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GENE：PRKDC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKDC
FullNmae protein kinase, DNA-activated, catalytic subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9413
EnsembleID ENSG00000253729
Uniprot P78527

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKDC parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKDC necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKDC mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKDC apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKDC apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
PRKDC cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PRKDC GO:0000460,GO:0000723,GO:0000781,GO:0000785,GO:0001756,GO:0001933,GO:0002218,GO:0002326,GO:0002327,GO:0002328,GO:0002360,GO:0003690,GO:0003723,GO:0004672,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004677,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0005958,GO:0006302,GO:0006302,GO:0006303,GO:0006303,GO:0006468,GO:0006468,GO:0006468,GO:0006974,GO:0007420,GO:0007507,GO:0008630,GO:0010332,GO:0016020,GO:0016233,GO:0018105,GO:0018107,GO:0019899,GO:0019904,GO:0031571,GO:0031648,GO:0032040,GO:0032869,GO:0032991,GO:0032993,GO:0033077,GO:0033152,GO:0033153,GO:0034462,GO:0034511,GO:0035234,GO:0036211,GO:0042752,GO:0043065,GO:0043066,GO:0045087,GO:0045621,GO:0045648,GO:0045727,GO:0045824,GO:0045944,GO:0048511,GO:0048660,GO:0050678,GO:0061629,GO:0070418,GO:0070419,GO:0097681,GO:0106310,GO:1902036,GO:1905221,GO:2001034

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKDC hsa:5591 path:hsa03450 Non-homologous end-joining - Homo sapiens (human)
PRKDC hsa:5591 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDK2 PRKDC 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB
XRCC5 PRKDC 23180781 24098118 physical association anti tag coimmunoprecipitation InnateDB
EED PRKDC 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
MECOM PRKDC 23180781 23858473 physical association anti tag coimmunoprecipitation InnateDB
PRKDC CIB1 15190070 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
MYC PRKDC 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PRKDC 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PRKDC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRKDC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PRKDC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRKDC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRKDC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PRKDC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PRKDC N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PRKDC PRKDC 22135298 phosphorylation N/A PhosphoSite
PRKDC POU2F1 22135298 phosphorylation N/A PhosphoSite
PRKDC XRCC6 22135298 phosphorylation N/A PhosphoSite
PRKDC DCLRE1C 22135298 phosphorylation N/A PhosphoSite
PRKDC IRF3 22135298 phosphorylation N/A PhosphoSite
PRKDC XRCC4 22135298 phosphorylation N/A PhosphoSite
PRKDC WRN 22135298 phosphorylation N/A PhosphoSite
PRKDC TP53 22135298 phosphorylation N/A PhosphoSite
PRKDC POLL 22135298 phosphorylation N/A PhosphoSite
PRKDC XPA 22135298 phosphorylation N/A PhosphoSite
PRKDC FUS 22135298 phosphorylation N/A PhosphoSite
PRKDC IGFBP3 22135298 phosphorylation N/A PhosphoSite
PRKDC NHEJ1 22135298 phosphorylation N/A PhosphoSite
PRKDC H1-2 22135298 phosphorylation N/A PhosphoSite
PRKDC HSP90AA1 22135298 phosphorylation N/A PhosphoSite
PRKDC XRCC5 22135298 phosphorylation N/A PhosphoSite
PRKDC CDKN1B 22135298 phosphorylation N/A PhosphoSite
PRKDC H2AX 22135298 phosphorylation N/A PhosphoSite
PRKDC NFKB1 22135298 phosphorylation N/A PhosphoSite
PRKDC HNRNPU 22135298 phosphorylation N/A PhosphoSite
PRKDC RPA2 22135298 phosphorylation N/A PhosphoSite
PRKDC POLR2A 22135298 phosphorylation N/A PhosphoSite
PRKDC MED1 22135298 phosphorylation N/A PhosphoSite
PRKDC FH 22135298 phosphorylation N/A PhosphoSite
PRKDC AIRE 22135298 phosphorylation N/A PhosphoSite
PRKDC HOXA11 22135298 phosphorylation N/A PhosphoSite
PRKDC SRF 22135298 phosphorylation N/A PhosphoSite
PRKDC AKT1 22135298 phosphorylation N/A PhosphoSite
PRKDC GOLPH3 22135298 phosphorylation N/A PhosphoSite
PRKDC CHEK2 22135298 phosphorylation N/A PhosphoSite
PRKDC CASP2 22135298 phosphorylation N/A PhosphoSite
PRKDC LIG4 22135298 phosphorylation N/A PhosphoSite
PRKDC VIM 22135298 phosphorylation N/A PhosphoSite
PRKDC XRCC1 22135298 phosphorylation N/A PhosphoSite
PRKDC TDP1 22135298 phosphorylation N/A PhosphoSite
PRKDC USF1 22135298 phosphorylation N/A PhosphoSite
PRKDC RAG2 22135298 phosphorylation N/A PhosphoSite
PRKDC VCP 22135298 phosphorylation N/A PhosphoSite
PRKDC PDX1 22135298 phosphorylation N/A PhosphoSite
PRKDC PNPT1 22135298 phosphorylation N/A PhosphoSite
ATR PRKDC 22135298 phosphorylation N/A PhosphoSite
ATM PRKDC 22135298 phosphorylation N/A PhosphoSite
AURKB PRKDC 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
UBE2I PRKDC 25348397 N/A physical interaction ComPPI
SNW1 PRKDC 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC73 PRKDC 25348397 N/A physical interaction ComPPI
CUL5 PRKDC 25348397 N/A physical interaction ComPPI
CDC5L PRKDC 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SNRPA PRKDC 25348397 N/A physical interaction ComPPI
MAPK9 PRKDC 25348397 N/A physical interaction ComPPI
HNRNPC PRKDC 25348397 N/A physical interaction ComPPI
HSPA8 PRKDC 25348397 N/A physical interaction ComPPI
BAG3 PRKDC 25348397 N/A physical interaction ComPPI
ISG15 PRKDC 24234451 25348397 26259872 association pull down ComPPI,IntAct
RARA PRKDC 24234451 25303530 25348397 27898060 association,physical association pull down ComPPI,IntAct,OmniPath
HOXC4 PRKDC 11279128 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PCNA PRKDC 12171929 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EMD PRKDC 25348397 N/A physical interaction ComPPI
LMNA PRKDC 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
GABARAPL2 PRKDC 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
YWHAG PRKDC 14525934 15324660 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
BMI1 PRKDC 25348397 N/A physical interaction ComPPI
NR5A1 PRKDC 24234451 24635384 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RAD21 PRKDC 25348397 N/A physical interaction ComPPI
KEAP1 PRKDC 25348397 N/A physical interaction ComPPI
MCM2 PRKDC 25348397 N/A physical interaction ComPPI
MAP1LC3B PRKDC 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSP90AB1 PRKDC 16263121 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
APLF PRKDC 17396150 24234451 25348397 association pull down ComPPI,IntAct
SP1 PRKDC 14525934 25348397 8422676 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK8 PRKDC 11749722 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LYN PRKDC 14525934 25348397 9748231 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CD81 PRKDC 24234451 25348397 26212323 association anti bait coimmunoprecipitation ComPPI,IntAct
NOTCH1 PRKDC 23022380 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
SHC1 PRKDC 25348397 N/A physical interaction ComPPI
SPI1 PRKDC 21575865 24234451 25348397 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
ETV1 PRKDC 21575865 24234451 25348397 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
PRKCD PRKDC 14525934 25348397 9774685 N/A anti tag coimmunoprecipitation,experimental interaction detection,in vitro ComPPI,HPRD
CASP3 PRKDC 14525934 25348397 8804412 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKDC JUN 14525934 24234451 25348397 25609649 8464713 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
PRKDC PARP1 14525934 20085707 21575865 24234451 25348397 9398855 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PRKDC RPA2 10064605 11731442 14525934 25348397 9295339 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKDC SRF 14525934 25348397 8407951 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKDC CHUK 14525934 25348397 9632806 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKDC EIF2S2 14525934 25348397 9442054 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKDC WRN 11889123 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKDC NCOA6 12519782 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKDC ATM 10464290 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKDC XRCC5 10207052 10446239 14525934 17308091 19303849 20023628 20085707 20711232 24234451 25348397 26496610 9312071 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,protein kinase assay,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
PRKDC NBN 14525934 15758953 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKDC TREX1 25348397 N/A in vivo ComPPI
PRKDC DCLRE1C 11955432 14525934 15936993 22529269 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRKDC AKT1 14525934 15262962 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKDC CIB1 14525934 15190070 25348397 9372844 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKDC USF1 14525934 19303849 24234451 25348397 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,in vitro ComPPI,HPRD,IntAct
PRKDC NR3C1 14525934 25348397 9038175 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKDC HSP90AA1 14525934 2507541 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKDC HSF1 14525934 25348397 9325337 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKDC XRCC6 10446239 11279128 14525934 17308091 19303849 20711232 21575865 24234451 25348397 26175416 26496610 9312071 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
PRKDC AR 24234451 25348397 26175416 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC AP1B1 25348397 N/A physical interaction ComPPI
PRKDC BRCA1 25348397 N/A physical interaction ComPPI
PRKDC CHEK1 25348397 N/A physical interaction ComPPI
PRKDC E4F1 25348397 N/A physical interaction ComPPI
PRKDC MRE11 25348397 N/A physical interaction ComPPI
PRKDC RAD17 25348397 N/A physical interaction ComPPI
PRKDC RBBP8 25348397 N/A physical interaction ComPPI
PRKDC TP53 10470151 10673501 10747897 10951572 11551930 11709713 11883897 14525934 25348397 9765199 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKDC KAT2A 25348397 N/A physical interaction ComPPI
PRKDC ABL1 14525934 25348397 9312071 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKDC IKBKB 25348397 N/A physical interaction ComPPI
PRKDC AKT2 25348397 N/A physical interaction ComPPI
PRKDC ILF3 25348397 N/A physical interaction ComPPI
PRKDC NCF1B 25348397 N/A physical interaction ComPPI
PRKDC NCF1 25348397 N/A physical interaction ComPPI
PRKDC NCF2 25348397 N/A physical interaction ComPPI
PRKDC NCF4 25348397 N/A physical interaction ComPPI
PRKDC HDLBP 25348397 N/A physical interaction ComPPI
PRKDC RECQL5 25348397 N/A physical interaction ComPPI
PRKDC MLH1 25348397 N/A physical interaction ComPPI
PRKDC PMS2 25348397 N/A physical interaction ComPPI
PRKDC PMS2CL 25348397 N/A physical interaction ComPPI
PRKDC SIRT6 25348397 N/A physical interaction ComPPI
PRKDC AIRE 20085707 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC TTI1 20371770 20810650 24234451 25348397 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PRKDC TELO2 18160036 20801936 24234451 25348397 association affinity chromatography technology,anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PRKDC ATG4C 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC BECN1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC ATG101 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC CAMKK2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC NIPSNAP2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC PRKAB2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC POU2F1 25348397 N/A physical interaction ComPPI
PRKDC MKNK1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PRKDC NR1H4 25348397 N/A physical interaction ComPPI
PRKDC CHD1L 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
PRKDC ESR1 21182205 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
PRKDC KAT5 25348397 N/A physical interaction ComPPI
PRKDC TTI2 20801936 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKDC SAP25 25348397 N/A physical interaction ComPPI
PRKDC H2AX 20085707 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC MGMT 25348397 N/A physical interaction ComPPI
PRKDC PDX1 25348397 N/A physical interaction ComPPI
PRKDC AICDA 15634916 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKDC DHX9 25348397 N/A physical interaction ComPPI
PRKDC H1-2 25348397 N/A physical interaction ComPPI
PRKDC XRCC4 14525934 25348397 9430729 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKDC YY1 18026119 24234451 25348397 association,physical association cosedimentation through density gradient,pull down,physical interaction ComPPI,IntAct
PRKDC KAT8 25348397 N/A physical interaction ComPPI
PRKDC MSL3 25348397 N/A physical interaction ComPPI
PRKDC THRA 25348397 N/A physical interaction ComPPI
PRKDC THRB 25348397 N/A physical interaction ComPPI
PRKDC HDAC3 25348397 N/A physical interaction ComPPI
PRKDC BIRC5 25348397 N/A physical interaction ComPPI
PRKDC H1-1 25348397 N/A physical interaction ComPPI
PRKDC PPP2CA 25348397 N/A physical interaction ComPPI
PRKDC PPP6C 24234451 24255178 25348397 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PRKDC PPP6R1 25348397 N/A physical interaction ComPPI
PRKDC PPP6R2 25348397 N/A physical interaction ComPPI
PRKDC PPP6R3 25348397 N/A physical interaction ComPPI
PRKDC MYC 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKDC RYK 25348397 N/A physical interaction ComPPI
PRKDC HDAC5 25348397 N/A physical interaction ComPPI
PRKDC PIDD1 25348397 N/A physical interaction ComPPI
PRKDC SMARCAD1 25348397 N/A physical interaction ComPPI
PRKDC ATRIP 14525934 15758953 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKDC HDGF 21907836 24234451 25348397 association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
PRKDC CTDP1 21450944 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKDC CENPA 25348397 N/A physical interaction,physical interaction,tandem affinity purification ComPPI
PRKDC MSH6 25348397 N/A physical interaction ComPPI
PRKDC TERF1 25348397 N/A physical interaction ComPPI
PRKDC MDC1 25348397 N/A physical interaction ComPPI
PRKDC ELAVL1 25348397 N/A physical interaction ComPPI
PRKDC SIRT7 25348397 N/A physical interaction ComPPI
PRKDC CSNK2A1 25348397 N/A physical interaction ComPPI
PRKDC HNRNPA1 25348397 N/A physical interaction ComPPI
PRKDC ERG 21575865 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction,chromatin immunoprecipitation assay ComPPI,IntAct
PRKDC PINK1 25348397 N/A physical interaction ComPPI
PRKDC CUL3 25348397 N/A physical interaction ComPPI
PRKDC CDK2 25348397 N/A physical interaction ComPPI
PRKDC COPS5 25348397 N/A physical interaction ComPPI
PRKDC ARHGEF6 25348397 N/A physical interaction ComPPI
PRKDC DCAF1 25348397 N/A physical interaction ComPPI
PRKDC LRRK2 17400507 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC MBP 25348397 N/A physical interaction ComPPI
PRKDC GRK5 25348397 N/A physical interaction ComPPI
PRKDC AP2M1 25348397 N/A physical interaction ComPPI
PRKDC UBXN6 25348397 N/A physical interaction ComPPI
PRKDC EFTUD2 25348397 N/A physical interaction ComPPI
PRKDC DDX5 25348397 N/A physical interaction ComPPI
PRKDC PRPF8 25348397 N/A physical interaction ComPPI
PRKDC SF3B6 25348397 N/A physical interaction ComPPI
PRKDC CWC27 25348397 N/A physical interaction ComPPI
PRKDC THOC6 25348397 N/A physical interaction ComPPI
PRKDC YBX1 25348397 N/A physical interaction ComPPI
PRKDC TRA2B 25348397 N/A physical interaction ComPPI
PRKDC U2AF2 25348397 N/A physical interaction ComPPI
PRKDC RBM25 25348397 N/A physical interaction ComPPI
PRKDC DHX38 25348397 N/A physical interaction ComPPI
PRKDC SRP14 25348397 N/A physical interaction ComPPI
PRKDC RPS11 25348397 N/A physical interaction ComPPI
PRKDC SMARCA5 25348397 N/A physical interaction ComPPI
PRKDC SRSF10 25348397 N/A physical interaction ComPPI
PRKDC SRP54 25348397 N/A physical interaction ComPPI
PRKDC PHGDH 25348397 N/A physical interaction ComPPI
PRKDC RANBP2 25348397 N/A physical interaction ComPPI
PRKDC PTER 25348397 N/A physical interaction ComPPI
PRKDC THYN1 25348397 N/A physical interaction ComPPI
PRKDC TPR 25348397 N/A physical interaction ComPPI
PRKDC PGR 25348397 N/A physical interaction ComPPI
PRKDC ELP1 25348397 N/A physical interaction ComPPI
PRKDC PNKP 25348397 N/A physical interaction ComPPI
PRKDC GSK3A 25348397 N/A physical interaction ComPPI
PRKDC GSK3B 25348397 N/A physical interaction ComPPI
PRKDC HSP90AA2P 25348397 N/A physical interaction ComPPI
PRKDC FN1 25348397 N/A physical interaction ComPPI
PRKDC VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PRKDC GZMB 14525934 25348397 9586635 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKDC NOS2 25348397 N/A physical interaction ComPPI
PRKDC ITGA4 25348397 N/A physical interaction ComPPI
PRKDC CFTR 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC CHEK2 25348397 N/A physical interaction ComPPI
PRKDC PAN2 25348397 N/A physical interaction ComPPI
PRKDC RUVBL1 20371770 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
PRKDC HDAC11 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC ADRB2 25348397 N/A physical interaction ComPPI
PRKDC EGFR 23178489 24234451 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
PRKDC IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC FBXO6 25348397 N/A physical interaction ComPPI
PRKDC GTF2I 25348397 N/A physical interaction ComPPI
PRKDC PRDX1 25348397 N/A physical interaction ComPPI
PRKDC RTCB 25348397 N/A physical interaction ComPPI
PRKDC EHD1 25348397 N/A physical interaction ComPPI
PRKDC FLII 25348397 N/A physical interaction ComPPI
PRKDC LRRFIP1 25348397 N/A physical interaction ComPPI
PRKDC METTL1 25348397 N/A physical interaction ComPPI
PRKDC RFC2 25348397 N/A physical interaction ComPPI
PRKDC RPA3 25348397 N/A physical interaction ComPPI
PRKDC LGR4 25348397 N/A physical interaction ComPPI
PRKDC PHKG2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKDC ILK 23455922 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PRKDC ATRX 25348397 N/A physical interaction ComPPI
PRKDC STAU1 25348397 N/A physical interaction ComPPI
PRKDC RELA 25348397 N/A physical interaction,tandem affinity purification ComPPI
PRKDC RNF144A 25348397 N/A physical interaction ComPPI
PRKDC CUL7 25348397 N/A physical interaction ComPPI
PRKDC OBSL1 25348397 N/A physical interaction ComPPI
PRKDC CCDC8 25348397 N/A physical interaction ComPPI
PRKDC EED 25348397 N/A physical interaction ComPPI
PRKDC AUP1 25348397 N/A physical interaction ComPPI
PRKDC FOXRED2 25348397 N/A physical interaction ComPPI
PRKDC UBAC2 25348397 N/A physical interaction ComPPI
PRKDC FAF2 25348397 N/A physical interaction ComPPI
PRKDC SUMO2 25348397 N/A physical interaction ComPPI
PRKDC EP300 20808282 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC RASSF1 25348397 N/A physical interaction ComPPI
PRKDC NTRK1 25348397 N/A physical interaction ComPPI
PRKDC NUP85 25348397 N/A physical interaction ComPPI
PRKDC NUP107 25348397 N/A physical interaction ComPPI
PRKDC NUP35 25348397 N/A physical interaction ComPPI
PRKDC CLK1 25348397 N/A physical interaction ComPPI
PRKDC HSPA5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC DNAJC7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC POT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC TINF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC DCLRE1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC SKI 25348397 N/A physical interaction ComPPI
PRKDC CRY1 25348397 N/A physical interaction ComPPI
PRKDC CRY2 25348397 N/A physical interaction ComPPI
PRKDC ANAPC2 25348397 N/A physical interaction ComPPI
PRKDC FZR1 25348397 N/A physical interaction ComPPI
PRKDC CCNB1 25348397 26221070 27898060 N/A physical interaction ComPPI,OmniPath
PRKDC MEX3C 25348397 N/A physical interaction ComPPI
PRKDC POU5F1 25348397 N/A physical interaction ComPPI
PRKDC ALOX15 25348397 N/A physical interaction ComPPI
PRKDC NFATC2 25348397 N/A physical interaction ComPPI
PRKDC AHSA1 25348397 N/A physical interaction ComPPI
PRKDC XRCC1 25348397 N/A physical interaction ComPPI
PRKDC ATOH1 25348397 N/A physical interaction ComPPI
PRKDC AKTIP 25348397 N/A physical interaction ComPPI
PRKDC ZNF746 25348397 N/A physical interaction ComPPI
PRKDC EPHA1 25348397 N/A physical interaction ComPPI
PRKDC LPAR4 25348397 N/A physical interaction ComPPI
PRKDC MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
PRKDC CYLD 25348397 N/A physical interaction ComPPI
PRKDC TRIM25 25348397 N/A physical interaction ComPPI
PRKDC TES 25348397 N/A physical interaction ComPPI
PRKDC MTF1 25348397 N/A physical interaction ComPPI
PRKDC LNX1 25348397 N/A physical interaction ComPPI
PRKDC HIF1A 25348397 N/A physical interaction ComPPI
PRKDC CBFA2T2 24234451 25348397 27281218 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKDC GRB2 12577067 24234451 25348397 association pull down ComPPI,IntAct
PRKDC NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRKDC IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRKDC MAP3K3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRKDC NFKB2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRKDC RELB 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRKDC RIPK3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRKDC TNFRSF1A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRKDC TNFRSF1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRKDC TRADD 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PRKDC YWHAB 15324660 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
PRKDC TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
PRKDC YWHAZ 20618440 24234451 25348397 association pull down,tandem affinity purification ComPPI,IntAct
PRKDC ZIC2 18097573 24234451 25348397 27898060 phosphorylation reaction protein kinase assay ComPPI,IntAct,OmniPath
PRKDC TOP2A 20085707 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
PRKDC ESR2 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
PRKDC APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
PRKDC MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKDC GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKDC GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKDC ETS1 21575865 24234451 25348397 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
PRKDC CBX3 21888893 24234451 25348397 association tandem affinity purification ComPPI,IntAct
PRKDC E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
PRKDC MAPKAP1 24234451 24365180 25348397 27898060 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
PRKDC MTOR 24234451 24365180 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PRKDC IGFBP3 23178489 24234451 25348397 association,physical association anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct
PRKDC RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKDC CCNC 19047373 24234451 25348397 physical association chromatography technology ComPPI,IntAct
PRKDC MED13 19047373 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PRKDC CDK8 19047373 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PRKDC NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
PRKDC DUX4 24234451 25348397 26816005 association pull down ComPPI,IntAct
PRKDC PPEF1 24234451 25348397 28330616 association pull down ComPPI,IntAct
PRKDC RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKDC DEAF1 22442688 24234451 25348397 physical association pull down ComPPI,IntAct
LIG4 PRKDC 14525934 15194694 22529269 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
RPA1 PRKDC 10064605 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CHAF1A PRKDC 25348397 N/A physical interaction ComPPI
HMGB2 PRKDC 14525934 25348397 9722660 N/A experimental interaction detection,in vitro ComPPI,HPRD
EIF4EBP1 PRKDC 25348397 N/A physical interaction ComPPI
HMGB1 PRKDC 14525934 25348397 9722660 N/A experimental interaction detection,in vitro ComPPI,HPRD
XPA PRKDC 14525934 16540648 20304803 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
YWHAQ PRKDC 25348397 N/A physical interaction ComPPI
CSNK2A2 PRKDC 20711232 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
H3C1 PRKDC 20080577 24234451 25348397 29568061 association physical interaction,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
H3-3A PRKDC 25348397 N/A physical interaction ComPPI
NUCB1 PRKDC 25348397 N/A physical interaction ComPPI
C1D PRKDC 14525934 25348397 9679063 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ILF2 PRKDC 14525934 20808282 24234451 25348397 9442054 association affinity chromatography technology,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
HOXB7 PRKDC 17308091 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
RTRAF PRKDC 25348397 N/A physical interaction ComPPI
CTPS2 PRKDC 25348397 N/A physical interaction ComPPI
DDA1 PRKDC 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GOLPH3 PRKDC 24234451 24485452 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PRKDC PRKDC 10823961 12186630 14525934 N/A experimental interaction detection HPRD
SGO1 PRKDC 14525934 16541024 N/A experimental interaction detection HPRD
PRKDC GREB1 24234451 25303530 association chromatin immunoprecipitation assay IntAct
UGT2B17 PRKDC 24234451 26175416 association chromatin immunoprecipitation assay IntAct
ROCK2 PRKDC 24234451 26175416 association chromatin immunoprecipitation assay IntAct
PREX1 PRKDC 24234451 26175416 association chromatin immunoprecipitation assay IntAct
ITGB4 PRKDC 24234451 26175416 association chromatin immunoprecipitation assay IntAct
METTL3 PRKDC 24234451 29507755 association anti tag coimmunoprecipitation IntAct
METTL14 PRKDC 24234451 29507755 association anti tag coimmunoprecipitation IntAct
TIAM2 PRKDC 24234451 30021884 physical association cross-linking study IntAct
PRKDC PWWP2B 24234451 30021884 physical association cross-linking study IntAct
PRKDC ANXA2 24234451 30021884 physical association cross-linking study IntAct
PRKDC FAM161A 24234451 30021884 physical association cross-linking study IntAct
PRKDC SYNJ2 24234451 30021884 physical association cross-linking study IntAct
PRKDC CPN1 24234451 30021884 physical association cross-linking study IntAct
PRKDC ZNF840P 24234451 30021884 physical association cross-linking study IntAct
PRKDC NRXN1 24234451 30021884 physical association cross-linking study IntAct
PRKDC LAMC3 24234451 30021884 physical association cross-linking study IntAct
PRKDC SYNE2 24234451 30021884 physical association cross-linking study IntAct
PRKDC TBC1D28 24234451 30021884 physical association cross-linking study IntAct
PRKDC RNF8 24234451 30021884 physical association cross-linking study IntAct
PRKDC GTPBP4 24234451 30021884 physical association cross-linking study IntAct
L1TD1 PRKDC 24234451 25702638 association anti bait coimmunoprecipitation IntAct
CCNT2 PRKDC 21214942 27898060 N/A N/A OmniPath
PRKDC VCP 16140914 27898060 stimulant N/A OmniPath
EGFR PRKDC 18237807 18789131 23178489 27898060 stimulant N/A OmniPath
PRKCD PRKDC 19737086 27898060 9774685 inhibition N/A OmniPath
PRKDC POLR2A 18079403 18079404 19450536 19901026 20457598 22137580 24662513 25561469 27898060 N/A N/A OmniPath
PRKDC HNRNPU 19351595 19844162 27898060 stimulant N/A OmniPath
PRKDC CHEK2 11390408 12805407 15668230 18644861 20713355 27898060 stimulant N/A OmniPath
PRKDC DCLRE1C 11955432 15456891 15936993 16600297 16857680 16874298 27898060 stimulant N/A OmniPath
PRKDC IGFBP3 17108124 23178489 23557743 27898060 N/A N/A OmniPath
CASP3 PRKDC 12867423 27898060 8670824 8798786 8804412 inhibition,stimulant N/A OmniPath
PRKDC MDM2 11504915 12167711 27898060 stimulant N/A OmniPath
ATR PRKDC 12186630 12649176 16908529 17189255 19103741 20406977 22592045 24687855 27898060 stimulant N/A OmniPath
PIDD1 PRKDC 19203584 27898060 stimulant N/A OmniPath
ATM PRKDC 10464290 10608806 17189255 27898060 stimulant N/A OmniPath
PRKDC AKT1 15262962 15678105 18439899 27898060 stimulant N/A OmniPath
PRKDC WRN 10608806 11889123 18157161 20516064 24429382 27898060 stimulant N/A OmniPath
KAT5 PRKDC 16603769 16904321 27898060 stimulant N/A OmniPath
PRKDC RPA1 10064605 18157161 21504906 24332808 27898060 N/A N/A OmniPath
PRKDC CASP2 19203584 27898060 stimulant N/A OmniPath
PRKDC TRIM28 19444312 27898060 stimulant N/A OmniPath
PRKDC TP53 10446957 10470151 10608806 10673501 10713094 10747897 10951572 11483158 11551930 11709713 11883897 12756247 12959929 15381073 19918261 25362358 27898060 9363941 9679063 9744860 9765199 stimulant N/A OmniPath
PRKDC HSP90AA1 2492519 2507541 27898060 N/A N/A OmniPath
PRKDC XRCC4 12218164 14599745 15177042 15194694 15520013 22939629 25166505 27898060 9430729 N/A N/A OmniPath
ABL1 PRKDC 15686624 18157161 27898060 9109492 9295282 9312071 inhibition N/A OmniPath
PRKDC ABL1 15686624 18157161 27898060 9109492 9295282 9312071 stimulant N/A OmniPath
PRKDC IRF3 11867762 27898060 stimulant N/A OmniPath
PRKDC UPF1 18158334 27898060 inhibition,stimulant N/A OmniPath
HSF1 PRKDC 12919958 27898060 9325337 stimulant N/A OmniPath
PRKDC FUS 18620545 22579282 23833192 27898060 N/A N/A OmniPath
XRCC6 PRKDC 10064605 10446239 10750018 11279128 15520013 19133841 20711232 21969602 22939629 26496610 27898060 8422676 9312071 stimulant N/A OmniPath
PRKDC XRCC6 10026262 10064605 10446239 10750018 11279128 15520013 15941674 20711232 21969602 22939629 26496610 27898060 8422676 9312071 9362500 N/A N/A OmniPath
PRKDC RPA2 10064605 10713094 11731442 14872059 16540648 16872911 18669648 20016603 21558276 24332808 24830725 27898060 9139719 9295339 stimulant N/A OmniPath
PRKDC H1-1 18250087 27898060 inhibition N/A OmniPath
PRKDC SMC1A 18157161 27898060 N/A N/A OmniPath
PRKDC TDP1 19851285 20009512 27898060 stimulant N/A OmniPath
PRKDC H2AX 10477747 10734083 12766154 12907603 14627815 15226436 15289343 15604242 15610743 15613478 15846060 15897892 16024600 16039583 16061642 16148027 16377563 16452482 16673875 16788066 16818713 16820894 16935931 17412408 17525342 17594478 17634426 17638905 17723002 18157161 18406329 18438399 18454178 18632646 18632984 18657500 18829552 18987440 19049966 19092802 19234442 19305155 19321613 20053681 20224553 20356835 20395202 20488183 20703100 20921231 20978201 21151168 21653549 21731742 21874023 22184063 23185622 23620287 23891091 24059746 24145406 24415760 25355892 25487737 25537504 25699710 25702873 25843623 26438602 27898060 9488723 stimulant N/A OmniPath
XRCC5 PRKDC 10207052 10446239 10750018 12393188 15520013 15758953 16857680 18285803 20023628 20711232 21679440 22404984 24098118 26344197 26496610 27898060 9312071 stimulant N/A OmniPath
PRKDC XRCC5 10026262 10207052 10446239 10750018 12393188 15520013 15758953 16857680 18285803 20023628 20711232 21679440 22404984 24098118 26344197 26496610 27898060 9312071 N/A N/A OmniPath
PRKDC EIF2AK4 19451221 27898060 inhibition N/A OmniPath
PRKDC USF1 19303849 27898060 stimulant N/A OmniPath
PRKDC GOLPH3 24485452 27898060 N/A N/A OmniPath
PRKDC HERC2 20023648 27898060 stimulant N/A OmniPath
PRKDC POU2F1 14612514 17213819 27898060 9368058 inhibition N/A OmniPath
HINFP PRKDC 17974976 27898060 stimulant N/A OmniPath
PRKDC XRCC1 16397295 27898060 N/A N/A OmniPath
PRKDC HNRNPC 12564933 27898060 N/A N/A OmniPath
PRKDC SRF 11859076 1547771 27898060 8407951 N/A N/A OmniPath
MAPK8 PRKDC 11749722 16319174 27898060 N/A N/A OmniPath
PRKDC MAPK8 11749722 16319174 27898060 stimulant N/A OmniPath
PRKDC NR3C1 12000743 12351702 15817653 2019585 27898060 7873448 9038175 9199329 N/A N/A OmniPath
PRKDC JUN 1516134 1846781 19413330 1956339 27898060 8464713 N/A N/A OmniPath
PRKDC PNKP 21824916 27898060 stimulant N/A OmniPath
PRKDC RAG2 17562296 27898060 N/A N/A OmniPath
PRKDC LIG4 10608806 15194694 27898060 inhibition N/A OmniPath
PPP6C PRKDC 19198648 20065038 24255178 27898060 N/A N/A OmniPath
PRKDC MED1 12356758 16314496 23850489 25481872 27898060 N/A N/A OmniPath
PRKDC AIRE 17997173 20085707 27898060 N/A N/A OmniPath
HOXB7 PRKDC 17308091 27898060 stimulant N/A OmniPath
PRKDC PNPT1 22815474 27898060 N/A N/A OmniPath
PRKDC PDX1 16166097 27898060 N/A N/A OmniPath
PRKDC H1-2 18258596 22249259 24601643 27898060 N/A N/A OmniPath

Visualization










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