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GENE：STING1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol STING1
FullNmae stimulator of interferon response cGAMP interactor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:27962
EnsembleID ENSG00000184584
Uniprot Q86WV6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
STING1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
STING1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
STING1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
STING1 GO:0000045,GO:0000045,GO:0000139,GO:0000421,GO:0002218,GO:0002218,GO:0002218,GO:0002221,GO:0002230,GO:0002753,GO:0005515,GO:0005654,GO:0005741,GO:0005768,GO:0005776,GO:0005776,GO:0005777,GO:0005789,GO:0005789,GO:0005789,GO:0005829,GO:0005886,GO:0016239,GO:0016239,GO:0019901,GO:0019901,GO:0030659,GO:0030667,GO:0031625,GO:0032092,GO:0032481,GO:0032481,GO:0032728,GO:0032728,GO:0033116,GO:0035438,GO:0035438,GO:0035458,GO:0035591,GO:0042802,GO:0042803,GO:0045087,GO:0045087,GO:0045087,GO:0045944,GO:0048471,GO:0050727,GO:0051091,GO:0051259,GO:0051607,GO:0051607,GO:0051607,GO:0060340,GO:0061507,GO:0061507,GO:0061507,GO:0061629,GO:0061709,GO:0061709,GO:0071360,GO:0071407,GO:0140374,GO:1902554,GO:1990231

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
STING1 hsa:340061 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
STING1 hsa:340061 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
STING1 hsa:340061 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
STING1 hsa:340061 path:hsa05131 Shigellosis - Homo sapiens (human)
STING1 hsa:340061 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
STING1 hsa:340061 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
STING1 hsa:340061 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
STING1 hsa:340061 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STING1 MAVS 18724357 18818105 19416887 20019757 22844514 22911572 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 DDX58 18724357 18818105 23180781 physical association anti tag coimmunoprecipitation InnateDB
TBK1 STING1 18724357 18818105 19416887 21074459 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 IRF3 18818105 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 STING1 18818105 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3 STING1 18818105 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 STING1 18818105 21074459 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 SSR2 18724357 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
STING1 RNF5 19285439 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 IFIT1 19416887 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 IFIT2 19416887 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAVS STING1 20019757 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 IFI16 20890285 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
STAT6 STING1 22000020 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
STING1 LTN1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 NPC1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 SLC39A14 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 CLPTM1L 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 TMEM259 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 ABCC1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 STT3B 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 TBK1 21903422 22394562 23180781 26199418 physical association anti tag coimmunoprecipitation,pull down InnateDB
STING1 YIPF5 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 SEC61A1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 CNNM3 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 HM13 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 CCDC47 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 MBOAT7 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 STT3A 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 SGPL1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 ACSL3 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 IRAK1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 SURF4 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 GLMN 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 DDOST 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKE STING1 18818105 23180781 physical association anti tag coimmunoprecipitation InnateDB
STING1 ELF4 23180781 24185615 physical association anti tag coimmunoprecipitation,comigration in sds page InnateDB
IRF3 STING1 22394562 23180781 physical association pull down InnateDB
STING1 ULK1 23180781 24119841 phosphorylation reaction protein kinase assay InnateDB
STING1 TSPAN6 22908223 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRIM32 STING1 23180781 25505063 physical association anti tag coimmunoprecipitation InnateDB
TRIM56 STING1 23180781 25505063 physical association anti tag coimmunoprecipitation InnateDB
PQBP1 STING1 23180781 26046437 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 STING1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 STING1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 STING1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 STING1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA STING1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF STING1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 STING1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS STING1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR STING1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000C85B2 STING1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C4DB5 STING1 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TBK1 STING1 22135298 phosphorylation N/A PhosphoSite
ULK1 STING1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
EXOSC5 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
USP20 STING1 25348397 N/A physical interaction ComPPI
MITD1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF2B2 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
SKP1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
TRIM32 STING1 25348397 N/A physical interaction ComPPI
RNF5 STING1 25348397 N/A physical interaction ComPPI
UBB STING1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC STING1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A STING1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 STING1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
IRF3 STING1 25348397 N/A physical interaction ComPPI
PTPN1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
SEC61B STING1 18724357 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF3 STING1 25348397 N/A physical interaction ComPPI
TPR STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
IRAK1 STING1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF2 STING1 25348397 N/A physical interaction ComPPI
USP13 STING1 25348397 N/A physical interaction ComPPI
SAE1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
SSR2 STING1 18724357 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
GLMN STING1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAT6 STING1 22000020 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,confocal microscopy ComPPI,IntAct
AUP1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
MYO6 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
GRIPAP1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
CD40 STING1 25348397 N/A physical interaction ComPPI
TBK1 STING1 18724357 19416887 19433799 21903422 23542348 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SSR1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
STX5 STING1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDX54 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
STAT3 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
PRKD2 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
USP49 STING1 25348397 N/A physical interaction ComPPI
IKBKE STING1 19433799 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAN2 STING1 25348397 N/A physical interaction ComPPI
IFI16 STING1 20890285 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HM13 STING1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ZSWIM8 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
NECTIN4 STING1 25348397 N/A physical interaction ComPPI
SEC61A1 STING1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRCC STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
IFIT2 STING1 19416887 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP18 STING1 25348397 N/A physical interaction ComPPI
IFIT1 STING1 19416887 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP2 STING1 25348397 N/A physical interaction ComPPI
CNNM3 STING1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IL1B STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
MUL1 STING1 25348397 N/A physical interaction ComPPI
HRG STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
MAVS STING1 22000020 22911572 23542348 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
YIPF5 STING1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DNMT1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
CCDC47 STING1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TMEM259 STING1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TSPAN6 STING1 25348397 N/A physical interaction ComPPI
STT3A STING1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
INTS1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
INTS4 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
VAC14 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
DDX58 STING1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
TOMM70 STING1 25348397 N/A physical interaction ComPPI
LEPROTL1 STING1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAPH1 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
DDOST STING1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SURF4 STING1 21903422 24234451 25348397 29251827 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP22 STING1 25348397 N/A physical interaction ComPPI
USP3 STING1 25348397 N/A physical interaction ComPPI
USP50 STING1 25348397 N/A physical interaction ComPPI
RBM45 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
INTS7 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
NPC1 STING1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF26 STING1 25254379 25348397 27898060 N/A physical interaction ComPPI,OmniPath
LTN1 STING1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM56 STING1 25348397 N/A physical interaction ComPPI
CLPTM1L STING1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
INTS2 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
STING1 ABCC1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STING1 SLC39A14 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STING1 ACSL3 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STING1 MBOAT7 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STING1 SGPL1 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STING1 STT3B 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STING1 USP35 25348397 N/A physical interaction ComPPI
STING1 ACSL4 22911572 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
STING1 AGPAT2 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
STING1 ZNF780B 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
STING1 SLC16A7 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
PLLP STING1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZNF16 STING1 21874239 24234451 25348397 physical association two hybrid ComPPI,IntAct
STING1 STING1 19433799 22728658 22728659 22728660 23542348 24234451 30405246 physical association anti tag coimmunoprecipitation,dynamic light scattering,molecular sieving,x-ray crystallography,comigration in non denaturing gel electrophoresis,comigration in sds page IntAct
STING1 STAT6 22000020 27898060 N/A N/A OmniPath
ELF4 STING1 24185615 27898060 N/A N/A OmniPath
STING1 IKBKE 18818105 27898060 stimulant N/A OmniPath
ULK1 STING1 24119841 26118643 27898060 N/A N/A OmniPath
MAVS STING1 18724357 18818105 19416887 20019757 22844514 22908223 22911572 23542348 24622840 27898060 N/A N/A OmniPath
IRF3 STING1 18818105 22394562 24622840 25636800 27898060 N/A N/A OmniPath
STING1 IRF7 18818105 27898060 N/A N/A OmniPath
DDX58 STING1 18724357 18818105 27898060 N/A N/A OmniPath
STING1 IFIT1 19416887 27898060 N/A N/A OmniPath
TBK1 STING1 18724357 18818105 19416887 21074459 21903422 22394562 22579474 22745133 23542348 24391220 24622840 27898060 N/A N/A OmniPath
STING1 IRAK1 21903422 27898060 N/A N/A OmniPath
TRAF3 STING1 18818105 27898060 N/A N/A OmniPath
STING1 YIPF5 21903422 27898060 N/A N/A OmniPath
STING1 CCDC47 21903422 27898060 N/A N/A OmniPath
STING1 CNNM3 21903422 27898060 N/A N/A OmniPath
STING1 ACSL3 21903422 27898060 N/A N/A OmniPath
STING1 TSPAN6 22908223 27898060 N/A N/A OmniPath
TRIM56 STING1 25505063 27898060 N/A N/A OmniPath
STING1 NPC1 21903422 27898060 N/A N/A OmniPath
STING1 SGPL1 21903422 27898060 N/A N/A OmniPath
STING1 STT3B 21903422 27898060 N/A N/A OmniPath
STING1 HM13 21903422 27898060 N/A N/A OmniPath
STING1 IFIT2 19416887 27898060 N/A N/A OmniPath
STING1 IFI16 20890285 27898060 N/A N/A OmniPath
STING1 CDC34 21903422 27898060 N/A N/A OmniPath
STING1 CLPTM1L 21903422 27898060 N/A N/A OmniPath
STING1 TMEM259 21903422 27898060 N/A N/A OmniPath
STING1 DDOST 21903422 27898060 N/A N/A OmniPath
STING1 MBOAT7 21903422 27898060 N/A N/A OmniPath
TRIM32 STING1 22745133 25505063 27898060 N/A N/A OmniPath
STING1 GLMN 21903422 27898060 N/A N/A OmniPath
STING1 SLC39A14 21903422 27898060 N/A N/A OmniPath
STING1 ABCC1 21903422 27898060 N/A N/A OmniPath
STING1 SEC61A1 21903422 27898060 N/A N/A OmniPath
STING1 SURF4 21903422 27898060 N/A N/A OmniPath
STING1 STT3A 21903422 27898060 N/A N/A OmniPath
STING1 SSR2 18724357 27898060 N/A N/A OmniPath
RNF5 STING1 19285439 27898060 N/A N/A OmniPath

Visualization










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