GENE：LGMN
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LGMN |
| FullNmae | legumain |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9472 |
| EnsembleID | ENSG00000100600 |
| Uniprot | Q99538 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LGMN | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| LGMN | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LGMN | GO:0003014,GO:0004197,GO:0004197,GO:0004197,GO:0004197,GO:0004197,GO:0005576,GO:0005737,GO:0005764,GO:0005764,GO:0005770,GO:0006508,GO:0006624,GO:0007613,GO:0008233,GO:0008284,GO:0008306,GO:0010447,GO:0010447,GO:0010629,GO:0019886,GO:0032801,GO:0035729,GO:0036021,GO:0040015,GO:0042359,GO:0043202,GO:0043524,GO:0045177,GO:0045931,GO:0048156,GO:0048471,GO:0051603,GO:0051603,GO:0051603,GO:0070062,GO:0071277,GO:0090026,GO:0097061,GO:0097202,GO:0097264,GO:1900273,GO:1901185,GO:1904646,GO:2001028 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LGMN | hsa:5641 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| LGMN | hsa:5641 | path:hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LGMN | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | LGMN | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | LGMN | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | LGMN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000F31F4 | LGMN | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | LGMN | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | LGMN | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000E7139 | LGMN | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ISG15 | LGMN | 25348397 | N/A | physical interaction | ComPPI |
| TRAF6 | LGMN | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPH2 | LGMN | 25348397 | N/A | physical interaction | ComPPI |
| YWHAH | LGMN | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| GABARAP | LGMN | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| HNRNPR | LGMN | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | LGMN | 25348397 | N/A | physical interaction | ComPPI |
| ACIN1 | LGMN | 25348397 | N/A | physical interaction | ComPPI |
| SOD1 | LGMN | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LGMN | USP17L11 | 25348397 | N/A | physical interaction | ComPPI |
| LGMN | USP17L22 | 25348397 | N/A | physical interaction | ComPPI |
| LGMN | USP17L20 | 25348397 | N/A | physical interaction | ComPPI |
| LGMN | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
| LGMN | IGF2BP3 | 25348397 | N/A | physical interaction | ComPPI |
| LGMN | LAMC3 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| LGMN | USP17L2 | 25348397 | N/A | physical interaction | ComPPI |
| LGMN | PDIA5 | 25348397 | N/A | physical interaction | ComPPI |
| LGMN | ATG7 | 25348397 | N/A | physical interaction | ComPPI |
| LGMN | RNASEH2A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LGMN | PPP2R3C | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| LGMN | DEFA1 | 25348397 | N/A | physical interaction | ComPPI |
| LGMN | USP17L24 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| LGMN | GABARAPL1 | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| HSCB | LGMN | 24234451 25348397 28380382 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| LGMN | LGMN | 11085925 12860980 14525934 | N/A | experimental interaction detection | HPRD |
| ISG15 | LGMN | 16009940 27898060 | N/A | N/A | OmniPath |
| CD74 | LGMN | 14966190 27898060 | N/A | N/A | OmniPath |
| HLA-DRB1 | LGMN | 14966190 27898060 | N/A | N/A | OmniPath |