Gene Information gene info

  1. Home

GENE：SIRT3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIRT3
FullNmae sirtuin 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14931
EnsembleID ENSG00000142082
Uniprot Q9NTG7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIRT3 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SIRT3 GO:0005515,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005759,GO:0006338,GO:0006476,GO:0008270,GO:0009060,GO:0017136,GO:0019899,GO:0032024,GO:0032991,GO:0034979,GO:0034979,GO:0034983,GO:0034983,GO:0043565,GO:0070373,GO:0070403,GO:1901671,GO:1902553,GO:2000304,GO:2000378

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SIRT3 hsa:23410 path:hsa00760 Nicotinate and nicotinamide metabolism - Homo sapiens (human)
SIRT3 hsa:23410 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SIRT3 hsa:23410 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SIRT3 HIF1A 21109197 22850421 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
SMARCA4 SIRT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SIRT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SIRT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SIRT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SIRT3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004505E4 SIRT3 25416803 27107702 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000032835F SIRT3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000070CD2 SIRT3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075AB0E SIRT3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 SIRT3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000005A8ED SIRT3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 SIRT3 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 SIRT3 22135298 phosphorylation N/A PhosphoSite
NDUFA9 SIRT3 25361965 interaction type N/A PTMCode2
SIRT3 NDUFA9 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ATP5F1B SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
UQCRH SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
TTF2 SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
GRN SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
PITPNA SIRT3 19343720 24234451 25348397 physical association pull down ComPPI,IntAct
NIT1 SIRT3 25348397 N/A physical interaction ComPPI
HSPA5 SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
HSP90B1 SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
XRCC6 SIRT3 25348397 N/A physical interaction ComPPI
PDP1 SIRT3 25348397 N/A physical interaction ComPPI
MAP2K5 SIRT3 19343720 24234451 25348397 physical association pull down ComPPI,IntAct
FECH SIRT3 25348397 N/A physical interaction ComPPI
PDHA1 SIRT3 25348397 N/A physical interaction ComPPI
DMC1 SIRT3 25348397 N/A physical interaction ComPPI
MDM2 SIRT3 25348397 N/A physical interaction ComPPI
HSPA4 SIRT3 25348397 N/A physical interaction ComPPI
SKP2 SIRT3 22770219 23045395 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,deacetylase assay ComPPI,IntAct,OmniPath
HSPA9 SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
DNM1L SIRT3 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DLAT SIRT3 24234451 25348397 25525879 deacetylation reaction deacetylase assay ComPPI,IntAct
SBF1 SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SNTB1 SIRT3 25348397 N/A physical interaction ComPPI
ASS1 SIRT3 25348397 N/A physical interaction ComPPI
PDK1 SIRT3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RIF1 SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
FOXO3 SIRT3 18781224 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
NDUFS7 SIRT3 25348397 N/A physical interaction ComPPI
CMYA5 SIRT3 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
NCAPD2 SIRT3 25348397 N/A physical interaction ComPPI
HSPD1 SIRT3 19343720 21840382 24234451 25348397 27898060 29568061 association,physical association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct,OmniPath
ALDH2 SIRT3 21720390 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
ATP5F1A SIRT3 19343720 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
MRPL42 SIRT3 25348397 N/A physical interaction ComPPI
SIRT3 PEX5 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SIRT3 SIRT4 17715127 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT3 SIRT5 25348397 N/A physical interaction ComPPI
SIRT3 HSPA1L 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT3 PGAP1 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT3 HERC2 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT3 HERC2P3 25348397 N/A physical interaction ComPPI
SIRT3 UGDH 19343720 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SIRT3 LSM14B 25348397 N/A physical interaction ComPPI
SIRT3 ARHGEF26 25348397 N/A physical interaction ComPPI
SIRT3 NDUFA10 25348397 N/A physical interaction ComPPI
SIRT3 CNP 25348397 N/A physical interaction ComPPI
SIRT3 SDHA 25348397 N/A physical interaction ComPPI
SIRT3 REG4 25348397 N/A physical interaction ComPPI
SIRT3 TMEM25 25348397 N/A physical interaction ComPPI
SIRT3 YBEY 25348397 N/A physical interaction ComPPI
SIRT3 METAP1D 25348397 N/A physical interaction ComPPI
SIRT3 SDHB 25348397 N/A physical interaction ComPPI
SIRT3 OXLD1 25348397 N/A physical interaction ComPPI
SIRT3 ATP5F1D 25348397 N/A physical interaction ComPPI
SIRT3 MTG2 25348397 N/A physical interaction ComPPI
SIRT3 CA5A 25348397 N/A physical interaction ComPPI
SIRT3 NDUFA9 18794531 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIRT3 ACSS1 25348397 N/A anti tag coimmunoprecipitation,deacetylation reaction,physical interaction,deacetylase assay ComPPI
SIRT3 OPA1 24234451 24344202 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
TRIM43 SIRT3 25348397 N/A physical interaction ComPPI
HSCB SIRT3 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
CDK1 SIRT3 26141949 27898060 N/A N/A OmniPath
SIRT3 XRCC6 18710944 27898060 stimulant N/A OmniPath
SIRT3 IDH2 22416140 27898060 stimulant N/A OmniPath

Visualization










  Return