GENE：SMPD1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SMPD1 |
| FullNmae | sphingomyelin phosphodiesterase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11120 |
| EnsembleID | ENSG00000166311 |
| Uniprot | P17405 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SMPD1 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SMPD1 | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| SMPD1 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| SMPD1 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| SMPD1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SMPD1 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SMPD1 | GO:0001778,GO:0004767,GO:0004767,GO:0005515,GO:0005615,GO:0005615,GO:0005764,GO:0005764,GO:0005768,GO:0005811,GO:0005886,GO:0006684,GO:0006685,GO:0006685,GO:0006687,GO:0007165,GO:0007399,GO:0008203,GO:0008270,GO:0009410,GO:0009615,GO:0010212,GO:0016798,GO:0023021,GO:0034340,GO:0034480,GO:0034612,GO:0034644,GO:0035307,GO:0036019,GO:0042060,GO:0042220,GO:0042599,GO:0043065,GO:0043202,GO:0043407,GO:0045807,GO:0046513,GO:0046513,GO:0046513,GO:0046598,GO:0046718,GO:0061750,GO:0061750,GO:0070062,GO:0070555,GO:0071277 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SMPD1 | hsa:6609 | path:hsa00600 | Sphingolipid metabolism - Homo sapiens (human) |
| SMPD1 | hsa:6609 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| SMPD1 | hsa:6609 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| SMPD1 | hsa:6609 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| SMPD1 | hsa:6609 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | SMPD1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | SMPD1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SP1 | SMPD1 | 10224156 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| TFAP2A | SMPD1 | 10224156 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | SMPD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SMPD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SMPD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SMPD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SMPD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SMPD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SMPD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | SMPD1 | 10224156 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AR | SMPD1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | SMPD1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | SMPD1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DUSP23 | SMPD1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ANXA4 | SMPD1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| CANX | SMPD1 | 25348397 | N/A | physical interaction | ComPPI |
| CASP7 | SMPD1 | 21157428 24234451 25348397 | colocalization,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy | ComPPI,IntAct |
| CASP8 | SMPD1 | 21157428 24234451 25348397 | colocalization,association | anti tag coimmunoprecipitation,fluorescence microscopy | ComPPI,IntAct |
| TNFRSF1A | SMPD1 | 21157428 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| NR1H2 | SMPD1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| BEX3 | SMPD1 | 11238738 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SMPD1 | ANXA7 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| SMPD1 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| SMPD1 | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| SMPD1 | OS9 | 25348397 | N/A | physical interaction | ComPPI |
| SMPD1 | ALDH3A2 | 25348397 | N/A | physical interaction | ComPPI |
| SMPD1 | ALG11 | 25348397 | N/A | physical interaction | ComPPI |
| SMPD1 | SLC27A2 | 25348397 | N/A | physical interaction | ComPPI |
| SMPD1 | CNTNAP3B | 25348397 | N/A | physical interaction | ComPPI |
| SMPD1 | INSL5 | 25348397 | N/A | physical interaction | ComPPI |
| SMPD1 | SEL1L | 25348397 | N/A | physical interaction | ComPPI |
| ASAH1 | SMPD1 | 12815059 14525934 | N/A | experimental interaction detection | HPRD |
| PRKCD | SMPD1 | 17303575 17698617 27898060 | stimulant | N/A | OmniPath |