Gene Information gene info

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GENE：IFNA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IFNA2
FullNmae interferon alpha 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5423
EnsembleID ENSG00000188379
Uniprot P01563

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IFNA2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IFNA2 autophagy 37690223 Consequently, these findings suggest that IFNA2 might play significant role in the regulation of autophagy in BCC development and progression and can be therapeutically targeted. retulator signature

Go Annotation:

GeneSymbol Go id
IFNA2 GO:0002250,GO:0002286,GO:0002323,GO:0005125,GO:0005125,GO:0005132,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006915,GO:0006954,GO:0006959,GO:0007166,GO:0007267,GO:0010629,GO:0019221,GO:0030183,GO:0032696,GO:0032714,GO:0033141,GO:0042100,GO:0043330,GO:0045581,GO:0045892,GO:0046597,GO:0051607,GO:0060337,GO:0060337,GO:0062023,GO:0097696,GO:0098586,GO:2000552

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IFNA2 hsa:3440 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa04217 Necroptosis - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05152 Tuberculosis - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05160 Hepatitis C - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05161 Hepatitis B - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05162 Measles - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05164 Influenza A - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
IFNA2 hsa:3440 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IFNAR2 IFNA2 10339405 17001036 18027911 21854986 23180781 physical association cross-linking study,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,solid phase assay InnateDB
IRF7 IFNA2 10938111 11473119 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
IFNA2 IRF3 11473119 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
CREBBP IFNA2 19349300 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 IFNA2 19349300 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF1 IFNA2 11473119 23180781 physical association affinity chromatography technology InnateDB
ELF4 IFNA2 23180781 24185615 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 IFNA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IFNA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IRF7 IFNA2 17236232 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
IFIT3 IFNA2 25348397 N/A physical interaction ComPPI
ISG15 IFNA2 25348397 N/A physical interaction ComPPI
IFNAR1 IFNA2 14525934 1834641 25348397 N/A experimental interaction detection,physical interaction,biochemical,genetic,in vivo ComPPI,HPRD
IFNA2 IFNAR2 10339405 11888273 14525934 21854986 24234451 25348397 N/A experimental interaction detection,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
IFNA2 IFNA5 25348397 N/A physical interaction ComPPI
IFNA2 ZER1 25348397 N/A physical interaction ComPPI
IFNA2 PGLYRP1 25348397 N/A physical interaction ComPPI
IFNA2 UBR3 25348397 N/A physical interaction ComPPI
IFNA4 IFNA2 25348397 N/A physical interaction ComPPI
PLEC IFNA2 24234451 30021884 physical association cross-linking study IntAct
IFNAR2 IFNA2 10339405 10395669 10984492 11888273 17001036 18027911 21854986 27898060 N/A N/A OmniPath

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