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GENE：HIPK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HIPK2
FullNmae homeodomain interacting protein kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14402
EnsembleID ENSG00000064393
Uniprot Q9H2X6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HIPK2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HIPK2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HIPK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HIPK2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HIPK2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HIPK2 GO:0000122,GO:0001654,GO:0001934,GO:0003016,GO:0003713,GO:0003713,GO:0003714,GO:0003714,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005737,GO:0006468,GO:0006978,GO:0007179,GO:0007224,GO:0007628,GO:0008283,GO:0008284,GO:0009952,GO:0010467,GO:0010494,GO:0010842,GO:0016604,GO:0016604,GO:0016605,GO:0016605,GO:0018105,GO:0018105,GO:0018105,GO:0018107,GO:0018107,GO:0030182,GO:0030218,GO:0030511,GO:0030514,GO:0030578,GO:0030878,GO:0032092,GO:0040029,GO:0042771,GO:0042771,GO:0043524,GO:0045766,GO:0045893,GO:0045944,GO:0045944,GO:0046330,GO:0046332,GO:0046332,GO:0046790,GO:0048596,GO:0050882,GO:0051091,GO:0051402,GO:0051726,GO:0060059,GO:0060235,GO:0060395,GO:0060425,GO:0061072,GO:0061629,GO:0071456,GO:0090575,GO:0097193,GO:0106310,GO:1901796,GO:2000059

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HIPK2 hsa:28996 path:hsa04218 Cellular senescence - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HIPK2 TCF4 10391247 11925430 12851404 15082531 17349959 18974774 19828042 26192618 interaction type N/A ACSN
TAB1 HIPK2 10391247 15082531 26192618 interaction type N/A ACSN
HIPK2 NLK 10391247 11925430 12851404 15082531 17349959 18974774 19828042 21118996 26192618 interaction type N/A ACSN
HIPK2 SKI 12874272 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
TGFBR1 HIPK2 17729308 23331499 stimulation N/A SignaLink,SignaLink
HIPK2 SMAD1 12874272 23331499 stimulation N/A SignaLink
HIPK2 CTBP1 14567915 23331499 stimulation N/A SignaLink
HIPK2 DAXX 14678985 19465479 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 HIPK2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 HIPK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HIPK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 HIPK2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 HIPK2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HIPK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PML HIPK2 18809579 trascriptional regulation,stimulation inferred by curator TFlink
TP53 HIPK2 11740489 trascriptional regulation,stimulation inferred by curator TFlink
TP73 HIPK2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001B341F HIPK2 20624637 rna interference,inhibition western blot,quantitative reverse transcription pcr miRSponge
URS00001B341F HIPK2 20624637 25416803 26793992 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000512C88 HIPK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 HIPK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C3AC1 HIPK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 HIPK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E HIPK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D HIPK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 HIPK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB HIPK2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003E1A9 HIPK2 25416803 25421593 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS00006AA21F HIPK2 25416803 26472042 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
SRC HIPK2 22135298 phosphorylation N/A PhosphoSite
ABL1 HIPK2 22135298 phosphorylation N/A PhosphoSite
HIPK2 ZBTB4 22135298 phosphorylation N/A PhosphoSite
HIPK2 RUNX1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
HIPK2 KLF3 22135298 phosphorylation N/A PhosphoSite
HIPK2 HMGA1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
HIPK2 NOTCH1 22135298 phosphorylation N/A PhosphoSite
HIPK2 CTBP1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
HIPK2 CTBP2 22135298 phosphorylation N/A PhosphoSite
HIPK2 PML 22135298 phosphorylation N/A PhosphoSite
HIPK2 TP53 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
HIPK2 PPM1D 22135298 phosphorylation N/A PhosphoSite
HIPK2 SIRT1 22135298 phosphorylation N/A PhosphoSite
HIPK2 HIPK2 22135298 phosphorylation N/A PhosphoSite
HIPK2 CDKN1B 22135298 phosphorylation N/A PhosphoSite
HIPK2 CBX4 22135298 phosphorylation N/A PhosphoSite
HIPK2 CREB1 22135298 phosphorylation N/A PhosphoSite
HIPK2 SIAH2 22135298 phosphorylation N/A PhosphoSite
HIPK2 TP63 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
HIPK2 CEBPB 22135298 phosphorylation N/A PhosphoSite
TP63 HIPK2 25361965 interaction type N/A PTMCode2
TP53 HIPK2 25361965 interaction type N/A PTMCode2
CTBP1 HIPK2 25361965 interaction type N/A PTMCode2
RUNX1 HIPK2 25361965 interaction type N/A PTMCode2
HMGA1 HIPK2 25361965 interaction type N/A PTMCode2
HIPK2 CUL1 25361965 interaction type N/A PTMCode2
CUL1 HIPK2 25361965 interaction type N/A PTMCode2
HIPK2 MYB 25361965 interaction type N/A PTMCode2
MYB HIPK2 25361965 interaction type N/A PTMCode2
HIPK2 TRADD 25361965 interaction type N/A PTMCode2
TRADD HIPK2 25361965 interaction type N/A PTMCode2
HIPK2 TP73 25361965 interaction type N/A PTMCode2
TP73 HIPK2 25361965 interaction type N/A PTMCode2
HIPK2 SKI 25361965 interaction type N/A PTMCode2
SKI HIPK2 25361965 interaction type N/A PTMCode2
HIPK2 SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 HIPK2 25361965 interaction type N/A PTMCode2
HIPK2 NLK 25361965 interaction type N/A PTMCode2
NLK HIPK2 25361965 interaction type N/A PTMCode2
HIPK2 DAXX 25361965 interaction type N/A PTMCode2
DAXX HIPK2 25361965 interaction type N/A PTMCode2
RANBP9 HIPK2 25361965 interaction type N/A PTMCode2
HIPK2 RANBP9 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I HIPK2 10535925 14525934 14609633 15896780 19549727 20936779 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid pooling approach,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
DAXX HIPK2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
LZTS2 HIPK2 25348397 N/A physical interaction ComPPI
NLK HIPK2 14525934 15082531 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TLE1 HIPK2 15896780 24234451 25348397 physical association pull down ComPPI,IntAct
SMAD1 HIPK2 12874272 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SIAH2 HIPK2 25348397 N/A physical interaction ComPPI
FBXW7 HIPK2 14525934 18765672 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CREBBP HIPK2 11740489 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HMGA1 HIPK2 11593421 14525934 25348397 N/A two hybrid,experimental interaction detection,protein kinase assay,in vitro,in vivo,two hybrid ComPPI,HPRD
SMAD2 HIPK2 12874272 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SUMO1 HIPK2 10535925 14525934 14609633 15896780 24234451 25348397 covalent binding,physical association anti bait coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
EP300 HIPK2 16917507 24234451 25348397 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,physical interaction,protein kinase assay ComPPI,IntAct
SMAD3 HIPK2 25348397 N/A physical interaction ComPPI
KAT2B HIPK2 14525934 16917507 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SIAH1 HIPK2 25348397 N/A physical interaction ComPPI
MYBL2 HIPK2 25348397 N/A physical interaction ComPPI
BTRC HIPK2 14525934 18765672 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
AXIN1 HIPK2 25348397 N/A physical interaction ComPPI
PARP1 HIPK2 25348397 N/A physical interaction ComPPI
HSPA1A HIPK2 25348397 N/A physical interaction ComPPI
HSPA1B HIPK2 25348397 N/A physical interaction ComPPI
HNRNPL HIPK2 25348397 N/A physical interaction ComPPI
NKX2-1 HIPK2 11438542 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
DYRK1B HIPK2 20940704 24234451 25348397 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct
TP73 HIPK2 11925430 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RANBP9 HIPK2 12220523 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
H2BC21 HIPK2 22658722 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CBX4 HIPK2 25348397 N/A physical interaction ComPPI
AATF HIPK2 25348397 N/A physical interaction ComPPI
SP100 HIPK2 14525934 14647468 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SUMO2 HIPK2 25348397 N/A physical interaction ComPPI
SUMO3 HIPK2 25348397 N/A physical interaction ComPPI
MDM2 HIPK2 14525934 16212962 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CUL1 HIPK2 14525934 18765672 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MBP HIPK2 25348397 N/A physical interaction ComPPI
MEF2C HIPK2 23565059 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HIPK2 NKX2-5 14525934 25348397 9748262 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
HIPK2 NKX3-1 10559189 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HIPK2 TP63 11925430 14525934 21602882 24234451 25348397 phosphorylation reaction two hybrid,experimental interaction detection,physical interaction,protein kinase assay,in vitro,two hybrid ComPPI,HPRD,IntAct
HIPK2 TRADD 11032752 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
HIPK2 TP53INP1 12851404 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HIPK2 DDX39A 14525934 14667819 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
HIPK2 MAP3K7 14525934 15082531 23565059 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
HIPK2 PAX6 14525934 16407227 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HIPK2 RUNX1 14525934 16917507 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
HIPK2 DDX39B 14525934 14667819 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
HIPK2 CHMP4B 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HIPK2 SKI 12874272 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HIPK2 TP53 11780126 11875057 11925430 14525934 15896780 16212962 21057547 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
HIPK2 MYB 14525934 15082531 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
HIPK2 MYBL1 25348397 N/A physical interaction ComPPI
HIPK2 WSB1 18093972 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HIPK2 CXCL1 25348397 N/A physical interaction ComPPI
HIPK2 SENP2 25348397 N/A physical interaction ComPPI
HIPK2 SENP1 25348397 N/A physical interaction ComPPI
HIPK2 FBXO3 25348397 N/A physical interaction ComPPI
HIPK2 PML 25348397 N/A physical interaction ComPPI
HIPK2 DCAF7 20940704 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
HIPK2 DYRK1A 20940704 24234451 25348397 colocalization physical interaction,fluorescence microscopy ComPPI,IntAct
HIPK2 MAP3K1 20940704 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HIPK2 ZBTB4 25348397 N/A physical interaction ComPPI
HIPK2 MECP2 19820693 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
HIPK2 MKNK1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HIPK2 XAF1 25348397 N/A physical interaction ComPPI
HIPK2 RGMA 25348397 N/A physical interaction ComPPI
HIPK2 ABL1 25348397 N/A physical interaction ComPPI
HIPK2 STUB1 25348397 N/A physical interaction ComPPI
HIPK2 ACTBL2 25348397 N/A physical interaction ComPPI
HIPK2 TRIM25 25348397 N/A physical interaction ComPPI
HIPK2 SETX 24234451 24244371 25348397 physical association two hybrid ComPPI,IntAct
HIPK2 PTCH1 12874272 14525934 N/A experimental interaction detection HPRD
HIPK2 HIPK2 14525934 14667819 N/A two hybrid HPRD
MAP3K7 HIPK2 15082531 27898060 stimulant N/A OmniPath
HIPK2 CREB1 19690332 20573984 27898060 stimulant N/A OmniPath
HIPK2 ATF1 18669648 19690332 20980392 27898060 N/A N/A OmniPath
SIAH1 HIPK2 18536714 19043406 19250734 19788416 23503458 27898060 inhibition N/A OmniPath
HIPK2 CDKN1B 21715331 27898060 stimulant N/A OmniPath
HIPK2 SMAD1 12874272 27898060 inhibition,stimulant N/A OmniPath
WSB1 HIPK2 18093972 19788416 27898060 inhibition N/A OmniPath
ATM HIPK2 17332358 19788416 27898060 inhibition,stimulant N/A OmniPath
HIPK2 PML 17081983 19015637 20188669 21145359 21192925 27898060 stimulant N/A OmniPath
HIPK2 CEBPB 12213825 16009338 16714289 17540774 18052938 18647749 19723873 21980398 23782693 27898060 N/A N/A OmniPath
HIPK2 ZBTB4 19448668 27898060 N/A N/A OmniPath
HIPK2 TP53 11740489 11780126 11875057 11925430 15896780 16212962 16729035 17210684 17332358 17349959 21057547 25313037 27898060 stimulant N/A OmniPath
HIPK2 CTBP1 14567915 15708980 19788416 27898060 inhibition,stimulant N/A OmniPath
HIPK2 DAXX 14678985 19465479 1946548 23536002 27898060 stimulant N/A OmniPath
HIPK2 PAX6 16407227 27898060 inhibition,stimulant N/A OmniPath
CASP6 HIPK2 16601678 19788416 27898060 stimulant N/A OmniPath
HIPK2 RUNX1 16917507 169175071 18695000 19690332 27898060 N/A N/A OmniPath
HIPK2 HMGA1 11593421 17081983 17924679 17960875 18669648 19413330 27898060 inhibition N/A OmniPath
HIPK2 NLK 15082531 27898060 stimulant N/A OmniPath
SIAH2 HIPK2 19043406 19788416 25313037 27898060 inhibition N/A OmniPath
TGFBR1 HIPK2 17729308 27898060 stimulant N/A OmniPath
HIPK2 SKI 12874272 27898060 stimulant N/A OmniPath
HIPK2 CBX4 17018294 21145359 27898060 stimulant N/A OmniPath
HIPK2 KLF3 25659434 27898060 N/A N/A OmniPath
HIPK2 PDX1 20637728 27898060 N/A N/A OmniPath

Visualization










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