Gene Information gene info

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GENE：CGAS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CGAS
FullNmae cyclic GMP-AMP synthase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21367
EnsembleID ENSG00000164430
Uniprot Q8N884

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CGAS ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CGAS GO:0002218,GO:0002218,GO:0002218,GO:0002221,GO:0002230,GO:0002230,GO:0002230,GO:0002637,GO:0002753,GO:0003677,GO:0003682,GO:0003682,GO:0003690,GO:0003690,GO:0005515,GO:0005524,GO:0005525,GO:0005546,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0006281,GO:0006974,GO:0006974,GO:0008340,GO:0016604,GO:0019933,GO:0019934,GO:0031491,GO:0032481,GO:0032481,GO:0032481,GO:0035861,GO:0035861,GO:0038001,GO:0038001,GO:0042803,GO:0045087,GO:0045088,GO:0045824,GO:0046872,GO:0050863,GO:0051607,GO:0061501,GO:0061501,GO:0061501,GO:0071360,GO:0140693,GO:0160004,GO:2000042,GO:2000042,GO:2000774

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CGAS hsa:115004 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
CGAS hsa:115004 path:hsa05131 Shigellosis - Homo sapiens (human)
CGAS hsa:115004 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
CGAS hsa:115004 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
CGAS hsa:115004 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
CGAS hsa:115004 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IFI16 CGAS 23180781 25831530 physical association anti tag coimmunoprecipitation InnateDB
PQBP1 CGAS 23180781 26046437 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 CGAS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CGAS 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000195F5B CGAS 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 CGAS 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 CGAS 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 CGAS 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 CGAS 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 CGAS 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 CGAS 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C5BAA CGAS 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D CGAS 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005651EE CGAS 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002D349B CGAS 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000913AC CGAS 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075B538 CGAS 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000284586 CGAS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000035D2F9 CGAS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 CGAS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001925C1 CGAS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB35 CGAS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000031BC7D CGAS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 CGAS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000031D186 CGAS 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB CGAS 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MPHOSPH8 CGAS 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELAVL1 CGAS 25348397 N/A physical interaction ComPPI
LDHD CGAS 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZNF593 CGAS 25348397 N/A physical interaction ComPPI
PHF8 CGAS 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF185 CGAS 25348397 N/A physical interaction ComPPI
TUBGCP5 CGAS 23891004 30476227 physical association affinity chromatography technology TheBiogrid
CGAS FAM83F 26496610 30476227 physical association affinity chromatography technology TheBiogrid
CGAS OMA1 26496610 30476227 physical association affinity chromatography technology TheBiogrid
IFI16 CGAS 25831530 27898060 N/A N/A OmniPath

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