Gene Information gene info

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GENE：SNX5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SNX5
FullNmae sorting nexin 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14969
EnsembleID ENSG00000089006
Uniprot Q9Y5X3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SNX5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SNX5 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SNX5 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SNX5 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SNX5 GO:0001726,GO:0001891,GO:0005515,GO:0005768,GO:0005829,GO:0005903,GO:0006886,GO:0006907,GO:0006907,GO:0007174,GO:0009898,GO:0010314,GO:0016241,GO:0030904,GO:0030905,GO:0031748,GO:0034452,GO:0034452,GO:0035091,GO:0035091,GO:0035091,GO:0042147,GO:0042147,GO:0042147,GO:0043231,GO:0045296,GO:0045776,GO:0045893,GO:0046628,GO:0048471,GO:0070273,GO:0070685,GO:0080025,GO:0097422,GO:0098559

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SNX5 hsa:27131 path:hsa04144 Endocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SNX5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SNX5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SNX5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SNX5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC SNX5 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
TFAP2C SNX5 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 SNX5 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 SNX5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF SNX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SNX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SNX5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 SNX5 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000013DD8 SNX5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000028BB8 SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A SNX5 20371350 22012620 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA SNX5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 SNX5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 SNX5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA SNX5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004CD810 SNX5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 SNX5 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A SNX5 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SNX5 FANCA 25361965 interaction type N/A PTMCode2
FANCA SNX5 25361965 interaction type N/A PTMCode2
CLTC SNX5 25361965 interaction type N/A PTMCode2
SNX5 CLTC 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FAM90A1 SNX5 25348397 N/A physical interaction ComPPI
APPBP2 SNX5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZYX SNX5 11423549 24234451 25348397 physical association two hybrid ComPPI,IntAct
NUP155 SNX5 25348397 N/A physical interaction ComPPI
HCLS1 SNX5 25348397 N/A physical interaction ComPPI
HGS SNX5 25348397 N/A physical interaction ComPPI
CDH1 SNX5 25348397 N/A physical interaction ComPPI
SNX1 SNX5 23085988 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SNX2 SNX5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XPO5 SNX5 25348397 N/A physical interaction ComPPI
PRKRA SNX5 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CLTC SNX5 25348397 N/A physical interaction ComPPI
ITSN1 SNX5 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
VAPB SNX5 25348397 N/A physical interaction ComPPI
GTF2E2 SNX5 25348397 N/A physical interaction ComPPI
STK4 SNX5 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CDC37 SNX5 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIP5K1C SNX5 25348397 N/A physical interaction ComPPI
DNAJB11 SNX5 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRIM25 SNX5 25348397 N/A physical interaction ComPPI
ARFIP2 SNX5 25348397 N/A physical interaction ComPPI
MIB1 SNX5 14525934 16857196 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CLTCL1 SNX5 15133132 25348397 27898060 N/A two hybrid,physical interaction,in vivo ComPPI,OmniPath
SNX5 FANCA 10600472 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
SNX5 HMOX2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNX5 MESD 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNX5 PFDN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNX5 VPS33B 25348397 N/A physical interaction ComPPI
SNX5 BOP1 25348397 N/A physical interaction ComPPI
SNX5 ELAC2 25348397 N/A physical interaction ComPPI
SNX5 SARS1 25348397 N/A physical interaction ComPPI
SNX5 LAPTM4B 25348397 N/A physical interaction ComPPI
SNX5 BIN3 25348397 N/A physical interaction ComPPI
SNX5 GAS2L1 25348397 N/A physical interaction ComPPI
SNX5 FAM221A 25348397 N/A physical interaction ComPPI
SNX5 C11ORF42 25348397 N/A physical interaction ComPPI
SNX5 DNM3 25348397 N/A physical interaction ComPPI
SNX5 GNAT2 25348397 N/A physical interaction ComPPI
SNX5 SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SNX5 C1ORF87 25348397 N/A physical interaction ComPPI
SNX5 CCDC102B 25348397 N/A physical interaction ComPPI
SNX5 TEX28 25348397 N/A physical interaction ComPPI
SNX5 KLHL10 25348397 N/A physical interaction ComPPI
SNX5 MLX 25348397 N/A physical interaction ComPPI
SNX5 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
SNX5 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SNX5 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SNX5 CAT 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BLVRA SNX5 25348397 N/A physical interaction ComPPI
AQP2 SNX5 25348397 N/A physical interaction ComPPI
SNX5 SNX5 23085988 24234451 physical association pull down IntAct

Source Target Pmid Interactiontype Methods Database
URS00008B8E77 SNX5 27087310 direct interaction,inhibition N/A NPInter

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