Gene Information gene info

  1. Home

GENE：MYCN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MYCN
FullNmae MYCN proto-oncogene, bHLH transcription factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7559
EnsembleID ENSG00000134323
Uniprot P04198

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MYCN ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MYCN GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0006357,GO:0006357,GO:0010628,GO:0010629,GO:0019900,GO:0045893,GO:0045944,GO:0046983,GO:1902895,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MYCN hsa:4613 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F1 MYCN 12438307 14645238 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
E2F2 MYCN 12438307 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
E2F3 MYCN 12438307 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 MYCN 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MYCN 17072343 19151767 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 MYCN 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MYCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MYCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MYCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MYCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MYCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MYCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MYCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MYCN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ENO1 MYCN 15382088 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 MYCN 15382088 trascriptional regulation,stimulation inferred by curator TFlink
HOXA10 MYCN 21261500 trascriptional regulation,stimulation inferred by curator TFlink
HOXA9 MYCN 21261500 trascriptional regulation,stimulation inferred by curator TFlink
MXI1 MYCN 15382088 trascriptional regulation,stimulation inferred by curator TFlink
NCOR2 MYCN 21212796 trascriptional regulation,stimulation inferred by curator TFlink
PAX5 MYCN 9545244 trascriptional regulation,stimulation inferred by curator TFlink
PIAS2 MYCN 21123453 trascriptional regulation,stimulation inferred by curator TFlink
SP1 MYCN 14567977 21123453 22815527 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 MYCN 14567977 21123453 22815527 trascriptional regulation,stimulation inferred by curator TFlink
SP3 MYCN 14567977 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MYCN 24334727 trascriptional regulation,stimulation inferred by curator TFlink
WT1 MYCN 10470095 trascriptional regulation,stimulation inferred by curator TFlink
AR MYCN N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MYCN N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA MYCN N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000000B1C9 MYCN 21654684 rna interference,inhibition experimental interaction detection miRSponge
URS000006FDD4 MYCN 14697198 rna interference,inhibition experimental interaction detection miRSponge
URS00003D8730 MYCN 21654684 rna interference,inhibition experimental interaction detection miRSponge
URS0000076995 MYCN 21654684 rna interference,inhibition experimental interaction detection miRSponge
URS0000272A3D MYCN 21654684 rna interference,inhibition experimental interaction detection miRSponge
URS00000EED18 MYCN 17297439 18504438 18505919 19461653 22020437 22662276 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS000027352D MYCN 22020437 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00002C7B2B MYCN 22020437 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 MYCN 17297439 18504438 18505919 18927107 19461653 19890883 22020437 22662276 22743998 25348795 25416803 27764804 27836543 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS0000076995 MYCN 21654684 21835775 22012620 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000027352D MYCN 22020437 25416803 27764804 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00002C7B2B MYCN 22020437 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00003D8730 MYCN 21654684 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000272A3D MYCN 21654684 22012620 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS000006FDD4 MYCN 14697198 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000000B1C9 MYCN 21654684 23774216 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001D69F6 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001597DC MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000045147B MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001D6605 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000B0E50 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000140295 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004C5774 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000017DBB8 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000412AC7 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000759EB8 MYCN 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001F5B39 MYCN 25416803 26891231 27764804 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00003758F0 MYCN 25416803 27764804 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000ED600 MYCN 25416803 25864587 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 MYCN 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MTOR MYCN 22135298 phosphorylation N/A PhosphoSite
MYCN CSNK2A1 25361965 interaction type N/A PTMCode2
MYCN MAX 25361965 interaction type N/A PTMCode2
MAX MYCN 25361965 interaction type N/A PTMCode2
NMI MYCN 25361965 interaction type N/A PTMCode2
MYCN NMI 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NMI MYCN 10597290 14525934 24234451 25348397 8668343 physical association beta galactosidase complementation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
TRIM32 MYCN 25348397 N/A physical interaction ComPPI
EZH2 MYCN 24234451 25348397 27728805 association anti bait coimmunoprecipitation ComPPI,IntAct
SP1 MYCN 18003922 20697349 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXW7 MYCN 19111882 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AR MYCN 24234451 25348397 27728805 association anti bait coimmunoprecipitation ComPPI,IntAct
NONO MYCN 25348397 N/A physical interaction ComPPI
GSK3B MYCN 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDKN2A MYCN 25348397 N/A physical interaction ComPPI
UBC MYCN 25348397 N/A physical interaction ComPPI
PRMT1 MYCN 25348397 N/A physical interaction ComPPI
YBX1 MYCN 25348397 N/A physical interaction ComPPI
MYC MYCN 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CSNK2A1 MYCN 1425701 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRK5 MYCN 25348397 N/A physical interaction ComPPI
HUWE1 MYCN 25348397 N/A physical interaction ComPPI
CSNK2A2 MYCN 1425701 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HDAC2 MYCN 20697349 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MXD1 MYCN 11602341 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SKP2 MYCN 25348397 N/A physical interaction ComPPI
TRRAP MYCN 25348397 N/A physical interaction ComPPI
ZBTB17 MYCN 21123453 21908575 24234451 25348397 26766587 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
AURKA MYCN 19111882 23792191 24234451 25175806 25348397 27728805 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct,OmniPath
SIRT1 MYCN 21698133 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
LRPPRC MYCN 25348397 N/A physical interaction ComPPI
HDAC5 MYCN 25348397 N/A physical interaction ComPPI
NEDD4 MYCN 25348397 N/A physical interaction ComPPI
YAF2 MYCN 11593398 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,OmniPath
HDAC9 MYCN 25348397 N/A physical interaction ComPPI
RUNX3 MYCN 25348397 N/A physical interaction ComPPI
YEATS4 MYCN 25348397 N/A physical interaction ComPPI
MAX MYCN 10229200 10597290 14525934 18003922 23792191 24234451 25175806 25348397 27728805 association,physical association anti bait coimmunoprecipitation,beta galactosidase complementation,two hybrid,experimental interaction detection,physical interaction,in vitro,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
MYCN CDKN2A 17289033 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,imaging technique ComPPI,IntAct
MYCN FOXR1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MYCN EP400 25348397 N/A physical interaction ComPPI
MYCN GRSF1 25348397 N/A physical interaction ComPPI
MYCN KAT5 18003922 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MYCN HDAC1 18003922 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MYCN SUZ12 24234451 25348397 27728805 association anti bait coimmunoprecipitation ComPPI,IntAct
WDR5 MYCN 25348397 N/A physical interaction ComPPI
PMAIP1 MYCN 24234451 26859456 association chromatin immunoprecipitation assay IntAct
CDH5 MYCN 24234451 27728805 association chromatin immunoprecipitation assay IntAct
SRC MYCN 1425701 27898060 N/A N/A OmniPath
MYCN MCM7 17826980 27898060 stimulant N/A OmniPath
MYCN MCM2 17826980 27898060 stimulant N/A OmniPath
MYCN TP53 20145147 27898060 stimulant N/A OmniPath
MYCN MCM5 17826980 27898060 stimulant N/A OmniPath
CSNK2A1 MYCN 1425701 27898060 N/A N/A OmniPath
MYCN MCM4 17826980 27898060 stimulant N/A OmniPath
MYCN MCM6 17826980 27898060 stimulant N/A OmniPath
MTOR MYCN 19111882 25100564 27898060 N/A N/A OmniPath
MYCN MCM8 17826980 27898060 stimulant N/A OmniPath
MYCN MCM3 17826980 27898060 stimulant N/A OmniPath
CSNK2A2 MYCN 1425701 27898060 N/A N/A OmniPath

Visualization










  Return