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GENE：POLD2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLD2
FullNmae DNA polymerase delta 2, accessory subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9176
EnsembleID ENSG00000106628
Uniprot P49005

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLD2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLD2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
POLD2 GO:0003677,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006260,GO:0006261,GO:0006271,GO:0016035,GO:0016035,GO:0042276,GO:0043625,GO:0043625,GO:0043625,GO:0071897

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLD2 hsa:5425 path:hsa03030 DNA replication - Homo sapiens (human)
POLD2 hsa:5425 path:hsa03410 Base excision repair - Homo sapiens (human)
POLD2 hsa:5425 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
POLD2 hsa:5425 path:hsa03430 Mismatch repair - Homo sapiens (human)
POLD2 hsa:5425 path:hsa03440 Homologous recombination - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 POLD2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 POLD2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC POLD2 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP53 POLD2 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 POLD2 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP63 POLD2 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 POLD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 POLD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 POLD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS POLD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF POLD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 POLD2 10978529 trascriptional regulation,stimulation inferred by curator TFlink
JUN POLD2 10978529 trascriptional regulation,stimulation inferred by curator TFlink
NFIC POLD2 10978529 trascriptional regulation,stimulation inferred by curator TFlink
SP1 POLD2 10978529 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 POLD2 10978529 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A POLD2 10978529 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 POLD2 N/A rna interference,inhibition experimental interaction detection miRSponge
URS0000324096 POLD2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS0000153377 POLD2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K7 POLD2 22135298 phosphorylation N/A PhosphoSite
FEN1 POLD2 25361965 interaction type N/A PTMCode2
POLD2 FEN1 25361965 interaction type N/A PTMCode2
WRNIP1 POLD2 25361965 interaction type N/A PTMCode2
POLD2 WRNIP1 25361965 interaction type N/A PTMCode2
POLA1 POLD2 25361965 interaction type N/A PTMCode2
POLD2 POLA1 25361965 interaction type N/A PTMCode2
WRN POLD2 25361965 interaction type N/A PTMCode2
POLD2 WRN 25361965 interaction type N/A PTMCode2
POLD4 POLD2 25361965 interaction type N/A PTMCode2
POLD2 POLD4 25361965 interaction type N/A PTMCode2
PCNA POLD2 25361965 interaction type N/A PTMCode2
POLD2 PCNA 25361965 interaction type N/A PTMCode2
POLD3 POLD2 25361965 interaction type N/A PTMCode2
POLD2 POLD3 25361965 interaction type N/A PTMCode2
POLD1 POLD2 25361965 interaction type N/A PTMCode2
POLD2 POLD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PCNA POLD2 16000169 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
CDKN1A POLD2 25348397 N/A two hybrid ComPPI
LSM6 POLD2 15231747 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KCTD13 POLD2 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
ERBB2 POLD2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EP300 POLD2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
WRN POLD2 11027336 19969545 25348397 27898060 N/A in vitro ComPPI,OmniPath
POLH POLD2 25348397 25662213 27898060 N/A physical interaction ComPPI,OmniPath
POLD3 POLD2 16000169 16510448 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,pull down,physical interaction,in vivo ComPPI,IntAct
POLD2 WRNIP1 15670210 24234451 25348397 association,physical association anti tag coimmunoprecipitation,in vitro ComPPI,IntAct
POLD2 POLD1 12403614 16510448 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,molecular sieving,chromatography technology,pull down,physical interaction,ion exchange chromatography ComPPI,IntAct
POLD2 POLDIP3 25348397 N/A two hybrid ComPPI
POLD2 CDK2 25348397 N/A in vitro ComPPI
POLD2 MMS19 25348397 N/A physical interaction ComPPI
POLD2 POLD4 16510448 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
POLD2 CCHCR1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
POLD2 SOX12 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
POLD2 XRN1 25348397 N/A physical interaction ComPPI
POLD2 AP5Z1 25348397 N/A physical interaction ComPPI
POLD2 FOXK1 25348397 N/A physical interaction ComPPI
POLD2 SPRTN 25348397 N/A physical interaction ComPPI
POLD2 SIRT6 25348397 N/A physical interaction ComPPI
POLD2 OSBPL9 25348397 N/A physical interaction ComPPI
POLD2 POLA2 25348397 N/A physical interaction ComPPI
POLD2 XPO1 25348397 N/A physical interaction ComPPI
POLD2 REV3L 25348397 N/A physical interaction ComPPI
POLD2 AMZ1 25348397 N/A physical interaction ComPPI
POLD2 PPP5C 25348397 N/A physical interaction ComPPI
POLD2 DKKL1 25348397 N/A physical interaction ComPPI
POLD2 ERP44 25348397 N/A physical interaction ComPPI
POLD2 GPR37 25348397 N/A physical interaction ComPPI
POLD2 P4HA2 25348397 N/A physical interaction ComPPI
POLD2 NAB2 25348397 N/A physical interaction ComPPI
POLD2 TRIM25 25348397 N/A physical interaction ComPPI
POLD2 TSG101 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
POLDIP2 POLD2 25348397 N/A two hybrid,in vitro,in vivo ComPPI
H3C1 POLD2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HSCB POLD2 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
NIBAN1 POLD2 25348397 N/A physical interaction ComPPI

Visualization










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