GENE：IFNA8
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | IFNA8 |
| FullNmae | interferon alpha 8 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5429 |
| EnsembleID | ENSG00000120242 |
| Uniprot | P32881 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| IFNA8 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IFNA8 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| IFNA8 | GO:0002250,GO:0002286,GO:0002323,GO:0005125,GO:0005126,GO:0005132,GO:0005515,GO:0005576,GO:0005615,GO:0006959,GO:0019221,GO:0030183,GO:0033141,GO:0042100,GO:0043330,GO:0051607,GO:0060337,GO:0098586 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| IFNA8 | hsa:3445 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05160 | Hepatitis C - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05162 | Measles - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05164 | Influenza A - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05168 | Herpes simplex virus 1 infection - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
| IFNA8 | hsa:3445 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CTCF | IFNA8 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IFIT3 | IFNA8 | 25348397 | N/A | physical interaction | ComPPI |
| ISG15 | IFNA8 | 25348397 | N/A | physical interaction | ComPPI |
| IFNAR1 | IFNA8 | 25348397 | N/A | physical interaction,biochemical | ComPPI |
| APOE | IFNA8 | 25348397 | N/A | physical interaction | ComPPI |
| ADAMTS1 | IFNA8 | 25348397 | N/A | physical interaction | ComPPI |
| IFIT1 | IFNA8 | 25348397 | N/A | physical interaction | ComPPI |
| IFNA1 | IFNA8 | 25348397 | N/A | physical interaction | ComPPI |
| IFNA8 | APP | 25348397 | N/A | physical interaction | ComPPI |
| IFNA8 | OMA1 | 25348397 | N/A | physical interaction | ComPPI |
| IFNA8 | IFNAR2 | 14525934 25348397 8969169 | N/A | experimental interaction detection,physical interaction,biochemical | ComPPI,HPRD |
| IFNA4 | IFNA8 | 25348397 | N/A | physical interaction | ComPPI |
| IFNA8 | IFNAR1 | 21856167 27898060 7592797 | N/A | N/A | OmniPath |