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GENE：LIG3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LIG3
FullNmae DNA ligase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6600
EnsembleID ENSG00000005156
Uniprot P49916

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LIG3 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LIG3 GO:0000724,GO:0003677,GO:0003909,GO:0003909,GO:0003910,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005739,GO:0006273,GO:0006287,GO:0006288,GO:0006288,GO:0006288,GO:0006302,GO:0006302,GO:0007049,GO:0008270,GO:0051301,GO:0070421,GO:0071897,GO:0090298

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LIG3 hsa:3980 path:hsa03410 Base excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PLCG1 LIG3 17474147 23180781 physical association peptide array InnateDB
EED LIG3 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 LIG3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 LIG3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LIG3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LIG3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LIG3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LIG3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LIG3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LIG3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LIG3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 LIG3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 LIG3 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001C770D LIG3 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 LIG3 22135298 phosphorylation N/A PhosphoSite
CDK2 LIG3 22135298 phosphorylation N/A PhosphoSite
XRCC1 LIG3 25361965 interaction type N/A PTMCode2
LIG3 XRCC1 25361965 interaction type N/A PTMCode2
TDP1 LIG3 25361965 interaction type N/A PTMCode2
LIG3 TDP1 25361965 interaction type N/A PTMCode2
NEIL1 LIG3 25361965 interaction type N/A PTMCode2
LIG3 NEIL1 25361965 interaction type N/A PTMCode2
PNKP LIG3 25361965 interaction type N/A PTMCode2
LIG3 PNKP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CBX8 LIG3 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
POLB LIG3 25348397 N/A physical interaction ComPPI
LMNA LIG3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FOXB1 LIG3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PTPRH LIG3 24234451 25348397 28330616 association pull down ComPPI,IntAct
H2BC4 LIG3 25348397 N/A physical interaction ComPPI
CRK LIG3 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
AIM2 LIG3 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
APLF LIG3 17396150 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
EMC2 LIG3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NF2 LIG3 25348397 N/A physical interaction ComPPI
RACGAP1 LIG3 25348397 N/A physical interaction ComPPI
PIK3R1 LIG3 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
SRC LIG3 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NFATC1 LIG3 25348397 N/A physical interaction ComPPI
JUN LIG3 24234451 25348397 25609649 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PNKP LIG3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
THRA LIG3 25348397 N/A physical interaction ComPPI
THRB LIG3 25348397 N/A physical interaction ComPPI
NTRK1 LIG3 25348397 N/A physical interaction ComPPI
PARP1 LIG3 12897160 14525934 24234451 24778456 25348397 association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
XRCC1 LIG3 11163244 14525934 17353931 24234451 25348397 26496610 8264637 9136882 9705932 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
APTX LIG3 25348397 N/A physical interaction ComPPI
XRCC5 LIG3 25348397 N/A physical interaction ComPPI
RPA1 LIG3 25348397 N/A physical interaction ComPPI
XRCC6 LIG3 25348397 N/A physical interaction ComPPI
NFATC2 LIG3 25348397 N/A physical interaction ComPPI
RPA2 LIG3 25348397 N/A physical interaction ComPPI
RPA3 LIG3 25348397 N/A physical interaction ComPPI
TMPO LIG3 25348397 N/A physical interaction ComPPI
MACROD1 LIG3 25348397 N/A physical interaction ComPPI
MDC1 LIG3 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
EED LIG3 25348397 N/A physical interaction ComPPI
LIG3 JTB 12897160 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
LIG3 NEIL1 25348397 N/A physical interaction ComPPI
LIG3 NCAPG 25348397 N/A physical interaction ComPPI
LIG3 NBN 25348397 N/A physical interaction ComPPI
LIG3 APP 25348397 N/A physical interaction ComPPI
LIG3 MOV10 25348397 N/A physical interaction ComPPI
LIG3 NXF1 25348397 N/A physical interaction ComPPI
LIG3 PYCARD 24234451 24407287 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LIG3 CCDC8 25348397 N/A physical interaction ComPPI
LIG3 TOP3A 25348397 N/A physical interaction ComPPI
LIG3 PREPL 25348397 N/A physical interaction ComPPI
LIG3 JMJD4 25348397 N/A physical interaction ComPPI
LIG3 CLPX 25348397 N/A physical interaction ComPPI
LIG3 RSAD1 25348397 N/A physical interaction ComPPI
LIG3 FMC1 25348397 N/A physical interaction ComPPI
LIG3 PSME3 25348397 N/A physical interaction ComPPI
LIG3 NDUFS6 25348397 N/A physical interaction ComPPI
LIG3 RNF146 25348397 N/A physical interaction ComPPI
LIG3 H2BC1 25348397 N/A physical interaction ComPPI
LIG3 KIF23 25348397 N/A physical interaction ComPPI
LIG3 H2BC11 25348397 N/A physical interaction ComPPI
LIG3 BAX 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIG3 TMPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIG3 EXOSC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIG3 MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIG3 SPC24 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIG3 MAX 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
LIG3 FOXD3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
LIG3 FOXE1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
LIG3 FOXK2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
LIG3 FOXP1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
LIG3 H2AX 25348397 N/A physical interaction ComPPI
LIG3 RNF166 25348397 N/A physical interaction ComPPI
LIG3 WDR76 25348397 N/A physical interaction ComPPI
LIG3 LARS2 25348397 N/A physical interaction ComPPI
LIG3 CRBN 25348397 N/A physical interaction ComPPI
LIG3 TDP1 14525934 15744309 20009512 25348397 27898060 N/A physical interaction,two hybrid ComPPI,HPRD,OmniPath
LIG3 ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
LIG3 PLCG1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
LIG3 PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
H3C1 LIG3 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HSPA5 LIG3 24234451 30021884 physical association cross-linking study IntAct
HSP90B1 LIG3 24234451 30021884 physical association cross-linking study IntAct
TOP1 LIG3 13679147 27898060 inhibition N/A OmniPath
CDK2 LIG3 17040896 27898060 inhibition N/A OmniPath
CDK1 LIG3 17040896 27898060 N/A N/A OmniPath

Visualization










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