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GENE：WWTR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol WWTR1
FullNmae WW domain containing transcription regulator 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24042
EnsembleID ENSG00000018408
Uniprot Q9GZV5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
WWTR1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WWTR1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
WWTR1 GO:0000122,GO:0001649,GO:0001894,GO:0001933,GO:0003015,GO:0003713,GO:0003713,GO:0003713,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0006355,GO:0006469,GO:0008284,GO:0010718,GO:0016567,GO:0016604,GO:0017145,GO:0031146,GO:0032835,GO:0035264,GO:0035329,GO:0035329,GO:0042803,GO:0045599,GO:0045669,GO:0045944,GO:0048762,GO:0060271,GO:0060390,GO:0060993,GO:0072307,GO:0090090,GO:1900182

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
WWTR1 hsa:25937 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
WWTR1 hsa:25937 path:hsa04392 Hippo signaling pathway - multiple species - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YAP1 WWTR1 12807903 18280240 18617895 21666501 23708000 25502501 26192618 26711338 7782338 association N/A ACSN
WWTR1 SERPINE1 12807903 18280240 18617895 21666501 23708000 25502501 26192618 26711338 7782338 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR WWTR1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 WWTR1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 WWTR1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 WWTR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 WWTR1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000237AF9 WWTR1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000035CC3E WWTR1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000285DCB WWTR1 21572407 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 WWTR1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D WWTR1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 WWTR1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 WWTR1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 WWTR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD WWTR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008DA94 WWTR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002A71AD WWTR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A3D WWTR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 WWTR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 WWTR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000156390 WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 WWTR1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 WWTR1 22135298 phosphorylation N/A PhosphoSite
NKX2-1 WWTR1 25361965 interaction type N/A PTMCode2
WWTR1 NKX2-1 25361965 interaction type N/A PTMCode2
YWHAE WWTR1 25361965 interaction type N/A PTMCode2
WWTR1 YWHAE 25361965 interaction type N/A PTMCode2
TAZ WWTR1 25361965 interaction type N/A PTMCode2
WWTR1 TAZ 25361965 interaction type N/A PTMCode2
YWHAB WWTR1 25361965 interaction type N/A PTMCode2
WWTR1 YWHAB 25361965 interaction type N/A PTMCode2
WWTR1 SLC9A3R2 25361965 interaction type N/A PTMCode2
SLC9A3R2 WWTR1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NUDT21 WWTR1 20972459 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
AMOT WWTR1 20972459 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WBP2 WWTR1 20972459 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,confocal microscopy ComPPI,IntAct
YWHAG WWTR1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TP53BP2 WWTR1 25348397 N/A physical interaction ComPPI
DDX17 WWTR1 24234451 24581491 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
NOTCH1 WWTR1 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HIF1A WWTR1 25348397 N/A physical interaction ComPPI
SLC9A3R2 WWTR1 11118213 14525934 24234451 25348397 colocalization,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique,in vitro ComPPI,HPRD,IntAct
JUP WWTR1 23245942 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAZ WWTR1 11118213 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
BTRC WWTR1 22078877 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AXIN1 WWTR1 24234451 24976009 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
YBX1 WWTR1 20972459 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP1CA WWTR1 25348397 N/A physical interaction ComPPI
NKX2-1 WWTR1 14525934 14970209 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
KLF5 WWTR1 25348397 N/A physical interaction ComPPI
YWHAQ WWTR1 25348397 N/A physical interaction ComPPI
DVL1 WWTR1 20412773 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
DVL2 WWTR1 20412773 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
YWHAE WWTR1 11118213 14525934 16099986 18227151 20936779 21189257 24234451 25348397 25961935 27898060 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid pooling approach,in vivo ComPPI,HPRD,IntAct,OmniPath
YAP1 WWTR1 24234451 24976009 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CTNNB1 WWTR1 22234184 23245942 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
RTN4 WWTR1 24234451 25348397 25416956 physical association bimolecular fluorescence complementation ComPPI,IntAct
MED28 WWTR1 16964398 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
TJP2 WWTR1 20850437 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
WNK1 WWTR1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PAX3 WWTR1 14525934 16300735 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
TRIM25 WWTR1 25348397 N/A physical interaction ComPPI
WWTR1 TEAD4 14525934 16189514 20972459 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
WWTR1 TEAD3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
WWTR1 RUNX1 11118213 14525934 24234451 25348397 physical association beta lactamase complementation,experimental interaction detection,filter binding,in vitro ComPPI,HPRD,IntAct
WWTR1 LATS1 20412773 22078877 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
WWTR1 DVL1P1 25348397 N/A physical interaction ComPPI
WWTR1 DVL3 20412773 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWTR1 AMOTL1 20972459 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWTR1 TEAD1 25348397 N/A physical interaction ComPPI
WWTR1 FBXW11 25348397 N/A physical interaction ComPPI
WWTR1 TEAD2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
WWTR1 LATS2 25348397 N/A physical interaction ComPPI
WWTR1 TJP1 20850437 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
WWTR1 CCAR1 20594350 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
WWTR1 STK3 22078877 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
WWTR1 SCRIB 22078877 24234451 25348397 30126976 association anti bait coimmunoprecipitation,p8 filamentous phage display ComPPI,IntAct
WWTR1 CCT2 23245942 24234451 25348397 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct
WWTR1 C1ORF74 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WWTR1 RTN4IP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WWTR1 TCP11L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WWTR1 DAPK1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
WWTR1 MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
WWTR1 SHANK1 24234451 30126976 N/A p8 filamentous phage display IntAct
WWTR1 SNTA1 24234451 30126976 N/A p8 filamentous phage display IntAct
NEK1 WWTR1 21474562 27898060 N/A N/A OmniPath
WWTR1 MYOD1 20466877 27898060 stimulant N/A OmniPath
CSNK1E WWTR1 24715453 27898060 inhibition,stimulant N/A OmniPath
WWTR1 PAX8 19010321 27898060 stimulant N/A OmniPath
CDK1 WWTR1 26183396 26375055 27898060 N/A N/A OmniPath
LATS1 WWTR1 20412773 21555462 21808241 22078877 22658639 27898060 inhibition N/A OmniPath
CSNK1D WWTR1 24715453 27898060 inhibition N/A OmniPath
WWTR1 SMAD2 21084559 27898060 stimulant N/A OmniPath
LATS2 WWTR1 18227151 21808241 22658639 27898060 inhibition N/A OmniPath
WWTR1 PPARG 22153608 27898060 inhibition N/A OmniPath
WWTR1 NKX2-1 14970209 16397409 27898060 stimulant N/A OmniPath
WWTR1 DVL1 20412773 22153608 27898060 inhibition N/A OmniPath
WWTR1 SMAD3 21084559 27898060 stimulant N/A OmniPath
WWTR1 RUNX2 22153608 27898060 stimulant N/A OmniPath
TJP2 WWTR1 20850437 21808241 27898060 inhibition N/A OmniPath
WWTR1 TEAD4 16189514 20972459 23431053 25670202 26186194 27898060 stimulant N/A OmniPath
AMOT WWTR1 21205866 23431053 27898060 inhibition N/A OmniPath
WWTR1 TTF1 19010321 27898060 stimulant N/A OmniPath
WWTR1 TEAD1 23431053 27898060 stimulant N/A OmniPath
WWTR1 TEAD2 23431053 27898060 stimulant N/A OmniPath
WWTR1 TEAD3 16189514 23431053 26186194 27898060 stimulant N/A OmniPath

Visualization










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