 EGLN2 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
EGLN2 UBE2V1 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
EGLN2 EGLN1 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
ARNT EGLN2 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR EGLN2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 EGLN2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 EGLN2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 EGLN2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 EGLN2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 EGLN2 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA EGLN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EGLN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EGLN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 EGLN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EGLN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 EGLN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EGLN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF EGLN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR EGLN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ARNT EGLN2 15178343 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000016914 EGLN2 22859986 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000204177 EGLN2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA EGLN2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GSK3B EGLN2 22135298 phosphorylation N/A PhosphoSite
CDK2 EGLN2 22135298 phosphorylation N/A PhosphoSite
CDK4 EGLN2 22135298 phosphorylation N/A PhosphoSite
CDK6 EGLN2 22135298 phosphorylation N/A PhosphoSite
PRKCA EGLN2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SPRY2 EGLN2 25348397 N/A physical interaction ComPPI
EGLN3 EGLN2 25348397 N/A physical interaction ComPPI
SIAH2 EGLN2 25348397 N/A physical interaction ComPPI
FBXW7 EGLN2 25348397 N/A physical interaction ComPPI
HIF1A EGLN2 11292861 11292862 14525934 15474027 16511565 17353276 24234451 25348397 hydroxylation reaction,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CUL3 EGLN2 25348397 N/A physical interaction ComPPI
TRIP6 EGLN2 25348397 N/A physical interaction ComPPI
DYRK1B EGLN2 25348397 N/A physical interaction ComPPI
VHL EGLN2 25348397 N/A two hybrid ComPPI
TENT5A EGLN2 14525934 15231748 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
POLR2A EGLN2 25348397 N/A physical interaction ComPPI
AJUBA EGLN2 25348397 N/A physical interaction ComPPI
HIF3A EGLN2 14525934 15474027 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
LPP EGLN2 25348397 N/A physical interaction ComPPI
TRIM25 EGLN2 25348397 N/A physical interaction ComPPI
SPOP EGLN2 25348397 N/A physical interaction ComPPI
SRPK2 EGLN2 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
MOB4 EGLN2 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EPAS1 EGLN2 14525934 15474027 17353276 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
EGLN2 PRPF19 25348397 N/A physical interaction ComPPI
EGLN2 LIMD1 25348397 N/A physical interaction ComPPI
EGLN2 WTIP 25348397 N/A physical interaction ComPPI
EGLN2 MAGEA11 25348397 N/A physical interaction ComPPI
EGLN2 A2M 25348397 N/A physical interaction ComPPI
EGLN2 CEP192 25348397 N/A physical interaction ComPPI
EGLN2 DYRK1A 25348397 N/A physical interaction ComPPI
EGLN2 MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
PRKCA EGLN2 18710826 27898060 inhibition N/A OmniPath
HIF1A EGLN2 11292861 11292862 15474027 16511565 17353276 18264140 24145445 27898060 N/A N/A OmniPath
EGLN2 HIF1A 11292861 11292862 15474027 16391536 16511565 17353276 18264140 24145445 27898060 inhibition,stimulant N/A OmniPath

Visualization










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